ATE224952T1 - Untereinheiten von menschlichen n-methyl-d- aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung - Google Patents

Untereinheiten von menschlichen n-methyl-d- aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung

Info

Publication number
ATE224952T1
ATE224952T1 AT94916547T AT94916547T ATE224952T1 AT E224952 T1 ATE224952 T1 AT E224952T1 AT 94916547 T AT94916547 T AT 94916547T AT 94916547 T AT94916547 T AT 94916547T AT E224952 T1 ATE224952 T1 AT E224952T1
Authority
AT
Austria
Prior art keywords
subunits
nucleic acids
human
receptors
receptor
Prior art date
Application number
AT94916547T
Other languages
English (en)
Inventor
Lorrie P Daggett
Steven B Ellis
Chen Wang Liaw
Chin-Chun Lu
Original Assignee
Merck & Co Inc
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21977682&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE224952(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE224952T1 publication Critical patent/ATE224952T1/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Control Of El Displays (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT94916547T 1993-04-20 1994-04-20 Untereinheiten von menschlichen n-methyl-d- aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung ATE224952T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5244993A 1993-04-20 1993-04-20
PCT/US1994/004387 WO1994024284A1 (en) 1993-04-20 1994-04-20 Human n-methyl-d-aspartate receptor subunits, nucleic acids encoding same and uses therefor

Publications (1)

Publication Number Publication Date
ATE224952T1 true ATE224952T1 (de) 2002-10-15

Family

ID=21977682

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94916547T ATE224952T1 (de) 1993-04-20 1994-04-20 Untereinheiten von menschlichen n-methyl-d- aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung

Country Status (10)

Country Link
US (11) US5849895A (de)
EP (1) EP0696320B1 (de)
JP (1) JPH08509607A (de)
AT (1) ATE224952T1 (de)
AU (1) AU696922B2 (de)
CA (1) CA2159106C (de)
DE (1) DE69431432T2 (de)
ES (1) ES2182843T3 (de)
GB (1) GB2286188B (de)
WO (1) WO1994024284A1 (de)

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CA2110934A1 (en) 1992-12-11 1994-06-12 Robert L. Foldes Human cns receptors of the nmda-r1 family
ATE224952T1 (de) 1993-04-20 2002-10-15 Merck & Co Inc Untereinheiten von menschlichen n-methyl-d- aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung
EP0674003A3 (de) * 1994-03-25 1997-09-10 Allelix Biopharma Proteine die menschliche CNS Rezeptoren modulieren.
GB9414997D0 (en) * 1994-07-26 1994-09-14 Merck Sharp & Dohme Receptor cloning
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
US6822084B1 (en) * 1999-06-25 2004-11-23 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
DE60041773D1 (de) * 1999-08-31 2009-04-23 Univ Boston Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten
US20040204490A1 (en) * 1999-08-31 2004-10-14 Farb David H. Effect of steroids on NMDA receptors depends on subunit composition
GB9929582D0 (en) * 1999-12-16 2000-02-09 Univ Bristol Chemical compounds
US6916816B2 (en) * 1999-12-16 2005-07-12 The Board Of Regents Of The University Of Nebraska Phenanthryl piperazinyl dicarboxylic acids as selective NMDA receptor modulating agents
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US20030092071A1 (en) * 2000-02-01 2003-05-15 Jasna Jerecic Interaction of NMDA receptor with protein tyrosine phosphatase
WO2002064772A1 (fr) * 2001-01-30 2002-08-22 Shionogi & Co., Ltd. Variant d'epissure du recepteur nmda humain
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CA2615147A1 (en) * 2005-07-14 2007-01-18 The University Of British Columbia Neuroprotective modulation of nmda receptor subtype activities
EP1902733A1 (de) * 2006-09-19 2008-03-26 Laboratorios Del Dr. Esteve, S.A. Kombination von einem NMDA Rezeptorligand und einer Verbindung mit 5-HT6 Rezeptor-Affinität
US20100210816A1 (en) * 2006-12-12 2010-08-19 Svetlana Dambinova NMDAR Biomarkers for Diagnosing and Treating Cerebral Ischemia
EP2175886A1 (de) * 2007-06-28 2010-04-21 CNSBio Pty Ltd Kombinationsverfahren und zusammensetzungen zur behandlung von neuropathischen schmerzen
EP2254420A4 (de) 2008-02-20 2012-02-15 Targia Pharmaceuticals Zns-pharmazeutika und verfahren für ihre verwendung
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WO2017109709A2 (en) * 2015-12-22 2017-06-29 Novartis Ag A high-throughput assay method for identifying allosteric nmda receptor modulators
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CA2110934A1 (en) * 1992-12-11 1994-06-12 Robert L. Foldes Human cns receptors of the nmda-r1 family
ATE224952T1 (de) 1993-04-20 2002-10-15 Merck & Co Inc Untereinheiten von menschlichen n-methyl-d- aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung
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GB9414997D0 (en) * 1994-07-26 1994-09-14 Merck Sharp & Dohme Receptor cloning

Also Published As

Publication number Publication date
US6825322B2 (en) 2004-11-30
US6376660B1 (en) 2002-04-23
US6316611B1 (en) 2001-11-13
US5985586A (en) 1999-11-16
DE69431432D1 (de) 2002-10-31
US6111091A (en) 2000-08-29
WO1994024284A1 (en) 1994-10-27
ES2182843T3 (es) 2003-03-16
AU696922B2 (en) 1998-09-24
CA2159106C (en) 2009-10-06
US6521413B1 (en) 2003-02-18
US6033865A (en) 2000-03-07
US20020161193A1 (en) 2002-10-31
US20020161215A1 (en) 2002-10-31
CA2159106A1 (en) 1994-10-27
US6864358B2 (en) 2005-03-08
EP0696320A1 (de) 1996-02-14
US6956102B2 (en) 2005-10-18
JPH08509607A (ja) 1996-10-15
US6469142B1 (en) 2002-10-22
AU6817594A (en) 1994-11-08
GB2286188B (en) 1997-11-12
DE69431432T2 (de) 2003-04-24
GB9503689D0 (en) 1995-04-12
US20030013866A1 (en) 2003-01-16
GB2286188A (en) 1995-08-09
EP0696320B1 (de) 2002-09-25
US5849895A (en) 1998-12-15

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