ATE224705T1 - Zusammensetzungen mit kationischen amphiphilen und colipiden zur intrazellulären verabreichung therapeutischer moleküle - Google Patents
Zusammensetzungen mit kationischen amphiphilen und colipiden zur intrazellulären verabreichung therapeutischer moleküleInfo
- Publication number
- ATE224705T1 ATE224705T1 AT97929716T AT97929716T ATE224705T1 AT E224705 T1 ATE224705 T1 AT E224705T1 AT 97929716 T AT97929716 T AT 97929716T AT 97929716 T AT97929716 T AT 97929716T AT E224705 T1 ATE224705 T1 AT E224705T1
- Authority
- AT
- Austria
- Prior art keywords
- colipides
- amphiphils
- compositions containing
- therapeutic molecules
- containing cationic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4712—Cystic fibrosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/657,238 US5935936A (en) | 1996-06-03 | 1996-06-03 | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
PCT/US1997/009142 WO1997046223A1 (en) | 1996-06-03 | 1997-05-30 | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE224705T1 true ATE224705T1 (de) | 2002-10-15 |
Family
ID=24636394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97929716T ATE224705T1 (de) | 1996-06-03 | 1997-05-30 | Zusammensetzungen mit kationischen amphiphilen und colipiden zur intrazellulären verabreichung therapeutischer moleküle |
Country Status (8)
Country | Link |
---|---|
US (1) | US5935936A (de) |
EP (1) | EP0845981B1 (de) |
JP (1) | JPH11511757A (de) |
AT (1) | ATE224705T1 (de) |
CA (1) | CA2228444A1 (de) |
DE (1) | DE69715786T2 (de) |
ES (1) | ES2187791T3 (de) |
WO (1) | WO1997046223A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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US5674908A (en) | 1993-12-20 | 1997-10-07 | Life Technologies, Inc. | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
US6989434B1 (en) * | 1994-02-11 | 2006-01-24 | Invitrogen Corporation | Reagents for intracellular delivery of macromolecules |
US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
AU6949098A (en) * | 1997-04-04 | 1998-10-30 | Valentis, Inc. | Improved methods of delivery using cationic lipids and helper lipids |
US6235310B1 (en) | 1997-04-04 | 2001-05-22 | Valentis, Inc. | Methods of delivery using cationic lipids and helper lipids |
EP1027033B1 (de) * | 1997-05-14 | 2009-07-22 | The University Of British Columbia | Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln |
US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
EP1129064B1 (de) | 1998-11-12 | 2008-01-09 | Invitrogen Corporation | Transportreagentien |
US6521431B1 (en) | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
IL131074A0 (en) | 1999-07-23 | 2001-03-19 | Polygene Ltd | A biodegradable polycation composition for delivery of an anionic macromolecule |
DE60038220T2 (de) * | 1999-08-27 | 2009-03-12 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Chimerische antisense-oligonukleotide und zelltransfektions-zusammensetzungen davon |
US6677445B1 (en) * | 1999-08-27 | 2004-01-13 | Chiron Corporation | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
EP2336169A1 (de) * | 2000-04-21 | 2011-06-22 | New England Medical Center Hospital | G-Protein gekoppelte Rezeptor (GPCR)-Agonisten und -Antagonisten sowie Verfahren zur GPCR-Aktivierung/ -Inhibierung. |
US7696168B2 (en) * | 2000-04-21 | 2010-04-13 | Tufts Medical Center, Inc. | G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
WO2001097829A2 (en) * | 2000-06-19 | 2001-12-27 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
JP2005502309A (ja) * | 2000-12-23 | 2005-01-27 | カイロン コーポレイション | オリゴヌクレオチドトランスフェクションスクリーニング方法 |
IL140844A0 (en) * | 2001-01-10 | 2002-02-10 | Polygene Ltd | Cationic polysaccharide compositions |
US20030096414A1 (en) | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
WO2002100317A2 (en) * | 2001-05-25 | 2002-12-19 | The Trustees Of The University Of Pennsylvania | Targeted particles and methods of using the same |
WO2003035669A1 (en) * | 2001-10-22 | 2003-05-01 | Sterrenbeld Biotechnologie North America, Inc. | Amphiphilic cationic lipids derived from cholesterol |
AU2002247919A1 (en) * | 2002-03-26 | 2003-10-08 | Council Of Scientific And Industrial Research | Cationic amphiphiles for intracellular delivery of therapeutic molecules its composition, process and use thereof |
US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
WO2003093449A2 (en) * | 2002-05-06 | 2003-11-13 | Nucleonics, Inc. | Methods for delivery of nucleic acids |
US7183263B2 (en) | 2002-07-17 | 2007-02-27 | University Of Utah Research Foundation | Linear polyethylenimine-sterol conjugates for gene delivery |
AU2003274906A1 (en) * | 2002-07-31 | 2004-02-16 | Nucleonics, Inc. | Double stranded rna structures and constructs, and methods for generating and using the same |
EP1578193A4 (de) * | 2002-12-23 | 2011-06-15 | Vical Inc | Gefriertrocknungsverfahren für nukleinsäure-/blockcopolymer-/kationtensid-komplexe |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
JP4944032B2 (ja) | 2004-09-13 | 2012-05-30 | ジェンザイム・コーポレーション | 多量体構築物 |
BRPI0517058A (pt) * | 2004-11-04 | 2008-09-30 | New England Medical Center Inc | agonistas e antagonistas do receptor acoplado à proteìna g e métodos de uso |
DK2494993T3 (en) | 2007-05-04 | 2018-11-12 | Marina Biotech Inc | Amino acid lipids and uses thereof |
SI2889043T1 (sl) | 2008-12-16 | 2019-08-30 | Genzyme Corporation | Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein |
NZ700688A (en) | 2009-12-01 | 2016-02-26 | Shire Human Genetic Therapies | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
JP6184945B2 (ja) | 2011-06-08 | 2017-08-23 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | mRNA送達のための脂質ナノ粒子組成物および方法 |
EP3536787A1 (de) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nukleaseresistente polynukleotide und verwendungen davon |
EA037922B1 (ru) | 2013-03-14 | 2021-06-07 | Шир Хьюман Дженетик Терапис, Инк. | мРНК CFTR И КОМПОЗИЦИИ ДЛЯ ЛЕЧЕНИЯ МУКОВИСЦИДОЗА У МЛЕКОПИТАЮЩЕГО |
EP2970955B1 (de) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Verfahren zur reinigung von messenger-rna |
ES2954366T3 (es) | 2013-10-22 | 2023-11-21 | Translate Bio Inc | Terapia de ácido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa |
CA2928186A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
JPWO2015093588A1 (ja) * | 2013-12-21 | 2017-03-23 | Ktnバイオテック株式会社 | 抗癌剤 |
ES2750661T3 (es) | 2014-04-25 | 2020-03-26 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
WO2016011203A1 (en) | 2014-07-15 | 2016-01-21 | Life Technologies Corporation | Compositions with lipid aggregates and methods for efficient delivery of molecules to cells |
MX2019010155A (es) | 2017-02-27 | 2020-12-10 | Translate Bio Inc | Arnm de cftr optimizado por codón novedoso. |
IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis through the administration of mRNA with an optimal codon encoding ctfr |
CN112930396B (zh) | 2018-08-24 | 2024-05-24 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
Family Cites Families (30)
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US4394448A (en) * | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
JPS617292A (ja) * | 1984-06-20 | 1986-01-13 | Japan Atom Energy Res Inst | 制癌剤を結合させたエストラサイト系化合物を製造する方法 |
US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4971803A (en) * | 1985-04-08 | 1990-11-20 | California Institute Of Technology | Lamellar vesicles formed of cholesterol derivatives |
JPH02500360A (ja) * | 1986-07-28 | 1990-02-08 | リポソーム テクノロジー,インコーポレイテッド | 粘膜組織上での高い保持力を有するリポソーム |
US5043164A (en) * | 1989-01-17 | 1991-08-27 | The University Of Tennessee Research Corporation | Blood-stable, cholesterol-free liposomes |
FR2645866B1 (fr) * | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
US5004737A (en) * | 1989-09-22 | 1991-04-02 | Pacific Chemical Co., Ltd. | Quaternary ammonium-substituted sterol derivatives |
CA2037478A1 (en) * | 1990-03-05 | 1991-09-06 | Richard Gregory | Diagnostic and treatment methods involving the cystic fibrosis transmembrane regulator |
US5279833A (en) * | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
EP0490379A3 (de) * | 1990-12-13 | 1992-06-24 | BERLIN-CHEMIE Aktiengesellschaft | Diaminosäurederivate und pharmazeutische Zusammensetzungen |
US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
US5334761A (en) * | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
US5705655A (en) * | 1992-12-17 | 1998-01-06 | Megabios Corporation | Amphiphilic nitrogen containing imidazolinium derivative compounds and uses |
DE69412596T2 (de) * | 1993-03-10 | 1999-03-04 | Magainin Pharma | Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel |
US5578475A (en) * | 1993-07-12 | 1996-11-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
NZ276975A (en) * | 1993-11-24 | 1998-04-27 | Megabios Corp | Guanidine based amphiphiles and their use in liposomes for delivering genetic material intracellularly |
CA2176714A1 (en) * | 1993-11-24 | 1995-06-01 | Timothy D. Heath | Amphiphilic derivatives of piperazine |
JPH09508099A (ja) * | 1993-12-20 | 1997-08-19 | ユニヴェルシテ リブル ドゥ ブリュッセル | 細胞中に少なくとも一つの分子を導入できる化合物 |
AU1919295A (en) * | 1994-02-14 | 1995-08-29 | Indiana University Foundation | Aminophospholipid compositions and uses thereof |
WO1995024222A1 (en) * | 1994-03-07 | 1995-09-14 | University Of Medicine & Dentistry Of New Jersey | Cyclic polycationic polymer-oligonucleotide conjugates and methods for preparing same |
US5670347A (en) * | 1994-05-11 | 1997-09-23 | Amba Biosciences Llc | Peptide-mediated gene transfer |
US5908635A (en) * | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
WO1996020208A2 (de) * | 1994-12-28 | 1996-07-04 | Max-Delbrück-Centrum für Molekulare Medizin | Neues cholesterolderivat für den liposomalen gentransfer |
FR2744453B1 (fr) * | 1996-02-05 | 1998-07-10 | Transgene Sa | Composes lipopolyamines, compositions pharmaceutiques en comprenant, vecteurs de transfert d'acide nucleique et procede de preparation |
-
1996
- 1996-06-03 US US08/657,238 patent/US5935936A/en not_active Expired - Fee Related
-
1997
- 1997-05-30 EP EP97929716A patent/EP0845981B1/de not_active Expired - Lifetime
- 1997-05-30 ES ES97929716T patent/ES2187791T3/es not_active Expired - Lifetime
- 1997-05-30 DE DE69715786T patent/DE69715786T2/de not_active Expired - Fee Related
- 1997-05-30 CA CA002228444A patent/CA2228444A1/en not_active Abandoned
- 1997-05-30 WO PCT/US1997/009142 patent/WO1997046223A1/en active IP Right Grant
- 1997-05-30 AT AT97929716T patent/ATE224705T1/de not_active IP Right Cessation
- 1997-05-30 JP JP10500678A patent/JPH11511757A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH11511757A (ja) | 1999-10-12 |
EP0845981A1 (de) | 1998-06-10 |
EP0845981B1 (de) | 2002-09-25 |
US5935936A (en) | 1999-08-10 |
DE69715786T2 (de) | 2003-05-28 |
DE69715786D1 (de) | 2002-10-31 |
WO1997046223A1 (en) | 1997-12-11 |
CA2228444A1 (en) | 1997-12-11 |
ES2187791T3 (es) | 2003-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |