ATE221524T1 - Thioxanthenone als antitumor mittel - Google Patents
Thioxanthenone als antitumor mittelInfo
- Publication number
- ATE221524T1 ATE221524T1 AT98113469T AT98113469T ATE221524T1 AT E221524 T1 ATE221524 T1 AT E221524T1 AT 98113469 T AT98113469 T AT 98113469T AT 98113469 T AT98113469 T AT 98113469T AT E221524 T1 ATE221524 T1 AT E221524T1
- Authority
- AT
- Austria
- Prior art keywords
- ch2n
- alkyl
- hydrogen
- hydroxy
- group
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 title 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- -1 methoxy, hydroxy Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
- C07F9/655372—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D335/16—Oxygen atoms, e.g. thioxanthones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/044,843 US5346917A (en) | 1991-06-10 | 1993-04-08 | Thioxanthenone antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE221524T1 true ATE221524T1 (de) | 2002-08-15 |
Family
ID=21934632
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94200892T ATE181068T1 (de) | 1993-04-08 | 1994-03-31 | Thioxanthenone als antitumormittel |
| AT02000949T ATE286043T1 (de) | 1993-04-08 | 1994-03-31 | Thioxanthenon antitumormittel |
| AT98113469T ATE221524T1 (de) | 1993-04-08 | 1994-03-31 | Thioxanthenone als antitumor mittel |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94200892T ATE181068T1 (de) | 1993-04-08 | 1994-03-31 | Thioxanthenone als antitumormittel |
| AT02000949T ATE286043T1 (de) | 1993-04-08 | 1994-03-31 | Thioxanthenon antitumormittel |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5346917A (de) |
| EP (3) | EP0619315B1 (de) |
| JP (1) | JPH06340655A (de) |
| KR (1) | KR100344136B1 (de) |
| AT (3) | ATE181068T1 (de) |
| AU (1) | AU679717B2 (de) |
| CA (1) | CA2120782C (de) |
| CZ (1) | CZ289473B6 (de) |
| DE (3) | DE69431131T2 (de) |
| DK (3) | DK1197491T3 (de) |
| ES (3) | ES2234935T3 (de) |
| FI (2) | FI941638A (de) |
| GR (1) | GR3030949T3 (de) |
| HU (1) | HUT67899A (de) |
| IL (1) | IL109241A (de) |
| MY (1) | MY131770A (de) |
| NO (1) | NO306947B1 (de) |
| NZ (1) | NZ260255A (de) |
| PT (2) | PT882723E (de) |
| RU (1) | RU2138495C1 (de) |
| SG (1) | SG52765A1 (de) |
| SK (1) | SK283799B6 (de) |
| TW (1) | TW242623B (de) |
| UA (1) | UA41281C2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665760A (en) * | 1995-09-18 | 1997-09-09 | Sanofi Winthrop, Inc. | Lyophilized thioxanthenone antitumor agents |
| US7126011B2 (en) * | 2000-11-15 | 2006-10-24 | Prom Limited | Process for the preparation of thioxanthones |
| GB0115893D0 (en) * | 2001-06-28 | 2001-08-22 | Sanofi Synthelabo | Formulations |
| US6747039B2 (en) * | 2002-03-12 | 2004-06-08 | Albany Molecular Research, Inc. | Aza-benzothiopyranoindazoles with antitumor activity |
| US20030212061A1 (en) * | 2002-03-12 | 2003-11-13 | Haydar Simon N. | Aza-thioxanthenones with antitumor activity |
| TW200510367A (en) * | 2002-11-18 | 2005-03-16 | Arqule Inc | Novel lapachone compounds, their preparation, and the use thereof |
| US6767919B2 (en) * | 2002-12-17 | 2004-07-27 | Walker Cancer Research Institute, Inc. | High specificity anticancer agents |
| US20080114055A1 (en) * | 2006-11-10 | 2008-05-15 | Zoltan Laboratories Llc | Thioxanthone Compounds to Reverse Weight Loss |
| US20080207738A1 (en) * | 2007-02-28 | 2008-08-28 | Cancure Laboratories, Llc | Drug combinations to treat drug resistant tumors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3312598A (en) * | 1965-06-14 | 1967-04-04 | Sterling Drug Inc | Fermentative oxidation of substituted thioxanthenes and xanthenes |
| US3745172A (en) * | 1970-10-05 | 1973-07-10 | Sterling Drug Inc | 1-(di-(lower-alkyl)aminoalkylamino)-9-oxothioxanthenes |
| US4539412A (en) * | 1982-07-08 | 1985-09-03 | Rensselaer Polytechnic Institute | 7-Hydroxylucanthone, 7-hydroxhycanthone and their analogs |
| GB8400203D0 (en) * | 1984-01-05 | 1984-02-08 | Wellcome Found | Tricyclic compounds |
| US4582851A (en) * | 1984-02-06 | 1986-04-15 | Warner-Lambert Company | Anti-bacterial 1,4-aminoalkylamino-9H-thioxanthen-9-one derivatives, compositions, and method of use therefor |
| US5091410A (en) * | 1991-06-10 | 1992-02-25 | Sterling Winthrop Inc. | Thioxanthenone antitumor agents |
| AU642596B2 (en) * | 1991-06-10 | 1993-10-21 | Sanofi-Synthelabo | Thioxanthenone antitumor agents |
-
1993
- 1993-04-08 US US08/044,843 patent/US5346917A/en not_active Expired - Lifetime
-
1994
- 1994-03-15 TW TW083102225A patent/TW242623B/zh active
- 1994-03-23 US US08/216,989 patent/US5380749A/en not_active Expired - Lifetime
- 1994-03-30 CZ CZ1994748A patent/CZ289473B6/cs unknown
- 1994-03-31 ES ES02000949T patent/ES2234935T3/es not_active Expired - Lifetime
- 1994-03-31 DE DE69431131T patent/DE69431131T2/de not_active Expired - Fee Related
- 1994-03-31 AT AT94200892T patent/ATE181068T1/de not_active IP Right Cessation
- 1994-03-31 DK DK02000949T patent/DK1197491T3/da active
- 1994-03-31 DE DE69418929T patent/DE69418929T2/de not_active Expired - Fee Related
- 1994-03-31 EP EP94200892A patent/EP0619315B1/de not_active Expired - Lifetime
- 1994-03-31 ES ES94200892T patent/ES2134314T3/es not_active Expired - Lifetime
- 1994-03-31 DK DK98113469T patent/DK0882723T3/da active
- 1994-03-31 DE DE69434216T patent/DE69434216T2/de not_active Expired - Fee Related
- 1994-03-31 PT PT98113469T patent/PT882723E/pt unknown
- 1994-03-31 AT AT02000949T patent/ATE286043T1/de not_active IP Right Cessation
- 1994-03-31 EP EP98113469A patent/EP0882723B1/de not_active Expired - Lifetime
- 1994-03-31 PT PT02000949T patent/PT1197491E/pt unknown
- 1994-03-31 ES ES98113469T patent/ES2180100T3/es not_active Expired - Lifetime
- 1994-03-31 AT AT98113469T patent/ATE221524T1/de not_active IP Right Cessation
- 1994-03-31 EP EP02000949A patent/EP1197491B1/de not_active Expired - Lifetime
- 1994-03-31 DK DK94200892T patent/DK0619315T3/da active
- 1994-04-05 SK SK390-94A patent/SK283799B6/sk unknown
- 1994-04-07 MY MYPI94000837A patent/MY131770A/en unknown
- 1994-04-07 AU AU59301/94A patent/AU679717B2/en not_active Ceased
- 1994-04-07 NZ NZ260255A patent/NZ260255A/en unknown
- 1994-04-07 KR KR1019940007216A patent/KR100344136B1/ko not_active IP Right Cessation
- 1994-04-07 IL IL10924194A patent/IL109241A/en unknown
- 1994-04-07 CA CA002120782A patent/CA2120782C/en not_active Expired - Fee Related
- 1994-04-07 HU HU9400992A patent/HUT67899A/hu unknown
- 1994-04-07 RU RU94011565A patent/RU2138495C1/ru not_active IP Right Cessation
- 1994-04-08 UA UA94005173A patent/UA41281C2/uk unknown
- 1994-04-08 NO NO941288A patent/NO306947B1/no unknown
- 1994-04-08 FI FI941638A patent/FI941638A/fi not_active IP Right Cessation
- 1994-04-08 JP JP6070540A patent/JPH06340655A/ja active Pending
-
1995
- 1995-03-31 SG SG1996009160A patent/SG52765A1/en unknown
-
1999
- 1999-08-10 GR GR990402030T patent/GR3030949T3/el unknown
-
2004
- 2004-12-30 FI FI20041691A patent/FI20041691A/fi not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE221524T1 (de) | Thioxanthenone als antitumor mittel | |
| NO922273D0 (no) | Tioxantenon-antitumormidler | |
| FI940011A (fi) | Mono- ja bis-alkyyliaminoantrasykliinit | |
| BR9405997A (pt) | Composições antitumorais e métodos de tratamento |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |