ATE219367T1 - Verfahren zur senkung des augeninnendrucks im auge von säugern unter anwendung von muskarinantagonisten - Google Patents

Verfahren zur senkung des augeninnendrucks im auge von säugern unter anwendung von muskarinantagonisten

Info

Publication number
ATE219367T1
ATE219367T1 AT93907541T AT93907541T ATE219367T1 AT E219367 T1 ATE219367 T1 AT E219367T1 AT 93907541 T AT93907541 T AT 93907541T AT 93907541 T AT93907541 T AT 93907541T AT E219367 T1 ATE219367 T1 AT E219367T1
Authority
AT
Austria
Prior art keywords
alpha
methyl
piperidinyl
dihydro
benzodiazepin
Prior art date
Application number
AT93907541T
Other languages
English (en)
Inventor
Mussie Elizabeth Wolde
Guadalupe Ruiz
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE219367T1 publication Critical patent/ATE219367T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT93907541T 1992-03-18 1993-03-16 Verfahren zur senkung des augeninnendrucks im auge von säugern unter anwendung von muskarinantagonisten ATE219367T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/853,374 US5716952A (en) 1992-03-18 1992-03-18 Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
PCT/US1993/002403 WO1993018772A1 (en) 1992-03-18 1993-03-16 Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists

Publications (1)

Publication Number Publication Date
ATE219367T1 true ATE219367T1 (de) 2002-07-15

Family

ID=25315868

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93907541T ATE219367T1 (de) 1992-03-18 1993-03-16 Verfahren zur senkung des augeninnendrucks im auge von säugern unter anwendung von muskarinantagonisten

Country Status (8)

Country Link
US (1) US5716952A (de)
EP (1) EP0634932B1 (de)
JP (1) JPH07504915A (de)
AT (1) ATE219367T1 (de)
AU (1) AU666536B2 (de)
DE (1) DE69332048T2 (de)
ES (1) ES2177543T3 (de)
WO (1) WO1993018772A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000229961A (ja) 1998-12-11 2000-08-22 Sagami Chem Res Center ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6164282A (en) * 1999-01-27 2000-12-26 Allergan Sales, Inc. Methods for restoring and/or enhancing accommodation in pseudo phakia
AU2002335031C1 (en) * 2001-10-18 2006-11-16 Schering Corporation Himbacine analogues as thrombin receptor antagonists
CA2573674A1 (en) 2004-07-16 2006-01-26 Proteosys Ag Muscarinic antagonists with parp and sir modulating activity as agents for inflammatory diseases
WO2010081823A1 (en) 2009-01-13 2010-07-22 Proteosys Ag Pirenzepine as otoprotective agent
SG192648A1 (en) * 2011-02-09 2013-09-30 Singapore Health Serv Pte Ltd Transglutaminase-2 inhibitors and uses thereof
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US11382909B2 (en) * 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
US11052094B2 (en) 2015-05-29 2021-07-06 Sydnexis, Inc. D2O stabilized pharmaceutical formulations
KR102281667B1 (ko) 2017-05-11 2021-07-23 네바카 아이엔씨. 아트로핀 약학 조성물 (atropine pharmaceutical compositions)
AU2018371787A1 (en) * 2017-11-21 2020-11-05 Sydnexis, Inc. Ophthalmic composition and delivery device thereof
CA3189821A1 (en) 2020-08-04 2022-02-10 Santen Pharmaceutical Co., Ltd. Agent for treating myopia, preventing myopia and/or suppressing myopia progression
JP7062846B1 (ja) * 2020-10-14 2022-05-06 参天製薬株式会社 安定な医薬組成物
TW202402753A (zh) * 2022-03-30 2024-01-16 日商參天製藥股份有限公司 高純度化合物之製造方法及純化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918407A (en) * 1957-04-08 1959-12-22 Lakeside Lab Inc Anti-spasmodics specific for upper gastrointestinal pain and spasm
US3467756A (en) * 1967-03-16 1969-09-16 Merck & Co Inc Composition and method for treating glaucoma
DE1795183B1 (de) * 1968-08-20 1972-07-20 Thomae Gmbh Dr K 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
US4197301A (en) * 1978-10-16 1980-04-08 Allergan Pharmaceuticals, Inc. Topical ophthalmic use of Prazosin
US4565821A (en) * 1983-03-21 1986-01-21 The Texas A&M University System Method and ophthalmic composition for treating ocular hypertension and glaucoma with butyrophenones
IT1212742B (it) * 1983-05-17 1989-11-30 Dompe Farmaceutici Spa Derivati dibenzo [1,4]diazepinonici pirido [1,4] benzodiazepinonici,pirido [1,5] benzodiazepinonici e loro attivita' farmacologica
DE3409237A1 (de) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4886815A (en) * 1984-06-20 1989-12-12 Schachar Ronald A Treatment and prevention of retinal edema with dopaminergic antagonists
DE3626095A1 (de) * 1986-07-31 1988-02-11 Thomae Gmbh Dr K Neue substituierte pyrido(2,3-b)(1,4)benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JP3165436B2 (ja) * 1989-06-21 2001-05-14 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア 眼の発達の治療及び制御
US5066664A (en) * 1990-02-28 1991-11-19 Allergan, Inc. 2-(hydroxy-2-alkylphenylamino)-oxazolines and thiazolines as anti-glaucoma and vasoconstrictive agents
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5153205A (en) * 1990-10-01 1992-10-06 Merck & Co., Inc. Method to reduce introacular pressure without causing miosis

Also Published As

Publication number Publication date
EP0634932A1 (de) 1995-01-25
AU3810993A (en) 1993-10-21
WO1993018772A1 (en) 1993-09-30
ES2177543T3 (es) 2002-12-16
EP0634932B1 (de) 2002-06-19
US5716952A (en) 1998-02-10
JPH07504915A (ja) 1995-06-01
AU666536B2 (en) 1996-02-15
DE69332048D1 (de) 2002-07-25
DE69332048T2 (de) 2003-01-23

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Legal Events

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