ATE213631T1 - Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität - Google Patents
Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivitätInfo
- Publication number
- ATE213631T1 ATE213631T1 AT92911170T AT92911170T ATE213631T1 AT E213631 T1 ATE213631 T1 AT E213631T1 AT 92911170 T AT92911170 T AT 92911170T AT 92911170 T AT92911170 T AT 92911170T AT E213631 T1 ATE213631 T1 AT E213631T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridopyrane
- anxiolytic
- benzo
- derivatives
- anticonvulsive activity
- Prior art date
Links
- FEAVXMPFTQROEI-UHFFFAOYSA-N 2h-pyrano[3,2-b]pyridine Chemical class C1=CN=C2C=CCOC2=C1 FEAVXMPFTQROEI-UHFFFAOYSA-N 0.000 title 1
- 230000002082 anti-convulsion Effects 0.000 title 1
- 239000002249 anxiolytic agent Substances 0.000 title 1
- 230000000949 anxiolytic effect Effects 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919112721A GB9112721D0 (en) | 1991-06-13 | 1991-06-13 | Novel treatment |
| PCT/GB1992/001045 WO1992022293A1 (en) | 1991-06-13 | 1992-06-11 | Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE213631T1 true ATE213631T1 (de) | 2002-03-15 |
Family
ID=10696586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92911170T ATE213631T1 (de) | 1991-06-13 | 1992-06-11 | Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP0587645B1 (de) |
| JP (3) | JP3449716B2 (de) |
| KR (1) | KR100287969B1 (de) |
| AT (1) | ATE213631T1 (de) |
| AU (1) | AU660686B2 (de) |
| CA (1) | CA2111223C (de) |
| DE (1) | DE69232437T2 (de) |
| DK (1) | DK0587645T3 (de) |
| ES (1) | ES2173081T3 (de) |
| GB (1) | GB9112721D0 (de) |
| IE (2) | IE921910A1 (de) |
| MX (1) | MX9202803A (de) |
| NZ (2) | NZ264745A (de) |
| PT (1) | PT100583B (de) |
| SG (1) | SG48284A1 (de) |
| WO (1) | WO1992022293A1 (de) |
| ZA (1) | ZA924267B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453421A (en) * | 1992-09-11 | 1995-09-26 | E. R. Squibb & Sons, Inc. | Aryl and heterocyclic substituted propenamide derivatives |
| GB9225860D0 (en) * | 1992-12-11 | 1993-02-03 | Smithkline Beecham Plc | Novel treatment |
| DK0673374T3 (da) * | 1992-12-11 | 2000-07-31 | Smithkline Beecham Corp | Farmaceutisk præparat, der indeholder bicykliske forbindelsestyper |
| WO1995033726A1 (en) * | 1994-06-09 | 1995-12-14 | Ss Pharmaceutical Co., Ltd. | 4-quinolinone derivative or salt thereof |
| GB9411635D0 (en) | 1994-06-10 | 1994-08-03 | Smithkline Beecham Plc | Novel treatment |
| AU739678B2 (en) * | 1994-06-10 | 2001-10-18 | Smithkline Beecham Plc | Benzopyrans and their use as therapeutic agents |
| US5843989A (en) * | 1994-06-10 | 1998-12-01 | Smithkline Beecham P.L.C. | C4 -amide substituted compounds and their use as therapeutic agents |
| EP0764157B1 (de) * | 1994-06-10 | 2002-01-02 | Smithkline Beecham Plc | Benzopyrans und deren verwendung als therapeutische mittel |
| US6245893B1 (en) | 1994-12-17 | 2001-06-12 | Smithkline Beecham P.L.C. | Receptor that binds anti-convulsant compounds |
| GB9425502D0 (en) * | 1994-12-17 | 1995-02-15 | Smithkline Beecham Plc | Novel receptor |
| US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
| US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
| US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
| US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
| TR199802745T2 (xx) * | 1996-06-17 | 1999-04-21 | Smithkline Beecham Plc | �kameli benzamid t�revleri ve bunlar�n ihtiya�lar� durdurucu veya engelleyici maddeler olarak kullan�lmas�. |
| GB9619492D0 (en) * | 1996-09-18 | 1996-10-30 | Smithkline Beecham Plc | Novel treatment |
| DZ2446A1 (fr) * | 1997-03-18 | 2003-01-11 | Smithkline Beecham Plc | Nouveaux composés |
| GB9812683D0 (en) * | 1998-06-12 | 1998-08-12 | Smithkline Beecham Plc | Novel compounds |
| GB9813949D0 (en) * | 1998-06-29 | 1998-08-26 | Smithkline Beecham Plc | Novel compounds |
| EP3363463A3 (de) | 2004-01-07 | 2018-10-31 | Seikagaku Corporation | Hyaluronsäurederivat und arzneimittel damit |
| BRPI0519013A2 (pt) | 2004-12-13 | 2009-11-03 | Lilly Co Eli | composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2064514B (en) * | 1979-10-29 | 1984-01-18 | Maruko Pharmaceutical Co | Flavan compounds and acid addition salts thereof and pharmaceutical compositions thereof |
| DE3479726D1 (de) * | 1983-05-18 | 1989-10-19 | Beecham Group Plc | Benzopyran derivatives. |
| EP0205292B1 (de) * | 1985-06-08 | 1991-11-06 | Beecham Group Plc | Pyrano[3,2-c]pyridinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| PT84806B (pt) * | 1986-05-03 | 1989-12-29 | Beecham Group Plc | Processo para a preparacao de benzopiranos |
| FR2639349B1 (fr) * | 1988-11-23 | 1991-02-22 | Sanofi Sa | Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant |
-
1991
- 1991-06-13 GB GB919112721A patent/GB9112721D0/en active Pending
-
1992
- 1992-06-11 JP JP51078992A patent/JP3449716B2/ja not_active Expired - Fee Related
- 1992-06-11 NZ NZ264745A patent/NZ264745A/en unknown
- 1992-06-11 WO PCT/GB1992/001045 patent/WO1992022293A1/en not_active Ceased
- 1992-06-11 EP EP92911170A patent/EP0587645B1/de not_active Expired - Lifetime
- 1992-06-11 AT AT92911170T patent/ATE213631T1/de not_active IP Right Cessation
- 1992-06-11 CA CA002111223A patent/CA2111223C/en not_active Expired - Fee Related
- 1992-06-11 MX MX9202803A patent/MX9202803A/es not_active IP Right Cessation
- 1992-06-11 DE DE69232437T patent/DE69232437T2/de not_active Expired - Fee Related
- 1992-06-11 DK DK92911170T patent/DK0587645T3/da active
- 1992-06-11 EP EP01200951A patent/EP1108718A3/de not_active Withdrawn
- 1992-06-11 PT PT100583A patent/PT100583B/pt not_active IP Right Cessation
- 1992-06-11 SG SG1996008698A patent/SG48284A1/en unknown
- 1992-06-11 AU AU18917/92A patent/AU660686B2/en not_active Ceased
- 1992-06-11 KR KR1019930703872A patent/KR100287969B1/ko not_active Expired - Fee Related
- 1992-06-11 NZ NZ243108A patent/NZ243108A/en unknown
- 1992-06-11 ZA ZA924267A patent/ZA924267B/xx unknown
- 1992-06-11 ES ES92911170T patent/ES2173081T3/es not_active Expired - Lifetime
- 1992-07-01 IE IE191092A patent/IE921910A1/en not_active Application Discontinuation
- 1992-07-01 IE IE20020955A patent/IE20020955A1/en not_active IP Right Cessation
-
2002
- 2002-01-24 JP JP2002015835A patent/JP2002255958A/ja active Pending
-
2003
- 2003-09-03 JP JP2003311700A patent/JP2004002478A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR940701252A (ko) | 1994-05-28 |
| AU660686B2 (en) | 1995-07-06 |
| JPH06507893A (ja) | 1994-09-08 |
| MX9202803A (es) | 1992-12-01 |
| NZ243108A (en) | 1996-08-27 |
| AU1891792A (en) | 1993-01-12 |
| CA2111223A1 (en) | 1992-12-23 |
| EP1108718A3 (de) | 2003-02-05 |
| CA2111223C (en) | 1998-06-09 |
| EP0587645B1 (de) | 2002-02-27 |
| DE69232437T2 (de) | 2002-10-31 |
| EP1108718A2 (de) | 2001-06-20 |
| WO1992022293A1 (en) | 1992-12-23 |
| PT100583A (pt) | 1993-09-30 |
| NZ264745A (en) | 1997-03-24 |
| IE20020955A1 (en) | 2003-10-01 |
| HK1019004A1 (en) | 2000-01-14 |
| PT100583B (pt) | 1999-07-30 |
| SG48284A1 (en) | 1998-04-17 |
| EP0587645A1 (de) | 1994-03-23 |
| KR100287969B1 (ko) | 2001-05-02 |
| JP3449716B2 (ja) | 2003-09-22 |
| IE921910A1 (en) | 1992-12-16 |
| DE69232437D1 (de) | 2002-04-04 |
| DK0587645T3 (da) | 2002-06-03 |
| GB9112721D0 (en) | 1991-07-31 |
| JP2004002478A (ja) | 2004-01-08 |
| JP2002255958A (ja) | 2002-09-11 |
| ES2173081T3 (es) | 2002-10-16 |
| ZA924267B (en) | 1993-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0587645 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |