ATE219140T1 - Filtervorrichtung - Google Patents

Filtervorrichtung

Info

Publication number
ATE219140T1
ATE219140T1 AT96908752T AT96908752T ATE219140T1 AT E219140 T1 ATE219140 T1 AT E219140T1 AT 96908752 T AT96908752 T AT 96908752T AT 96908752 T AT96908752 T AT 96908752T AT E219140 T1 ATE219140 T1 AT E219140T1
Authority
AT
Austria
Prior art keywords
filter device
hepatocytes
entrapped
single cells
hollow fibers
Prior art date
Application number
AT96908752T
Other languages
English (en)
Inventor
Wei-Shou Hu
Frank Bernard Cerra
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Application granted granted Critical
Publication of ATE219140T1 publication Critical patent/ATE219140T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1625—Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)
  • Centrifugal Separators (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT96908752T 1995-03-31 1996-03-21 Filtervorrichtung ATE219140T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/414,499 US5595909A (en) 1988-05-23 1995-03-31 Filter device
PCT/US1996/003316 WO1996030492A1 (en) 1995-03-31 1996-03-21 Filter device

Publications (1)

Publication Number Publication Date
ATE219140T1 true ATE219140T1 (de) 2002-06-15

Family

ID=23641714

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96908752T ATE219140T1 (de) 1995-03-31 1996-03-21 Filtervorrichtung

Country Status (7)

Country Link
US (1) US5595909A (de)
EP (1) EP0817833B1 (de)
JP (1) JP3692147B2 (de)
AT (1) ATE219140T1 (de)
CA (1) CA2215071A1 (de)
DE (1) DE69621790T2 (de)
WO (1) WO1996030492A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US6372482B1 (en) * 1997-01-16 2002-04-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Device and method for performing a biological modification of a fluid
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
US6653105B2 (en) * 1998-02-11 2003-11-25 Vitagen, Inc. Clonal cells and cell lines derived from C3A cells and methods of making and using them
DE69903800T2 (de) 1998-03-18 2003-10-02 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6068775A (en) * 1998-04-13 2000-05-30 Circe Biomedical, Inc. Removal of agent from cell suspension
EP0953633A1 (de) * 1998-04-28 1999-11-03 Livercell L.L.C. Zellkulturverfahren und Medium zur Herstellung von vermehrungsfähige, normale, differenzierte Humane Leberzellen
JP4222658B2 (ja) * 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
US6436120B1 (en) 1999-04-20 2002-08-20 Allen J. Meglin Vena cava filter
US6080178A (en) * 1999-04-20 2000-06-27 Meglin; Allen J. Vena cava filter
DE10023505A1 (de) * 2000-05-13 2001-11-22 Fraunhofer Ges Forschung Reaktormodul mit Kapillarmembranen
ATE419024T1 (de) * 2000-10-12 2009-01-15 Renal Solutions Inc Vorrichtung für die kontrolle des flusses von körperflüssigkeiten bei extrakorporalen flüssigkeitsbehandlungen
AU2002213197A1 (en) * 2000-10-12 2002-04-22 Massachusetts General Hospital Plasma supplement and use in liver assist systems
US7033498B2 (en) * 2000-11-28 2006-04-25 Renal Solutions, Inc. Cartridges useful in cleaning dialysis solutions
US6627164B1 (en) * 2000-11-28 2003-09-30 Renal Solutions, Inc. Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
US7456018B2 (en) 2001-07-06 2008-11-25 Philippe Gripon Human hepatoma lines, methods for obtaining same and uses thereof
GB0121986D0 (en) * 2001-09-11 2001-10-31 Isis Innovation Method and structure for growing living organic tissue
US20040058309A1 (en) * 2001-10-12 2004-03-25 Junji Washizu Plasma supplement and use in liver assist systems
US6878283B2 (en) * 2001-11-28 2005-04-12 Renal Solutions, Inc. Filter cartridge assemblies and methods for filtering fluids
AU2003228348A1 (en) * 2002-03-20 2003-10-08 John T. Fassett Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
US7160719B2 (en) * 2002-06-07 2007-01-09 Mayo Foundation For Medical Education And Research Bioartificial liver system
US7998101B2 (en) * 2003-07-28 2011-08-16 Renal Solutions, Inc. Devices and methods for body fluid flow control in extracorporeal fluid treatment
US7056286B2 (en) * 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
JP2007525984A (ja) * 2004-03-05 2007-09-13 ディーエスエム アイピー アセッツ ビー．ブイ． 連続的灌流および交互接線流による細胞培養の方法
PT1773978E (pt) * 2004-05-19 2014-05-29 Massachusetts Inst Technology Modelo de doença com células/tecidos tri-dimensionais perfundidos
EP1743522A1 (de) * 2005-07-13 2007-01-17 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Tiermodelle für Typ-II Diabetes und X-Syndrom
US8865460B2 (en) 2005-08-12 2014-10-21 Clemson University Research Foundation Co-culture bioreactor system
KR101685246B1 (ko) 2006-07-14 2016-12-09 디피엑스 홀딩스 비.브이. 개선된 세포 배양 방법
ATE545441T1 (de) * 2007-06-13 2012-03-15 Pervasis Therapeutics Inc Verfahren und vorrichtungen zur minimal invasiven abgabe von zellhaltigen fliessfähigen zusammensetzungen
WO2009108654A2 (en) * 2008-02-25 2009-09-03 Clemson University Differential pressure pump system
CN102421467B (zh) 2009-03-13 2015-04-22 梅约医学教育与研究基金会 生物人工肝
EP2496189A4 (de) * 2009-11-04 2016-05-11 Nitinol Devices And Components Inc Entwurf für einen stent mit alternierender ringförmiger brücke und verwendungsverfahren dafür
EP2624791B1 (de) * 2010-10-08 2017-06-21 Confluent Medical Technologies, Inc. Stent mit alternierender ringförmiger brücke
EP2625263B1 (de) 2010-10-08 2020-03-11 Terumo BCT, Inc. Konfigurierbare verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
WO2015073918A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3122866B1 (de) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passives ersetzen von medien
EP3198006B1 (de) 2014-09-26 2021-03-24 Terumo BCT, Inc. Geplante fütterung
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
EP3498822B1 (de) * 2016-08-10 2021-11-10 Cyberdyne Inc. Verfahren zur herstellung dreidimensionaler zellstrukturen und system zur herstellung einer dreidimensionalen struktur
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
EP3705564A1 (de) 2019-03-06 2020-09-09 Cherry Biotech SAS Verfahren und vorrichtung zur umgebungskontrolle in biologischen proben, die in zellkulturschalen enthalten sind

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE120485T1 (de) * 1988-05-23 1995-04-15 Univ Minnesota Bioreaktor.
JPH0271755A (ja) * 1988-09-07 1990-03-12 Terumo Corp 人工肝臓装置
JPH0292270A (ja) * 1988-09-30 1990-04-03 Terumo Corp 細胞培養装置
DE4206585C2 (de) * 1992-03-03 1994-11-24 Augustinus Dr Med Bader Vorrichtung zur Massenkultur von Zellen
DE4322746A1 (de) * 1993-07-08 1995-01-12 Augustinus Dr Med Bader Verfahren und Vorrichtung zur Behandlung von Zellkulturen

Also Published As

Publication number Publication date
WO1996030492A1 (en) 1996-10-03
JP3692147B2 (ja) 2005-09-07
EP0817833A1 (de) 1998-01-14
DE69621790T2 (de) 2003-02-20
EP0817833A4 (de) 1998-11-04
US5595909A (en) 1997-01-21
EP0817833B1 (de) 2002-06-12
CA2215071A1 (en) 1996-10-03
JPH11502712A (ja) 1999-03-09
DE69621790D1 (de) 2002-07-18

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