ATE21897T1 - Verfahren zur herstellung von (thienyl-2)- und (thienyl-3)-2 aethylamin-derivaten und so erhaltene verbindungen. - Google Patents
Verfahren zur herstellung von (thienyl-2)- und (thienyl-3)-2 aethylamin-derivaten und so erhaltene verbindungen.Info
- Publication number
- ATE21897T1 ATE21897T1 AT82401095T AT82401095T ATE21897T1 AT E21897 T1 ATE21897 T1 AT E21897T1 AT 82401095 T AT82401095 T AT 82401095T AT 82401095 T AT82401095 T AT 82401095T AT E21897 T1 ATE21897 T1 AT E21897T1
- Authority
- AT
- Austria
- Prior art keywords
- amino
- thienyl
- opt
- alkoxy
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 thiophene-carbonyl Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- OJYDKYKQCVPTFG-UHFFFAOYSA-N 2,3,3a,4-tetrahydrothieno[3,2-c]pyridine Chemical class C1N=CC=C2SCCC21 OJYDKYKQCVPTFG-UHFFFAOYSA-N 0.000 abstract 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- 206010034962 Photopsia Diseases 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910000102 alkali metal hydride Inorganic materials 0.000 abstract 1
- 150000008046 alkali metal hydrides Chemical class 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004986 diarylamino group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 229910000065 phosphene Inorganic materials 0.000 abstract 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 abstract 1
- 125000005541 phosphonamide group Chemical group 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5004—Acyclic saturated phosphines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Saccharide Compounds (AREA)
- Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8113062A FR2508453A1 (fr) | 1981-06-30 | 1981-06-30 | Procede de preparation de derives des (thienyl-2)- et thienyl-3)-2 ethylamines et produits ainsi obtenus |
| EP82401095A EP0068978B1 (de) | 1981-06-30 | 1982-06-16 | Verfahren zur Herstellung von (thienyl-2)- und (thienyl-3)-2 Äthylamin-Derivaten und so erhaltene Verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE21897T1 true ATE21897T1 (de) | 1986-09-15 |
Family
ID=9260129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82401095T ATE21897T1 (de) | 1981-06-30 | 1982-06-16 | Verfahren zur herstellung von (thienyl-2)- und (thienyl-3)-2 aethylamin-derivaten und so erhaltene verbindungen. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4482718A (de) |
| EP (1) | EP0068978B1 (de) |
| JP (1) | JPS5810574A (de) |
| KR (1) | KR840000536A (de) |
| AT (1) | ATE21897T1 (de) |
| AU (1) | AU566802B2 (de) |
| CA (1) | CA1205810A (de) |
| CS (1) | CS248028B2 (de) |
| DD (1) | DD206377A5 (de) |
| DE (1) | DE3273015D1 (de) |
| DK (1) | DK286682A (de) |
| ES (1) | ES514221A0 (de) |
| FI (1) | FI822315L (de) |
| FR (1) | FR2508453A1 (de) |
| GR (1) | GR76496B (de) |
| HU (1) | HU194860B (de) |
| IE (1) | IE53228B1 (de) |
| IL (1) | IL65980A (de) |
| NO (1) | NO155136C (de) |
| NZ (1) | NZ200852A (de) |
| PT (1) | PT75152B (de) |
| SU (1) | SU1148563A3 (de) |
| YU (1) | YU143382A (de) |
| ZA (1) | ZA824624B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2508454A1 (fr) * | 1981-06-30 | 1982-12-31 | Sanofi Sa | Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines et produits ainsi obtenus |
| CA1242718A (en) * | 1983-11-21 | 1988-10-04 | John R. Carson | Acetylene derivatives and methods for the treatment of hypertension and angina |
| CA1292747C (en) * | 1983-11-21 | 1991-12-03 | John Robert Carson | Aralykyl (arylethynyl) aralkyl amines and their use as vasodilators and antihypertensives |
| FR2622191B1 (fr) * | 1987-10-22 | 1991-06-21 | Sanofi Sa | Procede de preparation de la n-(chloro-2 benzyl)-2 ethylamine et produits intermediaires dans cette preparation |
| JPH0283380A (ja) * | 1988-09-21 | 1990-03-23 | Kotobuki Seiyaku Kk | 新規ジアミン誘導体、抗不整脈剤及びその製法 |
| US4900539A (en) * | 1988-12-22 | 1990-02-13 | The United States Of America As Represented By The United States Department Of Energy | Radiohalogenated thienylethylamine derivatives for evaluating local cerebral blood flow |
| EP0596120A4 (en) * | 1991-08-09 | 1994-07-06 | Yoshitomi Pharmaceutical | Thiophene compound. |
| US9012660B2 (en) * | 2011-08-17 | 2015-04-21 | Shandong Luye Pharmaceutical Co., Ltd. | 5,6,7,8-tetrahydro-6-[N,N-bis[(2-thienyl)ethyl]] amino-1-naphthol, and preparing method and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2983729A (en) * | 1958-04-30 | 1961-05-09 | Monsanto Chemicals | Preparation of 5-halothienyl amines |
| FR2300090A1 (fr) * | 1975-02-07 | 1976-09-03 | Parcor | Procede de preparation de derives de la thienopyridine |
| US4127580A (en) * | 1975-02-07 | 1978-11-28 | Parcor | Process for the preparation of thieno-pyridine derivatives |
| FR2315274A1 (fr) * | 1975-06-27 | 1977-01-21 | Parcor | Nouveaux derives de la thieno (2,3-c) pyridine, leur preparation et leurs applications |
| IT1082336B (it) * | 1977-01-27 | 1985-05-21 | Medea Res Srl | Processo per la preparazione della 5.2.clorobenzil.4 5 6 7.tetraidro tien 3 2.c.piridina |
-
1981
- 1981-06-30 FR FR8113062A patent/FR2508453A1/fr active Granted
-
1982
- 1982-06-01 IE IE1310/82A patent/IE53228B1/en unknown
- 1982-06-04 NZ NZ200852A patent/NZ200852A/xx unknown
- 1982-06-06 IL IL65980A patent/IL65980A/xx unknown
- 1982-06-09 GR GR68374A patent/GR76496B/el unknown
- 1982-06-10 ES ES514221A patent/ES514221A0/es active Granted
- 1982-06-10 AU AU84755/82A patent/AU566802B2/en not_active Ceased
- 1982-06-16 AT AT82401095T patent/ATE21897T1/de active
- 1982-06-16 EP EP82401095A patent/EP0068978B1/de not_active Expired
- 1982-06-16 DE DE8282401095T patent/DE3273015D1/de not_active Expired
- 1982-06-25 DK DK286682A patent/DK286682A/da not_active Application Discontinuation
- 1982-06-29 NO NO822224A patent/NO155136C/no unknown
- 1982-06-29 SU SU823459385A patent/SU1148563A3/ru active
- 1982-06-29 PT PT75152A patent/PT75152B/pt not_active IP Right Cessation
- 1982-06-29 US US06/393,387 patent/US4482718A/en not_active Expired - Fee Related
- 1982-06-29 FI FI822315A patent/FI822315L/fi not_active Application Discontinuation
- 1982-06-29 CS CS824895A patent/CS248028B2/cs unknown
- 1982-06-29 DD DD82241200A patent/DD206377A5/de unknown
- 1982-06-29 ZA ZA824624A patent/ZA824624B/xx unknown
- 1982-06-29 HU HU822107A patent/HU194860B/hu unknown
- 1982-06-29 CA CA000406290A patent/CA1205810A/en not_active Expired
- 1982-06-30 KR KR1019820002912A patent/KR840000536A/ko unknown
- 1982-06-30 JP JP57113843A patent/JPS5810574A/ja active Pending
- 1982-06-30 YU YU01433/82A patent/YU143382A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8475582A (en) | 1983-01-06 |
| IE821310L (en) | 1982-12-30 |
| HU194860B (en) | 1988-03-28 |
| NO155136C (no) | 1987-02-18 |
| IL65980A (en) | 1985-12-31 |
| NO822224L (no) | 1983-01-03 |
| FR2508453B1 (de) | 1983-12-23 |
| FI822315L (fi) | 1982-12-31 |
| CS248028B2 (en) | 1987-01-15 |
| US4482718A (en) | 1984-11-13 |
| ES8305349A1 (es) | 1983-04-01 |
| GR76496B (de) | 1984-08-10 |
| DK286682A (da) | 1982-12-31 |
| EP0068978B1 (de) | 1986-09-03 |
| PT75152B (fr) | 1984-05-29 |
| PT75152A (fr) | 1982-07-01 |
| NO155136B (no) | 1986-11-10 |
| CA1205810A (en) | 1986-06-10 |
| NZ200852A (en) | 1985-09-13 |
| ZA824624B (en) | 1983-04-27 |
| KR840000536A (ko) | 1984-02-25 |
| FR2508453A1 (fr) | 1982-12-31 |
| AU566802B2 (en) | 1987-10-29 |
| ES514221A0 (es) | 1983-04-01 |
| YU143382A (en) | 1984-12-31 |
| IL65980A0 (en) | 1982-09-30 |
| IE53228B1 (en) | 1988-09-14 |
| SU1148563A3 (ru) | 1985-03-30 |
| JPS5810574A (ja) | 1983-01-21 |
| EP0068978A1 (de) | 1983-01-05 |
| FI822315A0 (fi) | 1982-06-29 |
| DE3273015D1 (en) | 1986-10-09 |
| DD206377A5 (de) | 1984-01-25 |
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