ATE218547T1 - Acylierte derivate von melatonin und dessen analoge als arzneimittel - Google Patents
Acylierte derivate von melatonin und dessen analoge als arzneimittelInfo
- Publication number
- ATE218547T1 ATE218547T1 AT96928490T AT96928490T ATE218547T1 AT E218547 T1 ATE218547 T1 AT E218547T1 AT 96928490 T AT96928490 T AT 96928490T AT 96928490 T AT96928490 T AT 96928490T AT E218547 T1 ATE218547 T1 AT E218547T1
- Authority
- AT
- Austria
- Prior art keywords
- melatonin
- analogues
- medicinal products
- acylated derivatives
- acylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9509611A FR2737725B1 (fr) | 1995-08-08 | 1995-08-08 | Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament |
PCT/FR1996/001260 WO1997006140A1 (fr) | 1995-08-08 | 1996-08-07 | Derives acyles de la melatonine et d'analogues en tant que medicament |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE218547T1 true ATE218547T1 (de) | 2002-06-15 |
Family
ID=9481785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96928490T ATE218547T1 (de) | 1995-08-08 | 1996-08-07 | Acylierte derivate von melatonin und dessen analoge als arzneimittel |
Country Status (14)
Country | Link |
---|---|
US (2) | US6004991A (de) |
EP (1) | EP0851855B9 (de) |
JP (1) | JP4061658B2 (de) |
CN (1) | CN1118451C (de) |
AR (1) | AR003220A1 (de) |
AT (1) | ATE218547T1 (de) |
AU (1) | AU6823696A (de) |
DE (1) | DE69621626T2 (de) |
DK (1) | DK0851855T3 (de) |
ES (1) | ES2176480T3 (de) |
FR (1) | FR2737725B1 (de) |
PT (1) | PT851855E (de) |
WO (1) | WO1997006140A1 (de) |
ZA (1) | ZA966751B (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2738818B1 (fr) * | 1995-09-18 | 1997-12-05 | Valentonine | Nouveaux derives d'oxydation d'indolylalkylamines, et leur utilisation a titre de medicament |
US5981550A (en) * | 1997-06-05 | 1999-11-09 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
FR2771739B1 (fr) * | 1997-11-28 | 2001-04-20 | Adir | Nouveaux composes naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2784375B1 (fr) * | 1998-10-12 | 2000-11-24 | Adir | Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2787447B1 (fr) * | 1998-12-18 | 2001-03-23 | Centre Nat Rech Scient | Nouveaux derives de melatonine et medicament comprenant de tels derives |
WO2000065588A1 (en) * | 1999-04-22 | 2000-11-02 | Castlewood Systems, Inc. | Improved motor and spindle design |
FR2792937B1 (fr) * | 1999-04-27 | 2001-08-10 | Cemaf | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
US6306890B1 (en) * | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
MXPA03000729A (es) * | 2000-07-28 | 2004-11-01 | Inspire Pharmaceuticals Inc | Metodo para reducir la presion intraocular utilizando derivados de indol. |
ES2172415B2 (es) | 2000-07-28 | 2003-11-16 | Univ Madrid Complutense | Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina. |
US7062092B2 (en) | 2000-08-22 | 2006-06-13 | Affymetrix, Inc. | System, method, and computer software product for gain adjustment in biological microarray scanner |
US6638966B2 (en) * | 2000-09-19 | 2003-10-28 | University Of Iowa Research Foundation | Use of melatonin analogues for induction of general anesthesia |
US6552064B2 (en) * | 2000-09-19 | 2003-04-22 | University Of Iowa Research Foundation | Use of melatonin for induction of general anesthesia |
EP1370527A1 (de) | 2001-03-06 | 2003-12-17 | AstraZeneca AB | Indolonderivate mit gefässschädigender aktivität |
JP4156825B2 (ja) * | 2001-11-01 | 2008-09-24 | 株式会社ロッテ | 抗鬱・抗ストレス剤及びそれを含有する組成物 |
US6913200B2 (en) | 2002-11-20 | 2005-07-05 | Agilent Technologies, Inc. | Scanning parameterization for biopolymeric array scanner |
WO2004085392A1 (en) * | 2003-03-25 | 2004-10-07 | Faust Pharmaceuticals | Melatonin derivatives and their use for treating neurological dysfunctions |
WO2004085395A1 (en) * | 2003-03-25 | 2004-10-07 | Faust Pharmaceuticals | Melatonin derivatives and their use for treating neurological dysfunctions |
US7361681B2 (en) * | 2003-03-28 | 2008-04-22 | Sygnis Bioscience Gmbh & Co. Kg | Method of treating amytrophic lateral sclerosis using melatonin |
JP2007524630A (ja) * | 2003-06-25 | 2007-08-30 | バンダービルト・ユニバーシティ | Cox−2標的造影剤 |
WO2005063240A1 (en) * | 2003-12-22 | 2005-07-14 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of hypertension |
US7674816B2 (en) * | 2003-12-23 | 2010-03-09 | Abraxis Bioscience, Llc | Substituted melatonin derivatives, process for their preparation, and methods of use |
FR2866335B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
WO2006032987A1 (en) * | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Indoline compounds and their use in the treatment of arteriosclerosis |
US20060223877A1 (en) * | 2005-03-31 | 2006-10-05 | Zemlan Frank P | Methods of treatment utilizing certain melatonin derivatives |
EP1871754A1 (de) * | 2005-04-22 | 2008-01-02 | Wyeth a Corporation of the State of Delaware | Dihydrobenzofuran-derivate und verwendungen dafür |
FR2898358B1 (fr) * | 2006-03-08 | 2008-05-30 | Macef Sa | Association d'un antagoniste du recepteur 5ht2 et d'activateur du recepteur 5ht2 par modulation allosterique et leurs utilisations comme produits medicaux |
CN101528222A (zh) * | 2006-06-19 | 2009-09-09 | 范德比尔特大学 | 用于诊断性和治疗性靶向cox-2的方法和组合物 |
FR2903102B1 (fr) * | 2006-06-30 | 2010-08-13 | Servier Lab | Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2903103B1 (fr) * | 2006-06-30 | 2010-08-13 | Servier Lab | Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2907451B1 (fr) * | 2006-10-18 | 2008-12-12 | Servier Lab | "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
JP5380170B2 (ja) * | 2009-06-17 | 2014-01-08 | 正徳 染井 | N−アシルトリプタミンを含有する組成物 |
WO2013013060A1 (en) * | 2011-07-19 | 2013-01-24 | Lycus, Llc | Agomelatine derivatives |
EP3078374B1 (de) | 2011-10-17 | 2019-06-19 | Vanderbilt University | Indomethacin-analoga zur behandlung von kastrationsresistentem prostatakrebs |
US20140256767A1 (en) | 2011-10-31 | 2014-09-11 | The Broad Institute, Inc. | Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators |
AR091699A1 (es) | 2012-07-10 | 2015-02-25 | Astellas Pharma Inc | Derivado de indol carboxamida |
MX2020005736A (es) | 2013-04-12 | 2021-06-14 | Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises | Derivados de glutarimida, uso de los mismos, composicion farmaceutica basada en los mismos y metodos para producir derivados de glutarimida. |
JP5705939B2 (ja) * | 2013-09-30 | 2015-04-22 | 染井 正徳 | N−アシルトリプタミンを含有する組成物 |
CN105085367B (zh) * | 2014-05-03 | 2019-05-21 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
RU2692239C2 (ru) * | 2017-01-30 | 2019-06-24 | Общество с ограниченной ответственностью "ОФТАМЕЛАТ" | Производные 2,3-дигидро-1Н-индола, обладающие свойствами лигандов мелатониновых рецепторов, способ получения и применение |
CN109251151A (zh) * | 2017-07-12 | 2019-01-22 | 北京广为医药科技有限公司 | N-(2-(取代-萘-1-基)乙基)取代酰胺类化合物、其制备及其用途 |
JP7093961B2 (ja) * | 2018-02-13 | 2022-07-01 | 国立大学法人金沢大学 | ストレス低減薬剤 |
CN114736149B (zh) * | 2019-03-08 | 2023-04-18 | 哈尔滨商业大学 | 一种2,3-二氢色胺类化合物的合成方法 |
RU2751048C1 (ru) * | 2020-05-29 | 2021-07-07 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Южно-Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ЮУГМУ Минздрава России) | Средство в виде пленки лекарственной, содержащей мелатонин, для лечения термической травмы |
WO2022115960A1 (en) | 2020-12-04 | 2022-06-09 | Magicmed Industries Inc. | Aldehyde and ketone derivatives of psilocybin and methods of using |
WO2023201421A1 (en) * | 2022-04-19 | 2023-10-26 | Mindset Pharma Inc. | Indoline derivatives as serotonergic agents useful for the treatment of disorders related thereto |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093352A (en) * | 1988-11-14 | 1992-03-03 | Whitby Research, Inc. | Antidepressant agents |
FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5525442A (en) * | 1990-09-14 | 1996-06-11 | Westinghouse Electric Corporation | Alkali metal battery |
FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
IT1255199B (it) * | 1992-07-01 | 1995-10-20 | Franco Fraschini | Farmaco sintetizzato analogo della melatonina particolarmente efficacenelle patologie che interferiscono con i ritmi circadiani |
US5403851A (en) * | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
-
1995
- 1995-08-08 FR FR9509611A patent/FR2737725B1/fr not_active Expired - Fee Related
-
1996
- 1996-08-07 JP JP50818497A patent/JP4061658B2/ja not_active Expired - Fee Related
- 1996-08-07 DE DE69621626T patent/DE69621626T2/de not_active Expired - Lifetime
- 1996-08-07 DK DK96928490T patent/DK0851855T3/da active
- 1996-08-07 CN CN96196943A patent/CN1118451C/zh not_active Expired - Fee Related
- 1996-08-07 EP EP96928490A patent/EP0851855B9/de not_active Expired - Lifetime
- 1996-08-07 WO PCT/FR1996/001260 patent/WO1997006140A1/fr active IP Right Grant
- 1996-08-07 US US09/011,042 patent/US6004991A/en not_active Expired - Fee Related
- 1996-08-07 ES ES96928490T patent/ES2176480T3/es not_active Expired - Lifetime
- 1996-08-07 AT AT96928490T patent/ATE218547T1/de not_active IP Right Cessation
- 1996-08-07 PT PT96928490T patent/PT851855E/pt unknown
- 1996-08-07 AU AU68236/96A patent/AU6823696A/en not_active Abandoned
- 1996-08-08 AR ARP960103925A patent/AR003220A1/es active IP Right Grant
- 1996-08-08 ZA ZA9606751A patent/ZA966751B/xx unknown
-
1999
- 1999-04-16 US US09/292,968 patent/US6140372A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT851855E (pt) | 2002-10-31 |
AR003220A1 (es) | 1998-07-08 |
CN1196049A (zh) | 1998-10-14 |
DE69621626D1 (de) | 2002-07-11 |
WO1997006140A1 (fr) | 1997-02-20 |
FR2737725A1 (fr) | 1997-02-14 |
DE69621626T2 (de) | 2003-02-06 |
FR2737725B1 (fr) | 1997-10-31 |
CN1118451C (zh) | 2003-08-20 |
DK0851855T3 (da) | 2002-09-23 |
EP0851855A1 (de) | 1998-07-08 |
ZA966751B (en) | 1997-11-03 |
ES2176480T3 (es) | 2002-12-01 |
US6140372A (en) | 2000-10-31 |
AU6823696A (en) | 1997-03-05 |
US6004991A (en) | 1999-12-21 |
EP0851855B1 (de) | 2002-06-05 |
JP4061658B2 (ja) | 2008-03-19 |
JPH11510804A (ja) | 1999-09-21 |
EP0851855B9 (de) | 2003-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |