ATE213650T1 - Inklusionskomplexe von radiohalogenierten fettsäuren in einer zyklodextrine - Google Patents
Inklusionskomplexe von radiohalogenierten fettsäuren in einer zyklodextrineInfo
- Publication number
- ATE213650T1 ATE213650T1 AT95940305T AT95940305T ATE213650T1 AT E213650 T1 ATE213650 T1 AT E213650T1 AT 95940305 T AT95940305 T AT 95940305T AT 95940305 T AT95940305 T AT 95940305T AT E213650 T1 ATE213650 T1 AT E213650T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclodextrin
- fatty acid
- pct
- date
- radio
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 6
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 6
- 229930195729 fatty acid Natural products 0.000 title abstract 6
- 239000000194 fatty acid Substances 0.000 title abstract 6
- 150000004665 fatty acids Chemical class 0.000 title abstract 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 4
- IEYFRQLMJACEQY-UHFFFAOYSA-N 16-iodo-3-methylhexadecanoic acid Chemical compound OC(=O)CC(C)CCCCCCCCCCCCCI IEYFRQLMJACEQY-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 239000001116 FEMA 4028 Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 1
- 239000012217 radiopharmaceutical Substances 0.000 abstract 1
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1268—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9413609A FR2726765B1 (fr) | 1994-11-14 | 1994-11-14 | Compositions radiopharmaceutiques comprenant un complexe d'inclusion d'une cyclodextrine et d'un acide gras radiohalogene |
| PCT/FR1995/001489 WO1996014881A1 (fr) | 1994-11-14 | 1995-11-13 | Complexe d'inclusion d'un acide gras radiohalogene dans une cyclodextrine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE213650T1 true ATE213650T1 (de) | 2002-03-15 |
Family
ID=9468773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95940305T ATE213650T1 (de) | 1994-11-14 | 1995-11-13 | Inklusionskomplexe von radiohalogenierten fettsäuren in einer zyklodextrine |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5993776A (de) |
| EP (1) | EP0794802B1 (de) |
| AT (1) | ATE213650T1 (de) |
| DE (1) | DE69525647T2 (de) |
| FR (1) | FR2726765B1 (de) |
| WO (1) | WO1996014881A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2792942B1 (fr) | 1999-04-29 | 2001-06-08 | Commissariat Energie Atomique | Cyclodextrines amphiphiles, leur preparation et leur utilisation pour solubiliser des systemes organises et incorporer des molecules hydrophobes |
| GB201915206D0 (en) | 2019-10-21 | 2019-12-04 | Ge Healthcare Ltd | Use of cyclodextrins as a radiostabilizer |
| TWI832684B (zh) | 2022-01-27 | 2024-02-11 | 美商恩特葛瑞斯股份有限公司 | 用於儲存分子二硼烷的系統及方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2508902B1 (fr) * | 1981-07-02 | 1985-09-06 | Commissariat Energie Atomique | Procede de preparation extemporanee d'un acide gras injectable, marque a l'iode radioactif et preparation de derives iodes utilisables pour la mise en oeuvre de ce procede |
| EP0153403A4 (de) * | 1983-08-17 | 1985-12-11 | Mallinckrodt Inc | Chemische verbindungen. |
| CA1221105A (en) * | 1983-09-16 | 1987-04-28 | Alfred H. Dougan | Omega halogenated fatty acids |
| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| US5068226A (en) * | 1987-12-07 | 1991-11-26 | Cyclex, Inc. | Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| MY106598A (en) * | 1988-08-31 | 1995-06-30 | Australian Commercial Res & Development Ltd | Compositions and methods for drug delivery and chromatography. |
| US5068227A (en) * | 1989-01-18 | 1991-11-26 | Cyclex, Inc. | Cyclodextrins as carriers |
| US5321014A (en) * | 1991-06-28 | 1994-06-14 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular encapsulation and delivery of alkenes alkynes and long chain alkanes, to living mammalian cells |
| US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
| JP2715240B2 (ja) * | 1993-05-18 | 1998-02-18 | 株式会社第一ラジオアイソトープ研究所 | 放射性ヨウ素標識脂肪酸−シクロデキストリン複合体およびこれを含有するイメージング剤 |
| GB9325330D0 (en) * | 1993-12-10 | 1994-02-16 | Univ Toronto | Fluorocyclodextrin drug delivery system |
-
1994
- 1994-11-14 FR FR9413609A patent/FR2726765B1/fr not_active Expired - Fee Related
-
1995
- 1995-11-13 AT AT95940305T patent/ATE213650T1/de not_active IP Right Cessation
- 1995-11-13 WO PCT/FR1995/001489 patent/WO1996014881A1/fr not_active Ceased
- 1995-11-13 US US08/836,196 patent/US5993776A/en not_active Expired - Fee Related
- 1995-11-13 DE DE69525647T patent/DE69525647T2/de not_active Expired - Fee Related
- 1995-11-13 EP EP95940305A patent/EP0794802B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996014881A1 (fr) | 1996-05-23 |
| DE69525647D1 (de) | 2002-04-04 |
| FR2726765A1 (fr) | 1996-05-15 |
| EP0794802B1 (de) | 2002-02-27 |
| DE69525647T2 (de) | 2002-10-17 |
| FR2726765B1 (fr) | 1996-12-20 |
| EP0794802A1 (de) | 1997-09-17 |
| US5993776A (en) | 1999-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |