ATE212997T1 - Festphasensynthese von oligonucleotid n3'-p5'- phosphoramidaten - Google Patents

Festphasensynthese von oligonucleotid n3'-p5'- phosphoramidaten

Info

Publication number
ATE212997T1
ATE212997T1 AT96919449T AT96919449T ATE212997T1 AT E212997 T1 ATE212997 T1 AT E212997T1 AT 96919449 T AT96919449 T AT 96919449T AT 96919449 T AT96919449 T AT 96919449T AT E212997 T1 ATE212997 T1 AT E212997T1
Authority
AT
Austria
Prior art keywords
dna
oligonucleotide
phosphoramidate
solid phase
phase synthesis
Prior art date
Application number
AT96919449T
Other languages
English (en)
Inventor
Bernard L Hirschbein
Karen L Fearon
Sergei M Gryaznov
Sarah N Mccurdy
Jeffrey S Nelson
Ronald G Schultz
Original Assignee
Lynx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lynx Therapeutics Inc filed Critical Lynx Therapeutics Inc
Application granted granted Critical
Publication of ATE212997T1 publication Critical patent/ATE212997T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT96919449T 1996-02-21 1996-06-14 Festphasensynthese von oligonucleotid n3'-p5'- phosphoramidaten ATE212997T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/603,566 US5684143A (en) 1996-02-21 1996-02-21 Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
PCT/US1996/010418 WO1997031009A1 (en) 1996-02-21 1996-06-14 Solid phase synthesis of oligonucleotide n3'→p5' phosphoramidates

Publications (1)

Publication Number Publication Date
ATE212997T1 true ATE212997T1 (de) 2002-02-15

Family

ID=24415986

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919449T ATE212997T1 (de) 1996-02-21 1996-06-14 Festphasensynthese von oligonucleotid n3'-p5'- phosphoramidaten

Country Status (7)

Country Link
US (2) US5684143A (de)
EP (1) EP0882059B1 (de)
AT (1) ATE212997T1 (de)
CZ (1) CZ262998A3 (de)
DE (1) DE69619141T2 (de)
PL (1) PL183661B1 (de)
WO (1) WO1997031009A1 (de)

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Also Published As

Publication number Publication date
DE69619141D1 (en) 2002-03-21
CZ262998A3 (cs) 1999-05-12
PL328639A1 (en) 1999-02-15
AU6178996A (en) 1997-09-10
PL183661B1 (pl) 2002-06-28
DE69619141T2 (de) 2002-09-26
EP0882059A1 (de) 1998-12-09
US5684143A (en) 1997-11-04
WO1997031009A1 (en) 1997-08-28
AU703509B2 (en) 1999-03-25
US5824793A (en) 1998-10-20
EP0882059B1 (de) 2002-02-06

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