ATE201983T1 - Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung - Google Patents

Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung

Info

Publication number
ATE201983T1
ATE201983T1 AT96906751T AT96906751T ATE201983T1 AT E201983 T1 ATE201983 T1 AT E201983T1 AT 96906751 T AT96906751 T AT 96906751T AT 96906751 T AT96906751 T AT 96906751T AT E201983 T1 ATE201983 T1 AT E201983T1
Authority
AT
Austria
Prior art keywords
microparticles
polypeptide
production
containing polypeptide
additives
Prior art date
Application number
AT96906751T
Other languages
German (de)
English (en)
Inventor
Hans Koll
Gerhard Winter
Thomas Kissel
Michael Morlock
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19513659A external-priority patent/DE19513659A1/de
Priority claimed from DE1995142837 external-priority patent/DE19542837A1/de
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Application granted granted Critical
Publication of ATE201983T1 publication Critical patent/ATE201983T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96906751T 1995-03-10 1996-03-07 Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung ATE201983T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19508612 1995-03-10
DE19513659A DE19513659A1 (de) 1995-03-10 1995-04-11 Polypeptid-enthaltende pharmazeutische Darreichungsformen in Form von Mikropartikeln und Verfahren zu deren Herstellung
DE1995142837 DE19542837A1 (de) 1995-11-17 1995-11-17 Polypeptid-enthaltende pharmazeutische Darreichungsformen in Form von Mikropartikeln und Verfahren zu deren Herstellung
PCT/EP1996/000980 WO1996028143A1 (de) 1995-03-10 1996-03-07 Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ATE201983T1 true ATE201983T1 (de) 2001-06-15

Family

ID=27214925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96906751T ATE201983T1 (de) 1995-03-10 1996-03-07 Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung

Country Status (11)

Country Link
US (1) US6346274B1 (da)
EP (1) EP0814778B1 (da)
JP (1) JP4979843B2 (da)
AT (1) ATE201983T1 (da)
AU (1) AU5004196A (da)
CA (1) CA2214889C (da)
DK (1) DK0814778T3 (da)
ES (1) ES2159726T3 (da)
GR (1) GR3036525T3 (da)
PT (1) PT814778E (da)
WO (1) WO1996028143A1 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59607089D1 (de) * 1995-03-10 2001-07-19 Roche Diagnostics Gmbh Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung
TWI240627B (en) * 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
KR100274842B1 (ko) * 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
DE10024451A1 (de) * 2000-05-18 2001-11-29 Asta Medica Ag Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
AU2001264706A1 (en) * 2000-05-19 2001-12-03 Battelle Memorial Institute Controlled release of materials from polymer matrices
FR2809309B1 (fr) * 2000-05-23 2004-06-11 Mainelab Microspheres a liberation prolongee pour administration injectable
KR100376083B1 (ko) * 2000-07-01 2003-03-15 주식회사 태평양 친수성 또는 염의 형태로 된 약물을 함유하는 서방형생체삽입용 생분해성 고분자 매트릭스
FR2811227A1 (fr) * 2000-07-07 2002-01-11 Philippe Maincent Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs
US8257744B2 (en) 2000-07-07 2012-09-04 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
US6967028B2 (en) 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
WO2002094324A1 (en) * 2001-05-18 2002-11-28 Institute Of Materials Research & Engineering Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
CN1537018A (zh) * 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
US20040146561A1 (en) * 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
WO2003041689A1 (en) 2001-11-12 2003-05-22 Alkermes Controlled Therapeutics, Inc. Biocompatible polymer blends and uses thereof
KR100449893B1 (ko) * 2001-12-10 2004-09-22 한국과학기술원 폴리에틸렌글리콜을 포함하는 생분해성 고분자를 이용한제자리 임플란트 조성물
DE10206517A1 (de) * 2002-02-16 2003-09-04 Stoess & Co Gelatine Depotarzneimittel, Trägermaterialien für Depotarzneimittel und Verfahren zu deren Herstellung
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
DK1532985T3 (da) * 2002-06-25 2016-12-05 Takeda Pharmaceuticals Co Fremgangsmåde til fremstilling af en sammensætning med langvarig frigivelse
ES2601143T3 (es) * 2002-07-19 2017-02-14 Omeros Corporation Copolímeros tribloque biodegradables, métodos de síntesis de los mismos, e hidrogeles y biomateriales preparados a partir de los mismos
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
EP1559440B1 (en) * 2002-10-29 2015-09-23 Toray Industries, Inc. Vascular embolization meterial
WO2004050683A2 (en) * 2002-12-02 2004-06-17 Abgenix, Inc. Antibodies directed to tumor necrosis factor and uses thereof
DK1610822T4 (da) * 2003-04-02 2019-01-14 Ares Trading Sa Flydende farmaceutiske FSH- og LH-formuleringer sammen med et ikke-ionisk overfladeaktivt stof
WO2005000222A2 (en) * 2003-05-30 2005-01-06 Amylin Pharmaceuticals, Inc. Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins
PT1639011E (pt) 2003-06-30 2009-01-20 Domantis Ltd Anticorpos (dab) de domínio único peguilados
ES2232287B1 (es) * 2003-07-04 2006-11-01 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de derivados polioxietilenados.
CA2819769C (en) * 2003-07-18 2016-06-28 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
WO2005110369A2 (en) * 2004-04-30 2005-11-24 American Pharmaceutical Partners, Inc. Sustained-release microspheres and methods of making and using same
US20090069226A1 (en) * 2004-05-28 2009-03-12 Amylin Pharmaceuticals, Inc. Transmucosal delivery of peptides and proteins
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
FI3660073T3 (fi) 2007-02-15 2023-09-11 Tolmar International Ltd Matalan purskeen poly(laktidi-ko-glykolidi)
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
EP2074988B1 (en) 2007-12-28 2018-03-14 Industrial Technology Research Institute Sustained release composition and manufacturing method thereof
US9161943B2 (en) 2007-12-31 2015-10-20 Industrial Technology Research Institute Sustained release composition and manufacturing method thereof
WO2010005725A2 (en) 2008-06-16 2010-01-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
US8613951B2 (en) * 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
ES2765240T3 (es) 2008-06-16 2020-06-08 Pfizer Nanopartículas poliméricas cargadas de fármaco y procedimientos de fabricación y uso de las mismas
PL2700651T3 (pl) 2008-07-18 2019-09-30 Bristol-Myers Squibb Company Kompozycje jednowartościowe dla wiązania cd28 i sposoby stosowania
WO2010068866A2 (en) 2008-12-12 2010-06-17 Bind Biosciences Therapeutic particles suitable for parenteral administration and methods of making and using same
JP2012512175A (ja) 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
EP2400987B1 (en) * 2009-02-25 2014-09-03 Supratek Pharma, Inc. Bendamustine cyclopolysaccharide compositions
EP2509634B1 (en) 2009-12-11 2019-03-06 Pfizer Inc Stable formulations for lyophilizing therapeutic particles
JP5965844B2 (ja) 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
CN102740895B (zh) * 2009-12-23 2016-02-24 伊利诺伊大学董事会 纳米轭合物以及纳米轭合物配制品
GB201009037D0 (en) 2010-05-28 2010-07-14 Univ Surrey Compositions and methods for treating disorders associated with atherosclerotic plaques
KR102302069B1 (ko) 2010-11-10 2021-09-14 인리젠 장기 확대를 위한 주사가능 제제
TWI641396B (zh) 2011-09-23 2018-11-21 Bvw控股公司 醫療共聚物
EP2895156B1 (en) 2012-09-17 2019-05-08 Pfizer Inc. Process for preparing therapeutic nanoparticles
KR20240096798A (ko) 2012-10-24 2024-06-26 인리젠 신장 세포 모집단 및 이의 용도
WO2014120916A1 (en) 2013-02-01 2014-08-07 Bristol-Myers Squibb Company Pegylated domain antibodies monovalent for cd28 binding and methods of use
AU2014236938B2 (en) * 2013-03-14 2018-12-20 Allergan, Inc. Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process
TWI693937B (zh) 2014-03-14 2020-05-21 美商輝瑞大藥廠 包含治療劑之治療性奈米顆粒及其製造及使用方法
US20180264119A1 (en) * 2015-09-16 2018-09-20 Shimadzu Corporation Nanoparticles and method for producing same
WO2019013255A1 (ja) * 2017-07-11 2019-01-17 学校法人東京薬科大学 核酸送達用組成物及び核酸含有組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5690954A (en) * 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
US5594091A (en) * 1994-02-21 1997-01-14 Takeda Chemical Industries, Ltd. Matrix for sustained-release preparation

Also Published As

Publication number Publication date
JP4979843B2 (ja) 2012-07-18
EP0814778A1 (de) 1998-01-07
US6346274B1 (en) 2002-02-12
PT814778E (pt) 2001-11-30
EP0814778B1 (de) 2001-06-13
GR3036525T3 (en) 2001-12-31
JPH11501642A (ja) 1999-02-09
AU5004196A (en) 1996-10-02
CA2214889A1 (en) 1996-09-19
CA2214889C (en) 2005-05-24
ES2159726T3 (es) 2001-10-16
DK0814778T3 (da) 2001-09-17
WO1996028143A1 (de) 1996-09-19

Similar Documents

Publication Publication Date Title
ATE201983T1 (de) Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung
DK1137400T3 (da) Præparater indeholdende et peptid og polymælkesyre-glycolsyre egnet til fremstilling af subkutane implantater med en forlænget frigivelsesperiode
ATE431236T1 (de) Verfahren zum herstellen von festen wirkstoffhaltigen formen
ATE405251T1 (de) Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung
EP1025840A3 (en) Oral drug compositions and methods
JP2021073295A (ja) 生分解性薬物送達組成物
ES2145298T3 (es) Preparacion de microesferas, de peliculas y de revestimientos a partir de proteinas.
ATE216699T1 (de) Ein itraconazol mit einer verbesserten löslichkeit, ein verfahren zu seiner herstellung und eine pharmazeutische zusammensetzung zur oralen verabreichung, die dieses enthält
DE59607548D1 (de) Verfahren zur herstellung von morphologisch einheitlichen mikrokapseln sowie nach diesem verfahren hergestellte mikrokapseln
ATE335011T1 (de) Verfahren zur vernetzung von hyaluronsäure mit polymeren
WO2004032862A3 (en) Cyclodextrin-based materials, compositions and uses related thereto
PT94842A (pt) Processo para a preparacao de uma composicao farmaceutica sob a forma de microparticulas de um copolimero de acido lactico e glicolico e incorporando como substancia activa um pamoato, tanato, estearato ou palmitato de um peptido natural ou sintetico
ATE342306T1 (de) Polymere zusammensetzung zur lösung von schwer wasserlöslichen medikamenten und verfahren zu deren herstellung
ATE141788T1 (de) Mikrosphäre enthaltende pharmazeutische zusammensetzung mit kontrollierter freigabe und verfahren zur herstellung
BR9915198A (pt) Composto dds e método para medição do mesmo
ATE298578T1 (de) Lipid a-analoge enthaltende injektionen und verfahren zu deren herstellung
ATE263225T1 (de) Verfahren zur kontinuierlichen herstellung und beschichtung von selbstklebemassen auf basis von polyisobutylen mit mindestens einem pharmazeutischen wirkstoff
DE68927669D1 (de) Verfahren zur herstellung von in lösungsmitteln verdünnbaren mikroträgern
DE69527711D1 (de) Verfahren und apparat zur herstellung von schnelllöslichen dosierungseinheiten und daraus erhältliches produkt
FR2768341B1 (fr) Composition pharmaceutique placebo lyophilisable destinee a imiter un medicament, notamment a base de proteines ou de polypeptides
BR9809103A (pt) Forma farmacêutica estável de administração para peptìdeos, proteìnas e ácidos nucléicos
Lu et al. In vitro release profiles of eristostatin from biodegradable polymeric microspheres: protein aggregation problem
EP0336353A3 (de) Verfahren zur kinetischen Bestimmung von Faktor XIII
ES2153648T3 (es) Polimeros con estado fisico y bioerosionabilidad controlados.
EP0923943A4 (en) MICELLAR AQUEOUS COMPOSITION AND METHOD FOR SOLVING A HYDROPHOBIC MEDICINAL PRODUCT