ATE199908T1 - Verfahren zur kupplung von polysacchariden und proteinen - Google Patents

Verfahren zur kupplung von polysacchariden und proteinen

Info

Publication number
ATE199908T1
ATE199908T1 AT96203556T AT96203556T ATE199908T1 AT E199908 T1 ATE199908 T1 AT E199908T1 AT 96203556 T AT96203556 T AT 96203556T AT 96203556 T AT96203556 T AT 96203556T AT E199908 T1 ATE199908 T1 AT E199908T1
Authority
AT
Austria
Prior art keywords
chr
hydrogen
carbamoyl
integer
amino
Prior art date
Application number
AT96203556T
Other languages
English (en)
Inventor
Peter Hoogerhout
Original Assignee
Nederlanden Staat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlanden Staat filed Critical Nederlanden Staat
Application granted granted Critical
Publication of ATE199908T1 publication Critical patent/ATE199908T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AT96203556T 1996-12-16 1996-12-16 Verfahren zur kupplung von polysacchariden und proteinen ATE199908T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96203556A EP0848011B1 (de) 1996-12-16 1996-12-16 Verfahren zur Kupplung von Polysacchariden und Proteinen

Publications (1)

Publication Number Publication Date
ATE199908T1 true ATE199908T1 (de) 2001-04-15

Family

ID=8224703

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96203556T ATE199908T1 (de) 1996-12-16 1996-12-16 Verfahren zur kupplung von polysacchariden und proteinen

Country Status (12)

Country Link
US (1) US6361777B1 (de)
EP (1) EP0848011B1 (de)
JP (1) JP4619459B2 (de)
AT (1) ATE199908T1 (de)
AU (1) AU5347898A (de)
CA (1) CA2274852C (de)
DE (1) DE69612205T2 (de)
DK (1) DK0848011T3 (de)
ES (1) ES2156611T3 (de)
GR (1) GR3035918T3 (de)
PT (1) PT848011E (de)
WO (1) WO1998027107A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248334B1 (en) * 1997-01-08 2001-06-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
NZ537735A (en) * 2002-07-03 2006-08-31 Pericor Science Inc Compositions of hyaluronic acid and methods of use
EP2479184A3 (de) 2003-12-17 2013-09-04 Janssen Alzheimer Immunotherapy Beta-Immunogen-Peptidträgerkonjugate und Herstellungsverfahren dafür
SG149013A1 (en) 2003-12-17 2009-01-29 Wyeth Corp Immunogenic peptide carrier conjugates and methods of producing same
CN102239001B (zh) 2008-12-03 2014-03-12 株式会社钟化 含有甲酰基的多孔性载体、使用该多孔性载体的吸附体以及它们的制造方法
DK2924053T3 (da) * 2012-11-22 2020-12-14 Glytech Inc Glycosyleret linker, forbindelse, der indeholder glycosyleret linker-del og fysiologisk aktiv stofdel eller salt deraf, og fremgangsmåder til fremstilling af forbindelsen eller saltet deraf
JP6219308B2 (ja) 2012-11-30 2017-10-25 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカーと生理活性物質とを含む化合物またはその塩、及びそれらの製造方法
JP2017505792A (ja) * 2014-02-14 2017-02-23 ファイザー・インク 免疫原性糖タンパク質コンジュゲート
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549051B1 (fr) 1983-06-22 1986-05-16 Centre Nat Rech Scient Nouveaux agents radioprotecteurs ayant une structure amino-thioalkyle et procede pour leur preparation
US4762713A (en) 1983-07-05 1988-08-09 The University Of Rochester Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers
EP0326111A3 (de) * 1988-01-29 1989-12-27 New York Blood Center, Inc. Peptid-Derivate, immunogenisch gemacht bei Verabreichung zusammen mit Alaun als Zusatzmittel
US5738855A (en) * 1994-10-17 1998-04-14 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide

Also Published As

Publication number Publication date
WO1998027107A1 (en) 1998-06-25
EP0848011B1 (de) 2001-03-21
PT848011E (pt) 2001-08-30
CA2274852C (en) 2008-06-17
DK0848011T3 (da) 2001-07-16
JP2001509144A (ja) 2001-07-10
DE69612205D1 (de) 2001-04-26
GR3035918T3 (en) 2001-08-31
EP0848011A1 (de) 1998-06-17
ES2156611T3 (es) 2001-07-01
CA2274852A1 (en) 1998-06-25
US6361777B1 (en) 2002-03-26
AU5347898A (en) 1998-07-15
WO1998027107A8 (en) 2000-01-20
JP4619459B2 (ja) 2011-01-26
DE69612205T2 (de) 2001-08-30

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Legal Events

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UEP Publication of translation of european patent specification