ATE199153T1 - Verfahren zur herstellung von galanthamin und deren derivaten - Google Patents
Verfahren zur herstellung von galanthamin und deren derivatenInfo
- Publication number
- ATE199153T1 ATE199153T1 AT96931170T AT96931170T ATE199153T1 AT E199153 T1 ATE199153 T1 AT E199153T1 AT 96931170 T AT96931170 T AT 96931170T AT 96931170 T AT96931170 T AT 96931170T AT E199153 T1 ATE199153 T1 AT E199153T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- crushed
- compound
- bulbs
- galanthamine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title 2
- HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 title 1
- LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 title 1
- 229960003980 galantamine Drugs 0.000 title 1
- BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 title 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title 1
- IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000015256 Chionanthus virginicus Nutrition 0.000 abstract 1
- 241000234271 Galanthus Species 0.000 abstract 1
- 241000234479 Narcissus Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000000419 plant extract Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9519268.8A GB9519268D0 (en) | 1995-09-21 | 1995-09-21 | Preparation of alkaloids |
| PCT/GB1996/002335 WO1997011078A1 (en) | 1995-09-21 | 1996-09-23 | Process for the preparation of galanthamine and its derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199153T1 true ATE199153T1 (de) | 2001-02-15 |
Family
ID=10781039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96931170T ATE199153T1 (de) | 1995-09-21 | 1996-09-23 | Verfahren zur herstellung von galanthamin und deren derivaten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6184004B1 (de) |
| EP (1) | EP0853624B1 (de) |
| AT (1) | ATE199153T1 (de) |
| AU (1) | AU710980B2 (de) |
| CA (1) | CA2230824C (de) |
| DE (1) | DE69611796T2 (de) |
| DK (1) | DK0853624T3 (de) |
| ES (1) | ES2155200T3 (de) |
| GB (1) | GB9519268D0 (de) |
| GR (1) | GR3035752T3 (de) |
| PT (1) | PT853624E (de) |
| WO (1) | WO1997011078A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| JP2003529602A (ja) | 2000-03-31 | 2003-10-07 | ザノヒェミア・ファルマツォイティカ・アーゲー | ガランタミンの新規誘導体および類似体 |
| JP4029960B2 (ja) | 2001-10-05 | 2008-01-09 | 独立行政法人理化学研究所 | アブシジン酸生合成阻害剤 |
| US20050142193A1 (en) * | 2003-12-31 | 2005-06-30 | Lijuan Tang | Galantamine formulations |
| CA2551946A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Immediate, controlled and sustained release formulations of galantamine |
| DE602006016441D1 (de) * | 2005-05-13 | 2010-10-07 | Alza Corp | Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss |
| WO2007035941A2 (en) * | 2005-09-23 | 2007-03-29 | Alza Corporation | Transdermal galantamine delivery system |
| AT504663B1 (de) * | 2007-02-22 | 2008-07-15 | Sanochemia Pharmazeutika Ag | Verfahren zum herstellen von hochreinen 4a,5,9,10,11,12,-hexahydro-6h-benzofuro(3a,3,2- f)(2) benzazepinen sowie dessen derivaten |
| CN104592243B (zh) * | 2014-12-19 | 2016-08-24 | 北京大学 | 加兰他敏和力克拉敏的不对称合成方法 |
| BG67337B1 (bg) | 2018-05-23 | 2021-06-15 | Софарма Ад | Метод за получаване на пречистен галантамин хидробромид |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4290862A (en) * | 1979-11-14 | 1981-09-22 | Edinen Centar P Chimia | Method for the preparation of narwedine-type enones |
| US5336675A (en) * | 1991-05-14 | 1994-08-09 | Ernir Snorrason | Method of treating mania in humans |
| US5428159A (en) * | 1994-04-08 | 1995-06-27 | Ciba-Geigy Corporation | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine |
-
1995
- 1995-09-21 GB GBGB9519268.8A patent/GB9519268D0/en active Pending
-
1996
- 1996-09-23 WO PCT/GB1996/002335 patent/WO1997011078A1/en not_active Ceased
- 1996-09-23 DE DE69611796T patent/DE69611796T2/de not_active Expired - Lifetime
- 1996-09-23 AU AU69965/96A patent/AU710980B2/en not_active Expired
- 1996-09-23 DK DK96931170T patent/DK0853624T3/da active
- 1996-09-23 US US09/043,598 patent/US6184004B1/en not_active Expired - Lifetime
- 1996-09-23 AT AT96931170T patent/ATE199153T1/de active
- 1996-09-23 PT PT96931170T patent/PT853624E/pt unknown
- 1996-09-23 CA CA002230824A patent/CA2230824C/en not_active Expired - Lifetime
- 1996-09-23 ES ES96931170T patent/ES2155200T3/es not_active Expired - Lifetime
- 1996-09-23 EP EP96931170A patent/EP0853624B1/de not_active Expired - Lifetime
-
2001
- 2001-04-12 GR GR20010400603T patent/GR3035752T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9519268D0 (en) | 1995-11-22 |
| EP0853624B1 (de) | 2001-02-14 |
| DE69611796D1 (de) | 2001-03-22 |
| AU6996596A (en) | 1997-04-09 |
| CA2230824C (en) | 2009-09-15 |
| GR3035752T3 (en) | 2001-07-31 |
| US6184004B1 (en) | 2001-02-06 |
| DE69611796T2 (de) | 2001-10-11 |
| WO1997011078A1 (en) | 1997-03-27 |
| ES2155200T3 (es) | 2001-05-01 |
| PT853624E (pt) | 2001-06-29 |
| EP0853624A1 (de) | 1998-07-22 |
| CA2230824A1 (en) | 1997-03-27 |
| DK0853624T3 (da) | 2001-05-07 |
| AU710980B2 (en) | 1999-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |