ATE19627T1 - Substituierte pyrimidin-2-one, ihre salze, verfahren zu deren herstellung und diese enthaltende zusammensetzungen. - Google Patents
Substituierte pyrimidin-2-one, ihre salze, verfahren zu deren herstellung und diese enthaltende zusammensetzungen.Info
- Publication number
- ATE19627T1 ATE19627T1 AT81303254T AT81303254T ATE19627T1 AT E19627 T1 ATE19627 T1 AT E19627T1 AT 81303254 T AT81303254 T AT 81303254T AT 81303254 T AT81303254 T AT 81303254T AT E19627 T1 ATE19627 T1 AT E19627T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- compounds
- salts
- compositions containing
- susceptible
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000002159 abnormal effect Effects 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 238000003683 electrophilic halogenation reaction Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 230000031864 metaphase Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8023063 | 1980-07-15 | ||
| EP81303254A EP0044704B1 (de) | 1980-07-15 | 1981-07-15 | Substituierte Pyrimidin-2-one, ihre Salze, Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE19627T1 true ATE19627T1 (de) | 1986-05-15 |
Family
ID=10514771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT81303254T ATE19627T1 (de) | 1980-07-15 | 1981-07-15 | Substituierte pyrimidin-2-one, ihre salze, verfahren zu deren herstellung und diese enthaltende zusammensetzungen. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4636509A (de) |
| EP (1) | EP0044704B1 (de) |
| JP (1) | JPS5740471A (de) |
| AT (1) | ATE19627T1 (de) |
| AU (1) | AU7300381A (de) |
| CA (1) | CA1160226A (de) |
| DE (1) | DE3174554D1 (de) |
| DK (1) | DK315281A (de) |
| ES (2) | ES503984A0 (de) |
| NO (1) | NO812431L (de) |
| NZ (1) | NZ197714A (de) |
| ZA (1) | ZA814845B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1179883A (en) * | 1982-02-24 | 1983-09-01 | Nyegaard & Co. A/S | Pyrimidin-z-ones |
| GB2135992B (en) * | 1983-01-11 | 1986-09-24 | Nyegaard & Co As | Substituted pyrimidines and processes for their preparation |
| GB8420610D0 (en) * | 1984-08-14 | 1984-09-19 | Glaxo Group Ltd | Chemical compounds |
| US4849426A (en) * | 1987-05-15 | 1989-07-18 | Pearlman Dale L | Method for treating actinic keratosis with cytotoxic agents |
| US4820711A (en) * | 1987-05-15 | 1989-04-11 | Pearlman Dale L | Method for treating actinic keratosis with cytotoxic agents |
| US4853388A (en) * | 1987-05-15 | 1989-08-01 | Pearlman Dale L | Method for treating psoriasis with cytotoxic agents |
| US4855466A (en) * | 1987-12-28 | 1989-08-08 | E. R. Squibb & Sons, Inc. | Purinyl cyclobutanes |
| ES2293638T3 (es) * | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| CN1964950A (zh) * | 2004-06-04 | 2007-05-16 | 安斯泰来制药有限公司 | 丙烷－1,3－二酮衍生物或其盐 |
| EP1864976B1 (de) * | 2005-03-31 | 2012-10-10 | Astellas Pharma Inc. | Propan-1,3-dionderivat oder salz davon |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1561290A (en) * | 1975-10-16 | 1980-02-20 | Nyegaard & Co As | Pyrimid - 2 - ones |
| ES498337A0 (es) * | 1980-01-07 | 1982-06-01 | Nyegaard & Co As | Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas |
| GB2080301B (en) * | 1980-07-15 | 1984-04-18 | Glaxo Group Ltd | Substituted pyrimidin-2-ones the salts thereof processes for their preparation and pharmaceutical compositions containing them |
| GB2080300B (en) * | 1980-07-15 | 1984-04-26 | Glaxo Group Ltd | Substituted pyrimidin-2-ones the salts thereof processes for their preparation and pharmaceutical compositions containing them |
-
1981
- 1981-07-14 NZ NZ197714A patent/NZ197714A/en unknown
- 1981-07-14 CA CA000381712A patent/CA1160226A/en not_active Expired
- 1981-07-15 DE DE8181303254T patent/DE3174554D1/de not_active Expired
- 1981-07-15 EP EP81303254A patent/EP0044704B1/de not_active Expired
- 1981-07-15 ES ES503984A patent/ES503984A0/es active Granted
- 1981-07-15 AT AT81303254T patent/ATE19627T1/de not_active IP Right Cessation
- 1981-07-15 JP JP56110634A patent/JPS5740471A/ja active Pending
- 1981-07-15 AU AU73003/81A patent/AU7300381A/en not_active Abandoned
- 1981-07-15 ZA ZA814845A patent/ZA814845B/xx unknown
- 1981-07-15 NO NO812431A patent/NO812431L/no unknown
- 1981-07-15 DK DK315281A patent/DK315281A/da not_active Application Discontinuation
-
1982
- 1982-06-16 ES ES513177A patent/ES8307758A1/es not_active Expired
-
1983
- 1983-05-27 US US06/498,723 patent/US4636509A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0044704B1 (de) | 1986-05-07 |
| JPS5740471A (en) | 1982-03-06 |
| AU7300381A (en) | 1982-01-21 |
| ES8301473A1 (es) | 1982-12-01 |
| NZ197714A (en) | 1984-11-09 |
| EP0044704A1 (de) | 1982-01-27 |
| ZA814845B (en) | 1983-02-23 |
| ES513177A0 (es) | 1983-07-01 |
| DK315281A (da) | 1982-01-16 |
| US4636509A (en) | 1987-01-13 |
| DE3174554D1 (en) | 1986-06-12 |
| ES503984A0 (es) | 1982-12-01 |
| ES8307758A1 (es) | 1983-07-01 |
| NO812431L (no) | 1982-01-18 |
| CA1160226A (en) | 1984-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |