ATE191221T1 - Steroid-sulfatase hemmende verbindungen - Google Patents

Steroid-sulfatase hemmende verbindungen

Info

Publication number
ATE191221T1
ATE191221T1 AT92918634T AT92918634T ATE191221T1 AT E191221 T1 ATE191221 T1 AT E191221T1 AT 92918634 T AT92918634 T AT 92918634T AT 92918634 T AT92918634 T AT 92918634T AT E191221 T1 ATE191221 T1 AT E191221T1
Authority
AT
Austria
Prior art keywords
steroid sulfatase
inhibiting compounds
sulfatase inhibiting
steroid
compounds
Prior art date
Application number
AT92918634T
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of ATE191221T1 publication Critical patent/ATE191221T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92918634T 1991-08-29 1992-08-28 Steroid-sulfatase hemmende verbindungen ATE191221T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919118465A GB9118465D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors
PCT/GB1992/001586 WO1993005063A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
ATE191221T1 true ATE191221T1 (de) 2000-04-15

Family

ID=10700597

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92918634T ATE191221T1 (de) 1991-08-29 1992-08-28 Steroid-sulfatase hemmende verbindungen

Country Status (8)

Country Link
US (3) US5604215A (de)
EP (1) EP0602123B1 (de)
JP (2) JP3583776B2 (de)
AT (1) ATE191221T1 (de)
AU (1) AU2494992A (de)
DE (1) DE69230857T2 (de)
GB (1) GB9118465D0 (de)
WO (1) WO1993005063A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US5449712A (en) * 1993-01-13 1995-09-12 Thoro System Products, Inc. Organosilicon emulsions for rendering porous substrates water repellent
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
FR2730734B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Nouveaux composes manifestant des proprietes inhibitrices de farnesyl transferase et microorganisme du genre chrysosporium susceptible d'etre utilise pour les preparer
AU7013296A (en) * 1995-08-30 1997-03-19 Eli Lilly And Company N-butylsulfonate esters of estrogens
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US6288050B1 (en) 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6489369B1 (en) 1999-02-03 2002-12-03 Supergen, Inc. Phosphocholine surfactants and their use
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
JP5042411B2 (ja) 1999-04-30 2012-10-03 ステリックス リミテッド 抗腫瘍剤としてのエストロン誘導体の使用
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
DK1237902T3 (da) 1999-12-13 2006-03-06 Sterix Ltd Halogenerede sulphamat-, fosfonat-, thiofosfonat-, sulfonat- og sulfonamidforbindelser som hæmmere af steroid sulfatase
US7335650B2 (en) * 2000-01-14 2008-02-26 Sterix Limited Composition
AU2001248849A1 (en) * 2000-04-24 2001-11-07 Kyowa Hakko Kogyo Co. Ltd. Estra-1,3,5(10)-triene derivatives
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
WO2005020928A2 (en) 2003-08-29 2005-03-10 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
EP1889198B1 (de) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatiksystem
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
US9670244B2 (en) 2006-02-27 2017-06-06 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
GB0604142D0 (en) 2006-03-01 2006-04-12 Sterix Ltd Compound
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
CA2698814A1 (en) 2007-09-17 2009-03-26 Preglem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women
CN101951915A (zh) 2007-12-03 2011-01-19 加利福尼亚大学董事会 用于刺猬蛋白信号、骨诱导、抗脂肪形成和wnt信号的激活的氧固醇
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (de) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermale freisetzungszusammensetzung mit wirkstoff-calciumphosphat-partikelkomplexen und anwendungsverfahren
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
EP2847206A4 (de) 2012-05-07 2016-01-20 Univ California Oxysterol-analogon oxy133 zur induktion von osteogenese und hedgehog-signalisierung sowie zur adipogenesehemmung
CN105263500A (zh) 2013-05-02 2016-01-20 加利福尼亚大学董事会 骨选择性成骨性氧固醇-骨靶向剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE120016C (de) *
DE201143C (de) *
FR2133484A2 (en) * 1969-04-29 1972-12-01 Jenapharm Veb 3-17 and 21-sulphonyloxy-steroids - with androgenic anabolic progestogenic and oestrogen activity of long duration
DK127417B (da) * 1969-11-21 1973-11-05 Glaxo Lab Ltd Fremgangsmåde til fremstilling af 9α- og/eller 9β-hydroxy-11β-nitrooxysteroider med aromatisk A-ring.
BE779841R (en) * 1972-02-25 1972-06-16 Jenapharm Veb Sulphonyloxy-13-beta-ethyl-gonanes - as oestrogenic-genic anti-fecundity and anti-lipaemic agents
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DD120016A2 (de) * 1975-02-17 1976-05-20
GB1527161A (en) * 1976-02-19 1978-10-04 Leo A Enol esters of steroids
DD201143B1 (de) * 1981-11-17 1986-12-17 Jenapharm Veb Verfahren zur herstellung von 9,11-tritiummarkierten gonatriensulfonaten
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
US5177064A (en) * 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives

Also Published As

Publication number Publication date
JP3786855B2 (ja) 2006-06-14
WO1993005063A1 (en) 1993-03-18
JP3583776B2 (ja) 2004-11-04
DE69230857T2 (de) 2000-11-02
JPH07501514A (ja) 1995-02-16
US5604215A (en) 1997-02-18
EP0602123A1 (de) 1994-06-22
JP2002145891A (ja) 2002-05-22
EP0602123B1 (de) 2000-03-29
US6017904A (en) 2000-01-25
DE69230857D1 (de) 2000-05-04
US5861390A (en) 1999-01-19
AU2494992A (en) 1993-04-05
GB9118465D0 (en) 1991-10-16

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties