ATE186464T1 - Zusammensetzungen und verfahren zur regulierung der rns-aktivität durch abänderung der rns ''5'- cap-struktur'' - Google Patents
Zusammensetzungen und verfahren zur regulierung der rns-aktivität durch abänderung der rns ''5'- cap-struktur''Info
- Publication number
- ATE186464T1 ATE186464T1 AT91911934T AT91911934T ATE186464T1 AT E186464 T1 ATE186464 T1 AT E186464T1 AT 91911934 T AT91911934 T AT 91911934T AT 91911934 T AT91911934 T AT 91911934T AT E186464 T1 ATE186464 T1 AT E186464T1
- Authority
- AT
- Austria
- Prior art keywords
- rns
- cap structure
- methods
- regulating
- altering
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52759990A | 1990-05-23 | 1990-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE186464T1 true ATE186464T1 (de) | 1999-11-15 |
Family
ID=24102143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91911934T ATE186464T1 (de) | 1990-05-23 | 1991-05-22 | Zusammensetzungen und verfahren zur regulierung der rns-aktivität durch abänderung der rns ''5'- cap-struktur'' |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0531447B1 (de) |
| JP (1) | JPH06500075A (de) |
| KR (1) | KR960004931B1 (de) |
| AT (1) | ATE186464T1 (de) |
| AU (1) | AU649458B2 (de) |
| BR (1) | BR9106486A (de) |
| CA (1) | CA2083377C (de) |
| DE (1) | DE69131773T2 (de) |
| DK (1) | DK0531447T3 (de) |
| ES (1) | ES2139578T3 (de) |
| FI (1) | FI925210A (de) |
| GR (1) | GR3032457T3 (de) |
| HU (1) | HUT63568A (de) |
| NO (1) | NO924309L (de) |
| WO (1) | WO1991017755A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789573A (en) * | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
| EP0691853B1 (de) * | 1993-04-01 | 2002-06-05 | Isis Pharmaceuticals, Inc. | ANTISENSE OLIGONNUKLEOTIDE DIE MIT DER mRNA CAP AKTIVITÄT INTERFERIEREN UND DIE TRANSLATION INHIBIEREN |
| IL114235A0 (en) * | 1994-07-14 | 1995-10-31 | Schering Ag | Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same |
| US6380169B1 (en) * | 1994-08-31 | 2002-04-30 | Isis Pharmaceuticals, Inc. | Metal complex containing oligonucleoside cleavage compounds and therapies |
| US5962271A (en) * | 1996-01-03 | 1999-10-05 | Cloutech Laboratories, Inc. | Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end |
| EP1261734A1 (de) * | 2000-02-25 | 2002-12-04 | Montclair Group | GENOMISCHE ANALYSE VON tRNA-GENSETS |
| EP2370451B1 (de) | 2008-12-02 | 2016-11-16 | Wave Life Sciences Japan, Inc. | Verfahren zur synthese von am phosphoratom modifizierten nukleinsäuren |
| AU2010270714B2 (en) | 2009-07-06 | 2015-08-13 | Wave Life Sciences Ltd. | Novel nucleic acid prodrugs and methods use thereof |
| EP2620428B1 (de) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetrische hilfsgruppe |
| JP6128529B2 (ja) | 2011-07-19 | 2017-05-17 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | 官能化核酸の合成のための方法 |
| US9617547B2 (en) | 2012-07-13 | 2017-04-11 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| CN104661664B (zh) | 2012-07-13 | 2020-07-03 | 波涛生命科学有限公司 | 手性控制 |
| EP2872485B1 (de) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetrische hilfsgruppe |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| CA2936712A1 (en) | 2014-01-16 | 2015-07-23 | Meena | Chiral design |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
| HUT63170A (en) * | 1990-01-11 | 1993-07-28 | Isis Pharmaceuticals Inc | Process and composition for detecting and modifying rna activity and gene expression |
-
1991
- 1991-05-22 ES ES91911934T patent/ES2139578T3/es not_active Expired - Lifetime
- 1991-05-22 HU HU923659A patent/HUT63568A/hu unknown
- 1991-05-22 CA CA002083377A patent/CA2083377C/en not_active Expired - Lifetime
- 1991-05-22 JP JP3511198A patent/JPH06500075A/ja active Pending
- 1991-05-22 AU AU80802/91A patent/AU649458B2/en not_active Expired
- 1991-05-22 DK DK91911934T patent/DK0531447T3/da active
- 1991-05-22 EP EP91911934A patent/EP0531447B1/de not_active Expired - Lifetime
- 1991-05-22 WO PCT/US1991/003606 patent/WO1991017755A1/en active IP Right Grant
- 1991-05-22 BR BR919106486A patent/BR9106486A/pt not_active Application Discontinuation
- 1991-05-22 AT AT91911934T patent/ATE186464T1/de not_active IP Right Cessation
- 1991-05-22 DE DE69131773T patent/DE69131773T2/de not_active Expired - Fee Related
- 1991-05-22 KR KR1019920702920A patent/KR960004931B1/ko not_active IP Right Cessation
-
1992
- 1992-11-09 NO NO92924309A patent/NO924309L/no unknown
- 1992-11-17 FI FI925210A patent/FI925210A/fi not_active Application Discontinuation
-
2000
- 2000-01-25 GR GR20000400151T patent/GR3032457T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2083377C (en) | 2002-11-26 |
| KR930700118A (ko) | 1993-03-13 |
| EP0531447A4 (en) | 1993-08-11 |
| EP0531447A1 (de) | 1993-03-17 |
| HU9203659D0 (en) | 1993-04-28 |
| DE69131773D1 (de) | 1999-12-16 |
| AU8080291A (en) | 1991-12-10 |
| FI925210A0 (fi) | 1992-11-17 |
| BR9106486A (pt) | 1993-05-25 |
| JPH06500075A (ja) | 1994-01-06 |
| NO924309D0 (no) | 1992-11-09 |
| AU649458B2 (en) | 1994-05-26 |
| KR960004931B1 (ko) | 1996-04-18 |
| ES2139578T3 (es) | 2000-02-16 |
| GR3032457T3 (en) | 2000-05-31 |
| HUT63568A (en) | 1993-09-28 |
| NO924309L (no) | 1992-11-09 |
| DK0531447T3 (da) | 2000-03-27 |
| EP0531447B1 (de) | 1999-11-10 |
| CA2083377A1 (en) | 1991-11-24 |
| FI925210A (fi) | 1992-11-17 |
| WO1991017755A1 (en) | 1991-11-28 |
| DE69131773T2 (de) | 2000-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |