DK0531447T3 - Præparater og fremgangsmåder til modulering af RNA-aktivitet ved modifikation af 5'-cap-strukturen af RNA - Google Patents

Præparater og fremgangsmåder til modulering af RNA-aktivitet ved modifikation af 5'-cap-strukturen af RNA

Info

Publication number
DK0531447T3
DK0531447T3 DK91911934T DK91911934T DK0531447T3 DK 0531447 T3 DK0531447 T3 DK 0531447T3 DK 91911934 T DK91911934 T DK 91911934T DK 91911934 T DK91911934 T DK 91911934T DK 0531447 T3 DK0531447 T3 DK 0531447T3
Authority
DK
Denmark
Prior art keywords
rna
cap structure
methods
modifying
compositions
Prior art date
Application number
DK91911934T
Other languages
English (en)
Inventor
Brenda F Baker
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DK0531447T3 publication Critical patent/DK0531447T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
DK91911934T 1990-05-23 1991-05-22 Præparater og fremgangsmåder til modulering af RNA-aktivitet ved modifikation af 5'-cap-strukturen af RNA DK0531447T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52759990A 1990-05-23 1990-05-23
PCT/US1991/003606 WO1991017755A1 (en) 1990-05-23 1991-05-22 Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna

Publications (1)

Publication Number Publication Date
DK0531447T3 true DK0531447T3 (da) 2000-03-27

Family

ID=24102143

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91911934T DK0531447T3 (da) 1990-05-23 1991-05-22 Præparater og fremgangsmåder til modulering af RNA-aktivitet ved modifikation af 5'-cap-strukturen af RNA

Country Status (15)

Country Link
EP (1) EP0531447B1 (da)
JP (1) JPH06500075A (da)
KR (1) KR960004931B1 (da)
AT (1) ATE186464T1 (da)
AU (1) AU649458B2 (da)
BR (1) BR9106486A (da)
CA (1) CA2083377C (da)
DE (1) DE69131773T2 (da)
DK (1) DK0531447T3 (da)
ES (1) ES2139578T3 (da)
FI (1) FI925210A (da)
GR (1) GR3032457T3 (da)
HU (1) HUT63568A (da)
NO (1) NO924309D0 (da)
WO (1) WO1991017755A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789573A (en) * 1990-08-14 1998-08-04 Isis Pharmaceuticals, Inc. Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
WO1994022488A1 (en) * 1993-04-01 1994-10-13 Isis Pharmaceuticals, Inc. ANTISENSE OLIGOS WHICH INTERFERE WITH mRNA CAP ACTIVITY AND INHIBIT TRANSLATION
IL114235A0 (en) * 1994-07-14 1995-10-31 Schering Ag Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same
US6380169B1 (en) * 1994-08-31 2002-04-30 Isis Pharmaceuticals, Inc. Metal complex containing oligonucleoside cleavage compounds and therapies
US5962271A (en) * 1996-01-03 1999-10-05 Cloutech Laboratories, Inc. Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
WO2001062981A1 (en) * 2000-02-25 2001-08-30 Montclair Group Platform for the discovery of the bacterial genes involved in rna modification
WO2010064146A2 (en) 2008-12-02 2010-06-10 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
IN2012DN00720A (da) 2009-07-06 2015-06-19 Ontorii Inc
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
SG11201500243WA (en) 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
PT2872485T (pt) 2012-07-13 2021-03-05 Wave Life Sciences Ltd Grupo auxiliar assimétrico
CA2878945A1 (en) 2012-07-13 2014-01-16 Wave Life Sciences Pte. Ltd. Chiral control
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
CN106068325B (zh) 2014-01-16 2021-07-09 波涛生命科学有限公司 手性设计

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
ATE271064T1 (de) * 1990-01-11 2004-07-15 Isis Pharmaceuticals Inc Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression

Also Published As

Publication number Publication date
EP0531447B1 (en) 1999-11-10
JPH06500075A (ja) 1994-01-06
HUT63568A (en) 1993-09-28
DE69131773D1 (de) 1999-12-16
KR960004931B1 (ko) 1996-04-18
AU649458B2 (en) 1994-05-26
ATE186464T1 (de) 1999-11-15
BR9106486A (pt) 1993-05-25
AU8080291A (en) 1991-12-10
CA2083377C (en) 2002-11-26
FI925210A0 (fi) 1992-11-17
NO924309L (no) 1992-11-09
FI925210A (fi) 1992-11-17
KR930700118A (ko) 1993-03-13
HU9203659D0 (en) 1993-04-28
DE69131773T2 (de) 2000-03-02
ES2139578T3 (es) 2000-02-16
GR3032457T3 (en) 2000-05-31
NO924309D0 (no) 1992-11-09
CA2083377A1 (en) 1991-11-24
WO1991017755A1 (en) 1991-11-28
EP0531447A1 (en) 1993-03-17
EP0531447A4 (en) 1993-08-11

Similar Documents

Publication Publication Date Title
DK0531447T3 (da) Præparater og fremgangsmåder til modulering af RNA-aktivitet ved modifikation af 5'-cap-strukturen af RNA
PL334530A1 (en) Novel genes specific in respect to n-axecetyl-l-phosphotricin, used to code amino acids deacetylase, their isolation and application
DK0745131T3 (da) Målrettet genterapi
DK288183D0 (da) Fremgangsmade til fremstilling af et oligonucleotidt terapeutisk middel
DK0672180T3 (da) Oligonukleotidmodulering af protein kinase C
DE69634698D1 (de) Gewebespezifische und ziel-rna-spezifische ribozyme
EP0240332A3 (en) Virus resistant plants having antisense rna
DE69333491D1 (en) Protease-resistente analoge des thrombomodulin
DE69333812D1 (de) Endo-Xyloglucan-Transferase
DE19681032D2 (de) Gentherapeutisches Nukleinsäurekonstrukt, seine Herstellung und Verwendung zur Behandlung von Herzerkrankungen
ATE209683T1 (de) Planze resistent gegen mindestens zwei viren und dessen preparation
ATE218372T1 (de) Antisense oligonnukleotide die mit der mrna cap aktivität interferieren und die translation inhibieren
DK268589A (da) Fremgangsmaade til inaktivering af rekombinant dna
ATE232731T1 (de) Verwendung der gensequenz eines promotors zur behandlung rheumatischer erkrankungen
AU2782989A (en) Dna and rna molecules stabilized by modifications of the 3'-terminal phosphodiester linkage and their use as nucleic acid probes and as therapeutic agents to block the expression of specifically targeted genes
UA10281C2 (uk) Спосіб отримання речовини для лікування захворювань підшлункової залози
TH19693B (th) การบำบัดทางชีวภาพโดยเอนไซม์
AU6031598A (en) Enzymatic nucleic acid treatment of diseases or conditions related to levels of c-fos