GR3032457T3 - Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna. - Google Patents

Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna.

Info

Publication number
GR3032457T3
GR3032457T3 GR20000400151T GR20000400151T GR3032457T3 GR 3032457 T3 GR3032457 T3 GR 3032457T3 GR 20000400151 T GR20000400151 T GR 20000400151T GR 20000400151 T GR20000400151 T GR 20000400151T GR 3032457 T3 GR3032457 T3 GR 3032457T3
Authority
GR
Greece
Prior art keywords
rna
cap structure
modification
methods
compositions
Prior art date
Application number
GR20000400151T
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3032457T3 publication Critical patent/GR3032457T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
GR20000400151T 1990-05-23 2000-01-25 Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna. GR3032457T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52759990A 1990-05-23 1990-05-23
PCT/US1991/003606 WO1991017755A1 (en) 1990-05-23 1991-05-22 Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna

Publications (1)

Publication Number Publication Date
GR3032457T3 true GR3032457T3 (en) 2000-05-31

Family

ID=24102143

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000400151T GR3032457T3 (en) 1990-05-23 2000-01-25 Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna.

Country Status (15)

Country Link
EP (1) EP0531447B1 (el)
JP (1) JPH06500075A (el)
KR (1) KR960004931B1 (el)
AT (1) ATE186464T1 (el)
AU (1) AU649458B2 (el)
BR (1) BR9106486A (el)
CA (1) CA2083377C (el)
DE (1) DE69131773T2 (el)
DK (1) DK0531447T3 (el)
ES (1) ES2139578T3 (el)
FI (1) FI925210A (el)
GR (1) GR3032457T3 (el)
HU (1) HUT63568A (el)
NO (1) NO924309D0 (el)
WO (1) WO1991017755A1 (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789573A (en) * 1990-08-14 1998-08-04 Isis Pharmaceuticals, Inc. Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
DE69430740T2 (de) * 1993-04-01 2003-02-06 Isis Pharmaceuticals Inc ANTISENSE OLIGONNUKLEOTIDE DIE MIT DER mRNA CAP AKTIVITÄT INTERFERIEREN UND DIE TRANSLATION INHIBIEREN
IL114235A0 (en) * 1994-07-14 1995-10-31 Schering Ag Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same
US6380169B1 (en) * 1994-08-31 2002-04-30 Isis Pharmaceuticals, Inc. Metal complex containing oligonucleoside cleavage compounds and therapies
US5962271A (en) * 1996-01-03 1999-10-05 Cloutech Laboratories, Inc. Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
WO2001062981A1 (en) * 2000-02-25 2001-08-30 Montclair Group Platform for the discovery of the bacterial genes involved in rna modification
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
MX356830B (es) 2012-07-13 2018-06-15 Shin Nippon Biomedical Laboratories Ltd Adyuvante de acido nucleico quiral.
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
DE69133405T2 (de) * 1990-01-11 2005-07-07 Isis Pharmaceutical, Inc., Carlsbad Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression

Also Published As

Publication number Publication date
EP0531447A1 (en) 1993-03-17
NO924309L (no) 1992-11-09
KR960004931B1 (ko) 1996-04-18
JPH06500075A (ja) 1994-01-06
HUT63568A (en) 1993-09-28
AU649458B2 (en) 1994-05-26
NO924309D0 (no) 1992-11-09
FI925210A0 (fi) 1992-11-17
FI925210A (fi) 1992-11-17
CA2083377A1 (en) 1991-11-24
CA2083377C (en) 2002-11-26
DK0531447T3 (da) 2000-03-27
EP0531447A4 (en) 1993-08-11
KR930700118A (ko) 1993-03-13
ATE186464T1 (de) 1999-11-15
EP0531447B1 (en) 1999-11-10
WO1991017755A1 (en) 1991-11-28
DE69131773T2 (de) 2000-03-02
AU8080291A (en) 1991-12-10
DE69131773D1 (de) 1999-12-16
HU9203659D0 (en) 1993-04-28
BR9106486A (pt) 1993-05-25
ES2139578T3 (es) 2000-02-16

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