ATE174385T1 - Immunglobulin-a1-proteasen (iga1-proteasen), verfahren zur gentechnologischen herstellung dieses enzymtyps sowie impfstoffe, die die enzyme und fragmente davon enthalten, zur immunisierung gegen bakterielle meningitis und andere, durch iga1-proteaseproduzierende bakterien verursachte krankheiten - Google Patents
Immunglobulin-a1-proteasen (iga1-proteasen), verfahren zur gentechnologischen herstellung dieses enzymtyps sowie impfstoffe, die die enzyme und fragmente davon enthalten, zur immunisierung gegen bakterielle meningitis und andere, durch iga1-proteaseproduzierende bakterien verursachte krankheitenInfo
- Publication number
- ATE174385T1 ATE174385T1 AT90905191T AT90905191T ATE174385T1 AT E174385 T1 ATE174385 T1 AT E174385T1 AT 90905191 T AT90905191 T AT 90905191T AT 90905191 T AT90905191 T AT 90905191T AT E174385 T1 ATE174385 T1 AT E174385T1
- Authority
- AT
- Austria
- Prior art keywords
- protease
- iga1
- proteases
- influenzae
- iga
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 6
- 239000004365 Protease Substances 0.000 title abstract 6
- 102000035195 Peptidases Human genes 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 title 2
- 108090000790 Enzymes Proteins 0.000 title 2
- 101100396606 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) iga gene Proteins 0.000 title 2
- 241000894006 Bacteria Species 0.000 title 1
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 206010027202 Meningitis bacterial Diseases 0.000 title 1
- 201000009904 bacterial meningitis Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 238000002649 immunization Methods 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 108010002231 IgA-specific serine endopeptidase Proteins 0.000 abstract 6
- 241000606768 Haemophilus influenzae Species 0.000 abstract 4
- 108700026244 Open Reading Frames Proteins 0.000 abstract 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 3
- 101150026046 iga gene Proteins 0.000 abstract 3
- 241000588652 Neisseria gonorrhoeae Species 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 108700010070 Codon Usage Proteins 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 201000009906 Meningitis Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 229940047650 haemophilus influenzae Drugs 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 230000004481 post-translational protein modification Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
- 239000000304 virulence factor Substances 0.000 abstract 1
- 230000007923 virulence factor Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK130889A DK130889A (da) | 1989-03-17 | 1989-03-17 | Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174385T1 true ATE174385T1 (de) | 1998-12-15 |
Family
ID=8103403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90905191T ATE174385T1 (de) | 1989-03-17 | 1990-03-16 | Immunglobulin-a1-proteasen (iga1-proteasen), verfahren zur gentechnologischen herstellung dieses enzymtyps sowie impfstoffe, die die enzyme und fragmente davon enthalten, zur immunisierung gegen bakterielle meningitis und andere, durch iga1-proteaseproduzierende bakterien verursachte krankheiten |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0463073B1 (de) |
| JP (1) | JPH04503756A (de) |
| AT (1) | ATE174385T1 (de) |
| AU (1) | AU630443B2 (de) |
| CA (1) | CA2049984A1 (de) |
| DE (1) | DE69032821D1 (de) |
| DK (1) | DK130889A (de) |
| FI (1) | FI100723B (de) |
| NO (1) | NO304745B1 (de) |
| WO (1) | WO1990011367A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965424A (en) * | 1991-01-11 | 1999-10-12 | Boehringer Mannheim Gmbh | Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases |
| DE4140699A1 (de) * | 1991-01-11 | 1992-07-16 | Boehringer Mannheim Gmbh | Rekombinante iga-protease |
| GB9201013D0 (en) * | 1992-01-17 | 1992-03-11 | Animal Health Inst | Vaccines |
| US6245337B1 (en) | 1994-08-25 | 2001-06-12 | Washington University | Haemophilus adherence and penetration proteins |
| US6676948B2 (en) | 1994-08-25 | 2004-01-13 | Washington University | Haemophilus adherence and penetration proteins |
| WO1996009395A2 (de) * | 1994-09-21 | 1996-03-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Arzneimittel zur prophylaxe und behandlung von und diagnostika zur erkennung von autoimmunkrankheiten und viralen erkrankungen |
| US6559359B1 (en) * | 1996-09-09 | 2003-05-06 | Loyola University Of Chicago | Plant retroviral polynucleotides and methods for use thereof |
| DK0895537T3 (da) * | 1997-01-21 | 2005-03-29 | Max Planck Gesellschaft | IGA1 proteasefragment som bærerpeptid |
| DE19741955A1 (de) * | 1997-09-23 | 1999-04-01 | Max Planck Gesellschaft | Mittel gegen bakterielle Meningitis |
| JP5438886B2 (ja) * | 2003-03-07 | 2014-03-12 | タフツ メディカル センター インコーポレイテッド | ＩｇＡ１沈着症の治療 |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| US8440191B2 (en) | 2005-11-18 | 2013-05-14 | Tufts Medical Center | Clearance of abnormal IGA1 in IGA1 deposition diseases |
| US8841109B2 (en) | 2009-04-20 | 2014-09-23 | The University Of Kansas | IGA1 protease polypeptide agents and uses thereof |
| RU2407792C1 (ru) * | 2009-10-05 | 2010-12-27 | Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН | СПОСОБ ПОЛУЧЕНИЯ IgAl-ПРОТЕАЗЫ ИЗ КУЛЬТУРЫ NEISSERIA MENINGITIDIS СЕРОГРУППЫ А И ИММУНОГЕННЫЙ ПРЕПАРАТ НА ЕЕ ОСНОВЕ |
| RU2426126C1 (ru) * | 2010-05-28 | 2011-08-10 | Федеральное государственное учреждение науки "Казанский научно-исследовательский институт эпидемиологии и микробиологии" Роспотребнадзора | СПОСОБ ОПРЕДЕЛЕНИЯ IgA-ПРОТЕИНАЗНОЙ АКТИВНОСТИ |
| GB201120634D0 (en) * | 2011-11-30 | 2012-01-11 | Univ Sheffield | Adjuvant polypeptide |
| WO2017137085A1 (en) | 2016-02-11 | 2017-08-17 | Sanofi Pasteur | Meningitidis vaccines comprising subtilinases |
-
1989
- 1989-03-17 DK DK130889A patent/DK130889A/da unknown
-
1990
- 1990-03-16 AT AT90905191T patent/ATE174385T1/de active
- 1990-03-16 CA CA002049984A patent/CA2049984A1/en not_active Abandoned
- 1990-03-16 DE DE69032821T patent/DE69032821D1/de not_active Expired - Lifetime
- 1990-03-16 WO PCT/DK1990/000073 patent/WO1990011367A1/en not_active Ceased
- 1990-03-16 JP JP2505143A patent/JPH04503756A/ja active Pending
- 1990-03-16 EP EP90905191A patent/EP0463073B1/de not_active Expired - Lifetime
- 1990-03-16 AU AU53447/90A patent/AU630443B2/en not_active Ceased
-
1991
- 1991-09-17 NO NO913665A patent/NO304745B1/no unknown
- 1991-09-17 FI FI914356A patent/FI100723B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0463073B1 (de) | 1998-12-09 |
| AU630443B2 (en) | 1992-10-29 |
| NO304745B1 (no) | 1999-02-08 |
| NO913665D0 (no) | 1991-09-17 |
| FI100723B (fi) | 1998-02-13 |
| NO913665L (no) | 1991-11-18 |
| AU5344790A (en) | 1990-10-22 |
| CA2049984A1 (en) | 1990-09-18 |
| DE69032821D1 (de) | 1999-01-21 |
| JPH04503756A (ja) | 1992-07-09 |
| DK130889A (da) | 1990-09-18 |
| FI914356A0 (fi) | 1991-09-17 |
| EP0463073A1 (de) | 1992-01-02 |
| DK130889D0 (da) | 1989-03-17 |
| WO1990011367A1 (en) | 1990-10-04 |
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