ATE244307T1 - Rekombinante proteine des filamentoesen haemaglutinins von bordetella,im besonderen bordetella pertusis, herstellungsverfahren und ihre verwendung zur herstellung von fremdproteinen oder vakzinen - Google Patents
Rekombinante proteine des filamentoesen haemaglutinins von bordetella,im besonderen bordetella pertusis, herstellungsverfahren und ihre verwendung zur herstellung von fremdproteinen oder vakzinenInfo
- Publication number
- ATE244307T1 ATE244307T1 AT95918030T AT95918030T ATE244307T1 AT E244307 T1 ATE244307 T1 AT E244307T1 AT 95918030 T AT95918030 T AT 95918030T AT 95918030 T AT95918030 T AT 95918030T AT E244307 T1 ATE244307 T1 AT E244307T1
- Authority
- AT
- Austria
- Prior art keywords
- bordetella
- fha
- sequence
- proteins
- pertussis
- Prior art date
Links
- 241000588807 Bordetella Species 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 241000588832 Bordetella pertussis Species 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101710089384 Extracellular protease Proteins 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 239000006143 cell culture medium Substances 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000004897 n-terminal region Anatomy 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 238000011144 upstream manufacturing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9404661A FR2718750B1 (fr) | 1994-04-19 | 1994-04-19 | Protéines recombinantes de l'hémagglutinine filamenteuse de Bordetella, notamment, B. Pertussis, production et application à la production de protéines étrangères ou de principes actifs vaccinants. |
| PCT/FR1995/000512 WO1995028486A2 (fr) | 1994-04-19 | 1995-04-19 | Proteines recombinantes de l'hemagglutinine filamenteuse de bordetella, notamment bordetella pertussis, procede pour leur production et leurs applications a la production de proteines etrangeres ou de principes actifs vaccinants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244307T1 true ATE244307T1 (de) | 2003-07-15 |
Family
ID=9462257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95918030T ATE244307T1 (de) | 1994-04-19 | 1995-04-19 | Rekombinante proteine des filamentoesen haemaglutinins von bordetella,im besonderen bordetella pertusis, herstellungsverfahren und ihre verwendung zur herstellung von fremdproteinen oder vakzinen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6841358B1 (de) |
| EP (1) | EP0755447B1 (de) |
| AT (1) | ATE244307T1 (de) |
| AU (1) | AU2412195A (de) |
| CA (1) | CA2202639C (de) |
| DE (1) | DE69531200T2 (de) |
| DK (1) | DK0755447T3 (de) |
| ES (1) | ES2202363T3 (de) |
| FR (1) | FR2718750B1 (de) |
| PT (1) | PT755447E (de) |
| WO (1) | WO1995028486A2 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932714A (en) * | 1995-02-23 | 1999-08-03 | Connaught Laboratories Limited | Expression of gene products from genetically manipulated strains of Bordetella |
| FR2754543B1 (fr) * | 1996-10-11 | 1998-12-31 | Pasteur Institut | Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires |
| US7087236B1 (en) * | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
| FR2793492A1 (fr) * | 1999-05-11 | 2000-11-17 | Pasteur Institut | Nouveau procede de purification par affinite |
| CA2645190C (en) | 2006-03-10 | 2019-01-15 | Institut Pasteur De Lille | Live attenuated bordetella strains as a single dose vaccine against whooping cough |
| EP2442826B1 (de) | 2009-06-15 | 2015-07-08 | National University of Singapore | Influenzaimpfstoff, zusammensetzung und seine verwendung |
| EP2773371B1 (de) | 2011-11-02 | 2020-01-01 | National University of Singapore | Wirkung eines abgeschwächten bordetella-stamms gegen allergische erkrankungen |
| EP2722338A1 (de) | 2012-10-17 | 2014-04-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Neue rekombinante Bordetella-Stämme |
| WO2014071182A1 (en) | 2012-11-01 | 2014-05-08 | Massachusetts Institute Of Technology | Directed evolution of synthetic gene cluster |
| US9655959B2 (en) | 2014-10-01 | 2017-05-23 | National University Of Singapore | Adenylate cyclase deficient bordetella strains |
| KR102197507B1 (ko) | 2015-07-13 | 2020-12-31 | 피벗 바이오, 인크. | 식물 형질 개선을 위한 방법 및 조성물 |
| WO2017062412A1 (en) | 2015-10-05 | 2017-04-13 | Massachusetts Institute Of Technology | Nitrogen fixation using refactored nif clusters |
| FI3436034T3 (fi) | 2016-03-29 | 2025-05-08 | Pasteur Institut | Mutantteja bordetella-kantoja ja käyttömenetelmiä |
| UA129256C2 (uk) | 2017-01-12 | 2025-03-05 | Півот Байо, Інк. | Спосіб ідентифікації штаму мікроорганізму, який продукує азот, небобова рослина, колонізована таким штамом, спосіб збільшення фіксації азоту у небобових рослин та композиція для збільшення фіксації азоту у небобових рослин |
| CN111542507A (zh) * | 2017-08-09 | 2020-08-14 | 皮沃特生物股份有限公司 | 用于改善工程改造的微生物的方法和组合物 |
| CA3077428A1 (en) | 2017-10-18 | 2019-04-25 | Institut Pasteur De Lille | Bordetella strains expressing serotype 3 fimbriae |
| JP7420712B2 (ja) | 2017-10-25 | 2024-01-23 | ピボット バイオ， インコーポレイテッド | 窒素を固定する操作された微生物を改良するための方法および組成物 |
| US12151988B2 (en) | 2017-10-25 | 2024-11-26 | Pivot Bio, Inc. | Gene targets for nitrogen fixation targeting for improving plant traits |
| EP3813511A4 (de) | 2018-06-27 | 2022-08-03 | Pivot Bio, Inc. | Geführte mikrobielle remodellierung, plattform zur rationellen verbesserung mikrobieller spezies für die landwirtschaft |
| EP3814302A4 (de) | 2018-06-27 | 2022-06-29 | Pivot Bio, Inc. | Landwirtschaftliche zusammensetzungen mit remodellierten stickstofffixierenden mikroben |
| US12391624B2 (en) | 2018-07-11 | 2025-08-19 | Pivot Bio, Inc. | Temporally and spatially targeted dynamic nitrogen delivery by remodeled microbes |
| US12421519B2 (en) | 2019-01-07 | 2025-09-23 | Pivot Bio, Inc. | Plant colonization assays using natural microbial barcodes |
| WO2020190363A1 (en) | 2019-03-19 | 2020-09-24 | Massachusetts Institute Of Technology | Control of nitrogen fixation in rhizobia that associate with cereals |
| CN114008221A (zh) | 2019-04-25 | 2022-02-01 | 皮沃特生物股份有限公司 | 用于分离和表征由化学诱变产生的泌铵突变体库的高通量方法 |
| AU2020445067A1 (en) | 2020-05-01 | 2022-12-01 | Pivot Bio, Inc. | Measurement of nitrogen fixation and incorporation |
| WO2021222643A1 (en) | 2020-05-01 | 2021-11-04 | Pivot Bio, Inc. | Stable liquid formulations for nitrogen-fixing microorganisms |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6036960A (en) * | 1988-10-27 | 2000-03-14 | Relman; David A. | Filamentous hemagglutinin of B. pertussis |
| CA1341123C (en) * | 1988-10-27 | 2000-10-17 | David A. Relman | Filamentous hemagglutinin of b. pertussis |
| GB9008746D0 (en) * | 1990-04-18 | 1990-06-13 | Connaught Lab | The use of autologous promoters to express gene products in bordetella |
| DE4111531A1 (de) * | 1991-04-09 | 1992-10-29 | Biotechnolog Forschung Gmbh | Plasmide zur fha-expression und wirte |
-
1994
- 1994-04-19 FR FR9404661A patent/FR2718750B1/fr not_active Expired - Fee Related
-
1995
- 1995-04-19 CA CA002202639A patent/CA2202639C/fr not_active Expired - Fee Related
- 1995-04-19 ES ES95918030T patent/ES2202363T3/es not_active Expired - Lifetime
- 1995-04-19 DK DK95918030T patent/DK0755447T3/da active
- 1995-04-19 WO PCT/FR1995/000512 patent/WO1995028486A2/fr not_active Ceased
- 1995-04-19 DE DE69531200T patent/DE69531200T2/de not_active Expired - Lifetime
- 1995-04-19 US US08/765,287 patent/US6841358B1/en not_active Expired - Fee Related
- 1995-04-19 PT PT95918030T patent/PT755447E/pt unknown
- 1995-04-19 AU AU24121/95A patent/AU2412195A/en not_active Abandoned
- 1995-04-19 EP EP95918030A patent/EP0755447B1/de not_active Expired - Lifetime
- 1995-04-19 AT AT95918030T patent/ATE244307T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| PT755447E (pt) | 2003-12-31 |
| EP0755447B1 (de) | 2003-07-02 |
| WO1995028486A3 (fr) | 1996-01-11 |
| US6841358B1 (en) | 2005-01-11 |
| DE69531200T2 (de) | 2004-04-15 |
| CA2202639A1 (fr) | 1995-10-26 |
| AU2412195A (en) | 1995-11-10 |
| DK0755447T3 (da) | 2003-10-27 |
| DE69531200D1 (de) | 2003-08-07 |
| FR2718750B1 (fr) | 1996-06-14 |
| WO1995028486A2 (fr) | 1995-10-26 |
| ES2202363T3 (es) | 2004-04-01 |
| CA2202639C (fr) | 2004-08-10 |
| FR2718750A1 (fr) | 1995-10-20 |
| EP0755447A1 (de) | 1997-01-29 |
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