DK130889A - Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier - Google Patents

Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier

Info

Publication number
DK130889A
DK130889A DK130889A DK130889A DK130889A DK 130889 A DK130889 A DK 130889A DK 130889 A DK130889 A DK 130889A DK 130889 A DK130889 A DK 130889A DK 130889 A DK130889 A DK 130889A
Authority
DK
Denmark
Prior art keywords
protease
iga1
proteases
influenzae
enzymes
Prior art date
Application number
DK130889A
Other languages
English (en)
Other versions
DK130889D0 (da
Inventor
Mogens Kilian
Knud Poulsen
Original Assignee
Mogens Kilian
Knud Poulsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mogens Kilian, Knud Poulsen filed Critical Mogens Kilian
Priority to DK130889A priority Critical patent/DK130889A/da
Publication of DK130889D0 publication Critical patent/DK130889D0/da
Priority to DE69032821T priority patent/DE69032821D1/de
Priority to AT90905191T priority patent/ATE174385T1/de
Priority to AU53447/90A priority patent/AU630443B2/en
Priority to JP2505143A priority patent/JPH04503756A/ja
Priority to EP90905191A priority patent/EP0463073B1/en
Priority to CA002049984A priority patent/CA2049984A1/en
Priority to PCT/DK1990/000073 priority patent/WO1990011367A1/en
Publication of DK130889A publication Critical patent/DK130889A/da
Priority to NO913665A priority patent/NO304745B1/no
Priority to FI914356A priority patent/FI100723B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK130889A 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier DK130889A (da)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK130889A DK130889A (da) 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier
PCT/DK1990/000073 WO1990011367A1 (en) 1989-03-17 1990-03-16 IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA
JP2505143A JPH04503756A (ja) 1989-03-17 1990-03-16 免疫グロブリンＡ１プロテアーゼ（ＩｇＡ１プロテアーゼ）、このタイプの酵素を遺伝子工学的に製造するための方法及びＩｇＡ１プロテアーゼ生成細菌により引き起こされる細菌性脳膜炎及び他の疾患に対して免疫化するために前記酵素及びそのフラグメントを含むワクチン
AT90905191T ATE174385T1 (de) 1989-03-17 1990-03-16 Immunglobulin-a1-proteasen (iga1-proteasen), verfahren zur gentechnologischen herstellung dieses enzymtyps sowie impfstoffe, die die enzyme und fragmente davon enthalten, zur immunisierung gegen bakterielle meningitis und andere, durch iga1-proteaseproduzierende bakterien verursachte krankheiten
AU53447/90A AU630443B2 (en) 1989-03-17 1990-03-16 Immunoglobulin a1 proteases (iga1 proteases), method of gene-technologically producing this type of enzyme and vaccines containing the enzymes and fragments thereof for immunizing against bacterial meningitis and other diseases caused by iga1 protease-producing bacteria
DE69032821T DE69032821D1 (de) 1989-03-17 1990-03-16 Immunglobulin-a1-proteasen (iga1-proteasen), verfahren zur gentechnologischen herstellung dieses enzymtyps sowie impfstoffe, die die enzyme und fragmente davon enthalten, zur immunisierung gegen bakterielle meningitis und andere, durch iga1-proteaseproduzierende bakterien verursachte krankheiten
EP90905191A EP0463073B1 (en) 1989-03-17 1990-03-16 IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA
CA002049984A CA2049984A1 (en) 1989-03-17 1990-03-16 Immunoglobulin al proteases (iga1 proteases), method of gene-technologically producing this type of enzyme and vaccines containing the enzymes and fragments thereof for immunizingagainst bacterial meningitis and other diseases caused by iga1 protease-producing bacteria
NO913665A NO304745B1 (no) 1989-03-17 1991-09-17 Fremgangsmaate for fremstilling av immunglobulin A1-protease (IgA1-protease) eller immunogene fragmen ter derav
FI914356A FI100723B (fi) 1989-03-17 1991-09-17 Menetelmä immunoglobuliini-A1-proteaasin (IgA1-proteaasin) tai sen fra gmenttien valmistamiseksi geenitekniikalla ja IgA1-proteaasia koodaava geeni

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK130889A DK130889A (da) 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier

Publications (2)

Publication Number Publication Date
DK130889D0 DK130889D0 (da) 1989-03-17
DK130889A true DK130889A (da) 1990-09-18

Family

ID=8103403

Family Applications (1)

Application Number Title Priority Date Filing Date
DK130889A DK130889A (da) 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier

Country Status (10)

Country Link
EP (1) EP0463073B1 (da)
JP (1) JPH04503756A (da)
AT (1) ATE174385T1 (da)
AU (1) AU630443B2 (da)
CA (1) CA2049984A1 (da)
DE (1) DE69032821D1 (da)
DK (1) DK130889A (da)
FI (1) FI100723B (da)
NO (1) NO304745B1 (da)
WO (1) WO1990011367A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4140699A1 (de) * 1991-01-11 1992-07-16 Boehringer Mannheim Gmbh Rekombinante iga-protease
US5965424A (en) * 1991-01-11 1999-10-12 Boehringer Mannheim Gmbh Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases
GB9201013D0 (en) * 1992-01-17 1992-03-11 Animal Health Inst Vaccines
US6676948B2 (en) 1994-08-25 2004-01-13 Washington University Haemophilus adherence and penetration proteins
US6245337B1 (en) 1994-08-25 2001-06-12 Washington University Haemophilus adherence and penetration proteins
AU3651595A (en) * 1994-09-21 1996-04-09 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Drug for the prevention and treatment of auto-immune and viral diseases, and diagnostic agents for detecting said diseases
JP2001500009A (ja) * 1996-09-09 2001-01-09 ロヨラ ユニバーシティ オブ シカゴ 植物レトロウイルスポリヌクレオチドおよびその使用のための方法
WO1998031791A1 (en) * 1997-01-21 1998-07-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Iga1 protease fragment as carrier peptide
DE19741955A1 (de) * 1997-09-23 1999-04-01 Max Planck Gesellschaft Mittel gegen bakterielle Meningitis
EP1603511B1 (en) 2003-03-07 2011-01-26 New England Medical Center Hospitals, Inc. Treatment of igai deposition diseases
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
US8440191B2 (en) 2005-11-18 2013-05-14 Tufts Medical Center Clearance of abnormal IGA1 in IGA1 deposition diseases
US8841109B2 (en) 2009-04-20 2014-09-23 The University Of Kansas IGA1 protease polypeptide agents and uses thereof
RU2407792C1 (ru) * 2009-10-05 2010-12-27 Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН СПОСОБ ПОЛУЧЕНИЯ IgAl-ПРОТЕАЗЫ ИЗ КУЛЬТУРЫ NEISSERIA MENINGITIDIS СЕРОГРУППЫ А И ИММУНОГЕННЫЙ ПРЕПАРАТ НА ЕЕ ОСНОВЕ
GB201120634D0 (en) * 2011-11-30 2012-01-11 Univ Sheffield Adjuvant polypeptide
WO2017137085A1 (en) 2016-02-11 2017-08-17 Sanofi Pasteur Meningitidis vaccines comprising subtilinases

Also Published As

Publication number Publication date
CA2049984A1 (en) 1990-09-18
EP0463073A1 (en) 1992-01-02
EP0463073B1 (en) 1998-12-09
NO304745B1 (no) 1999-02-08
AU5344790A (en) 1990-10-22
JPH04503756A (ja) 1992-07-09
DE69032821D1 (de) 1999-01-21
DK130889D0 (da) 1989-03-17
AU630443B2 (en) 1992-10-29
NO913665D0 (no) 1991-09-17
FI100723B (fi) 1998-02-13
NO913665L (no) 1991-11-18
ATE174385T1 (de) 1998-12-15
WO1990011367A1 (en) 1990-10-04
FI914356A0 (fi) 1991-09-17

Similar Documents

Publication Publication Date Title
DK130889D0 (da) Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier
Sugai et al. Purification and molecular characterization of glycylglycine endopeptidase produced by Staphylococcus capitis EPK1
RU95117238A (ru) Нуклеиновая кислота, рекомбинантная плазмида, рекомбинантный вектор, белок, синтетический пептид, химерная молекула, иммуногенная композиция, антисыворотка или антитела
FI910960A (fi) Dna-fragment, som kodar en polypeptid med nitrilhydratasaktivitet, transformant innehaollande genen och foerfarande foer framstaellning av amiderar med hjaelp av transformanten.
CA2356836A1 (en) Novel streptococcus antigens
HU0004115D0 (da)
Wintermeyer et al. Characterization of legiolysin (lly), responsible for haemolytic activity, colour production and fluorescence of Legionella pneumophila
Pinkney et al. Different forms of streptolysin O produced by Streptococcus pyogenes and by Escherichia coli expressing recombinant toxin: cleavage by streptococcal cysteine protease
Nicaud et al. Regulation of haemolysin synthesis in E. coli determined by HLY genes of human origin
Schad et al. Nucleotide sequence and expression in Escherichia coli of the Pseudomonas aeruginosa lasA gene
US5352588A (en) Streptococcal immunoglobulin a binding protein encoded by emmL2.2
Hu et al. Morganella morganii urease: purification, characterization, and isolation of gene sequences
DK128490D0 (da) Renset gensekvens, som koder for protein ia, ib eller begge fra neisseria gonorrhoeae, rekombinantvektorer og organismer indeholdende sekvenser, dens fremstilling og anvendelse, neisseria-stamme og dennes paavisning
KR19990007306A (ko) 클로스트리디움 페르프링겐스 백신
Gerlach et al. Characterization of two genes encoding antigenically distinct type-1 fimbriae of Klebsiella pneumoniae
Willemsen et al. Characterization of a periplasmic protein involved in iron utilization of Actinobacillus actinomycetemcomitans
Brok et al. Sequence comparison of outer membrane phospholipases A: implications for structure and for the catalytic mechanism
JPH10290695A (ja) アクチノバシラス・プレウロニューモニアの弱毒化生菌
Nomura et al. Carboxy terminal region of haemolysin of Aeromonas sobria triggers dimerization
Terauchi et al. Cloning of the gene coding for Staphylococcus intermedius exfoliative toxin and its expression in Escherichia coli
MIYAMoTo et al. Cloning and nucleotide sequence of the gene encoding a serine proteinase inhibitor named marinostatin from a marine bacterium, Alteromonas sp. strain B-10-31
Igarashi et al. Detection of dextranase‐producing gram‐negative oral bacteria
RU2003107837A (ru) Гены и белки и их применения
JP3532510B2 (ja) 組換え豚丹毒菌防御抗原の回収精製法
Chestukhina et al. Amino acid sequences from the N-terminal domain of Bacillus thuringiensis, subspecies alesti, δ-endotoxin: Hypervariable regions of Bacillus thuringiensis δ-endotoxms