ATE174324T1 - Hexahydronaphthalenesterderivate, ihre herstellung und ihre therapeutischen anwendungen - Google Patents
Hexahydronaphthalenesterderivate, ihre herstellung und ihre therapeutischen anwendungenInfo
- Publication number
- ATE174324T1 ATE174324T1 AT94300557T AT94300557T ATE174324T1 AT E174324 T1 ATE174324 T1 AT E174324T1 AT 94300557 T AT94300557 T AT 94300557T AT 94300557 T AT94300557 T AT 94300557T AT E174324 T1 ATE174324 T1 AT E174324T1
- Authority
- AT
- Austria
- Prior art keywords
- hexahydronaphthalene
- preparation
- therapeutic applications
- hydrogen
- formula
- Prior art date
Links
- IKAACYWAXDLDPM-UHFFFAOYSA-N 1,2,3,4,4a,5-hexahydronaphthalene Chemical class C1=CCC2CCCCC2=C1 IKAACYWAXDLDPM-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 208000020446 Cardiac disease Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1306393 | 1993-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174324T1 true ATE174324T1 (de) | 1998-12-15 |
Family
ID=11822687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94300557T ATE174324T1 (de) | 1993-01-29 | 1994-01-26 | Hexahydronaphthalenesterderivate, ihre herstellung und ihre therapeutischen anwendungen |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5491167A (de) |
| EP (1) | EP0609058B1 (de) |
| JP (1) | JPH06279280A (de) |
| KR (1) | KR100293335B1 (de) |
| CN (1) | CN1070487C (de) |
| AT (1) | ATE174324T1 (de) |
| AU (1) | AU664323B2 (de) |
| CA (1) | CA2114450A1 (de) |
| CZ (1) | CZ285658B6 (de) |
| DE (1) | DE69415050T2 (de) |
| DK (1) | DK0609058T3 (de) |
| ES (1) | ES2126057T3 (de) |
| FI (1) | FI940424A (de) |
| HK (1) | HK1011678A1 (de) |
| HU (1) | HU221852B1 (de) |
| IL (1) | IL108432A (de) |
| NO (1) | NO300769B1 (de) |
| NZ (1) | NZ250771A (de) |
| PH (1) | PH31662A (de) |
| RU (1) | RU2114101C1 (de) |
| TW (1) | TW411337B (de) |
| ZA (1) | ZA94548B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| US6043064A (en) * | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| US5942423A (en) * | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| AU2002211805A1 (en) * | 2000-09-06 | 2002-03-22 | Emisphere Technologies, Inc. | Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents |
| PL2152670T3 (pl) | 2007-04-27 | 2014-05-30 | Idorsia Pharmaceuticals Ltd | Mostkowane sześcioczłonowe związki pierścieniowe |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS57185275A (en) * | 1981-05-07 | 1982-11-15 | Sankyo Co Ltd | Tetrahydro-dum-4 and tetrahydro-isodum-4 and their derivatives |
| US4668699A (en) * | 1985-08-05 | 1987-05-26 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US4937264A (en) * | 1986-05-05 | 1990-06-26 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4876279A (en) * | 1986-05-05 | 1989-10-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4937263A (en) * | 1986-05-05 | 1990-06-26 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4902709A (en) * | 1987-03-17 | 1990-02-20 | Merck & Co., Inc. | Novel antihypercholesterolemic compounds |
| US4885314A (en) * | 1987-06-29 | 1989-12-05 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| US4946864A (en) * | 1988-02-01 | 1990-08-07 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US5021453A (en) * | 1988-03-02 | 1991-06-04 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| US5180589A (en) * | 1988-03-31 | 1993-01-19 | E. R. Squibb & Sons, Inc. | Pravastatin pharmaceuatical compositions having good stability |
| US4963538A (en) * | 1988-06-29 | 1990-10-16 | Merck & Co., Inc. | 5-oxygenated HMG-CoA reductase inhibitors |
| US5130306A (en) * | 1989-03-13 | 1992-07-14 | Merck & Co., Inc. | 5-Oxygenated HMG-COA reductase inhibitors |
| US5102911A (en) * | 1989-06-09 | 1992-04-07 | Merck & Co, Inc. | 4-Substituted HMG-CoA reductase inhibitors |
| US5010105A (en) * | 1989-06-09 | 1991-04-23 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DE69008277D1 (de) * | 1989-08-31 | 1994-05-26 | Merck & Co Inc | 7-Subsituierte HMG-CoA-Reduktase-Inhibitoren. |
-
1994
- 1994-01-25 IL IL108432A patent/IL108432A/xx not_active IP Right Cessation
- 1994-01-26 ES ES94300557T patent/ES2126057T3/es not_active Expired - Lifetime
- 1994-01-26 DK DK94300557T patent/DK0609058T3/da active
- 1994-01-26 AT AT94300557T patent/ATE174324T1/de not_active IP Right Cessation
- 1994-01-26 EP EP94300557A patent/EP0609058B1/de not_active Expired - Lifetime
- 1994-01-26 ZA ZA94548A patent/ZA94548B/xx unknown
- 1994-01-26 DE DE69415050T patent/DE69415050T2/de not_active Expired - Fee Related
- 1994-01-27 CZ CZ94186A patent/CZ285658B6/cs unknown
- 1994-01-27 NZ NZ250771A patent/NZ250771A/en unknown
- 1994-01-28 AU AU54728/94A patent/AU664323B2/en not_active Ceased
- 1994-01-28 RU RU94002313A patent/RU2114101C1/ru not_active IP Right Cessation
- 1994-01-28 FI FI940424A patent/FI940424A/fi unknown
- 1994-01-28 TW TW083100729A patent/TW411337B/zh not_active IP Right Cessation
- 1994-01-28 PH PH47685A patent/PH31662A/en unknown
- 1994-01-28 CA CA002114450A patent/CA2114450A1/en not_active Abandoned
- 1994-01-28 HU HU9400242A patent/HU221852B1/hu not_active IP Right Cessation
- 1994-01-28 NO NO940309A patent/NO300769B1/no not_active IP Right Cessation
- 1994-01-29 CN CN94102611A patent/CN1070487C/zh not_active Expired - Fee Related
- 1994-01-29 KR KR1019940001663A patent/KR100293335B1/ko not_active IP Right Cessation
- 1994-01-31 JP JP6009771A patent/JPH06279280A/ja not_active Withdrawn
- 1994-01-31 US US08/189,040 patent/US5491167A/en not_active Expired - Fee Related
-
1998
- 1998-12-03 HK HK98112767A patent/HK1011678A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO940309L (no) | 1994-08-01 |
| NZ250771A (en) | 1995-07-26 |
| NO940309D0 (no) | 1994-01-28 |
| HU9400242D0 (en) | 1994-05-30 |
| HU221852B1 (hu) | 2003-02-28 |
| ZA94548B (en) | 1994-08-29 |
| DK0609058T3 (da) | 1999-08-16 |
| AU664323B2 (en) | 1995-11-09 |
| AU5472894A (en) | 1994-08-04 |
| KR100293335B1 (ko) | 2001-09-17 |
| ES2126057T3 (es) | 1999-03-16 |
| FI940424A0 (fi) | 1994-01-28 |
| HUT67740A (en) | 1995-04-28 |
| DE69415050D1 (de) | 1999-01-21 |
| EP0609058B1 (de) | 1998-12-09 |
| CN1070487C (zh) | 2001-09-05 |
| PH31662A (en) | 1999-01-12 |
| US5491167A (en) | 1996-02-13 |
| CZ285658B6 (cs) | 1999-10-13 |
| EP0609058A3 (de) | 1995-04-19 |
| JPH06279280A (ja) | 1994-10-04 |
| DE69415050T2 (de) | 1999-08-12 |
| RU2114101C1 (ru) | 1998-06-27 |
| KR940018352A (ko) | 1994-08-16 |
| CN1098099A (zh) | 1995-02-01 |
| HK1011678A1 (en) | 1999-07-16 |
| IL108432A0 (en) | 1994-04-12 |
| FI940424A (fi) | 1994-11-07 |
| CA2114450A1 (en) | 1994-07-30 |
| NO300769B1 (no) | 1997-07-21 |
| EP0609058A2 (de) | 1994-08-03 |
| TW411337B (en) | 2000-11-11 |
| IL108432A (en) | 1997-09-30 |
| CZ18694A3 (en) | 1995-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |