ATE169905T1 - Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten - Google Patents
Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonistenInfo
- Publication number
- ATE169905T1 ATE169905T1 AT95920539T AT95920539T ATE169905T1 AT E169905 T1 ATE169905 T1 AT E169905T1 AT 95920539 T AT95920539 T AT 95920539T AT 95920539 T AT95920539 T AT 95920539T AT E169905 T1 ATE169905 T1 AT E169905T1
- Authority
- AT
- Austria
- Prior art keywords
- antagonists
- derivatives
- tachykine
- alkyldiminine
- substituted
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 102000003141 Tachykinin Human genes 0.000 abstract 2
- 108060008037 tachykinin Proteins 0.000 abstract 2
- 206010011224 Cough Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/262,209 US5597845A (en) | 1994-06-20 | 1994-06-20 | Substituted alkyldiamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE169905T1 true ATE169905T1 (de) | 1998-09-15 |
Family
ID=22996631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95920539T ATE169905T1 (de) | 1994-06-20 | 1995-05-19 | Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5597845A (en:Method) |
| EP (1) | EP0767783B1 (en:Method) |
| JP (1) | JP3920916B2 (en:Method) |
| KR (1) | KR100371981B1 (en:Method) |
| CN (1) | CN1083429C (en:Method) |
| AT (1) | ATE169905T1 (en:Method) |
| AU (1) | AU691619B2 (en:Method) |
| CA (1) | CA2193348C (en:Method) |
| DE (1) | DE69504198T2 (en:Method) |
| DK (1) | DK0767783T3 (en:Method) |
| ES (1) | ES2121389T3 (en:Method) |
| FI (1) | FI115135B (en:Method) |
| HU (1) | HUT75965A (en:Method) |
| IL (1) | IL114185A (en:Method) |
| MX (1) | MX9606654A (en:Method) |
| NO (1) | NO307458B1 (en:Method) |
| NZ (1) | NZ287291A (en:Method) |
| TW (1) | TW442451B (en:Method) |
| WO (1) | WO1995035279A1 (en:Method) |
| ZA (1) | ZA954947B (en:Method) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW541295B (en) * | 1999-01-05 | 2003-07-11 | Nippon Zoki Pharmaceutical Co | A novel substituted alkylteraamine derivative for use as tachykinin antagonist |
| US6613801B2 (en) | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| CN1494425B (zh) | 2001-03-05 | 2011-12-07 | 特兰斯泰克制药公司 | 用作治疗剂的羧酰胺衍生物 |
| CN1235583C (zh) | 2001-03-05 | 2006-01-11 | 特兰斯泰克制药公司 | 用作治疗剂的苯并咪唑衍生物 |
| CN100525763C (zh) | 2002-03-05 | 2009-08-12 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
| US20090263370A1 (en) * | 2006-11-30 | 2009-10-22 | Guoliang Tao | Methods for treating tachykinin-mediated diseases with cholinesterase |
| US8580833B2 (en) | 2009-09-30 | 2013-11-12 | Transtech Pharma, Inc. | Substituted imidazole derivatives and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164372A (en) * | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
| AU687754B2 (en) * | 1990-08-31 | 1998-03-05 | Warner-Lambert Company | Tachykinin antagonists |
| EP0593559A1 (en) * | 1991-07-05 | 1994-04-27 | MERCK SHARP & DOHME LTD. | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
-
1994
- 1994-06-20 US US08/262,209 patent/US5597845A/en not_active Expired - Fee Related
-
1995
- 1995-05-19 CN CN95193680A patent/CN1083429C/zh not_active Expired - Fee Related
- 1995-05-19 EP EP95920539A patent/EP0767783B1/en not_active Expired - Lifetime
- 1995-05-19 DE DE69504198T patent/DE69504198T2/de not_active Expired - Fee Related
- 1995-05-19 ES ES95920539T patent/ES2121389T3/es not_active Expired - Lifetime
- 1995-05-19 JP JP50217396A patent/JP3920916B2/ja not_active Expired - Fee Related
- 1995-05-19 MX MX9606654A patent/MX9606654A/es not_active IP Right Cessation
- 1995-05-19 DK DK95920539T patent/DK0767783T3/da active
- 1995-05-19 HU HU9603540A patent/HUT75965A/hu not_active Application Discontinuation
- 1995-05-19 AT AT95920539T patent/ATE169905T1/de not_active IP Right Cessation
- 1995-05-19 WO PCT/US1995/006317 patent/WO1995035279A1/en not_active Ceased
- 1995-05-19 NZ NZ287291A patent/NZ287291A/xx unknown
- 1995-05-19 CA CA002193348A patent/CA2193348C/en not_active Expired - Fee Related
- 1995-05-19 KR KR1019960707303A patent/KR100371981B1/ko not_active Expired - Fee Related
- 1995-05-19 AU AU25961/95A patent/AU691619B2/en not_active Ceased
- 1995-06-14 ZA ZA954947A patent/ZA954947B/xx unknown
- 1995-06-15 TW TW084106131A patent/TW442451B/zh not_active IP Right Cessation
- 1995-06-16 IL IL11418595A patent/IL114185A/xx not_active IP Right Cessation
-
1996
- 1996-12-18 FI FI965097A patent/FI115135B/fi not_active IP Right Cessation
- 1996-12-19 NO NO965469A patent/NO307458B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI965097A0 (fi) | 1996-12-18 |
| CA2193348C (en) | 1999-08-24 |
| IL114185A (en) | 1999-07-14 |
| TW442451B (en) | 2001-06-23 |
| KR100371981B1 (ko) | 2003-06-12 |
| WO1995035279A1 (en) | 1995-12-28 |
| NO965469L (no) | 1997-02-19 |
| HUT75965A (en) | 1997-05-28 |
| HU9603540D0 (en) | 1997-02-28 |
| AU2596195A (en) | 1996-01-15 |
| ZA954947B (en) | 1996-01-31 |
| CN1083429C (zh) | 2002-04-24 |
| NO307458B1 (no) | 2000-04-10 |
| CA2193348A1 (en) | 1995-12-28 |
| DK0767783T3 (da) | 1999-05-25 |
| DE69504198T2 (de) | 1999-04-29 |
| US5597845A (en) | 1997-01-28 |
| EP0767783A1 (en) | 1997-04-16 |
| IL114185A0 (en:Method) | 1995-10-31 |
| MX9606654A (es) | 1997-12-31 |
| AU691619B2 (en) | 1998-05-21 |
| JPH10501551A (ja) | 1998-02-10 |
| CN1155883A (zh) | 1997-07-30 |
| NO965469D0 (no) | 1996-12-19 |
| EP0767783B1 (en) | 1998-08-19 |
| DE69504198D1 (de) | 1998-09-24 |
| JP3920916B2 (ja) | 2007-05-30 |
| FI115135B (fi) | 2005-03-15 |
| ES2121389T3 (es) | 1998-11-16 |
| NZ287291A (en) | 1998-10-28 |
| FI965097L (fi) | 1996-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |