ATE164585T1 - Kristallisationsverfahren zur herstellung von glycerophosphocholin - Google Patents
Kristallisationsverfahren zur herstellung von glycerophosphocholinInfo
- Publication number
- ATE164585T1 ATE164585T1 AT93901051T AT93901051T ATE164585T1 AT E164585 T1 ATE164585 T1 AT E164585T1 AT 93901051 T AT93901051 T AT 93901051T AT 93901051 T AT93901051 T AT 93901051T AT E164585 T1 ATE164585 T1 AT E164585T1
- Authority
- AT
- Austria
- Prior art keywords
- gpc
- pct
- glycerophosphocholine
- sec
- wet
- Prior art date
Links
- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 title abstract 3
- 229960004956 glycerylphosphorylcholine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229960004788 choline alfoscerate Drugs 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929201371A GB9201371D0 (en) | 1992-01-22 | 1992-01-22 | Crystallisation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE164585T1 true ATE164585T1 (de) | 1998-04-15 |
Family
ID=10709056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93901051T ATE164585T1 (de) | 1992-01-22 | 1992-12-31 | Kristallisationsverfahren zur herstellung von glycerophosphocholin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5523450A (de) |
| EP (1) | EP0643714B1 (de) |
| JP (1) | JPH07504892A (de) |
| AT (1) | ATE164585T1 (de) |
| AU (1) | AU667206B2 (de) |
| CA (1) | CA2126106A1 (de) |
| DE (1) | DE69224999T2 (de) |
| GB (1) | GB9201371D0 (de) |
| WO (1) | WO1993015088A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855323B2 (en) | 2004-02-10 | 2010-12-21 | Monsanto Technology Llc | Recombinant DNA for gene suppression |
| US8981141B1 (en) * | 2011-03-14 | 2015-03-17 | Hanseochem Co., Ltd. | I-and II-type crystals of L-A-glyceryl phosphoryl choline, and method for preparing same |
| US8927755B2 (en) | 2011-03-14 | 2015-01-06 | Hanseochem Co., Ltd. | I- and II-type crystals of L-alpha-glyceryl phosphoryl choline, and method for preparing same |
| KR101287423B1 (ko) * | 2011-03-14 | 2013-07-19 | 주식회사 한서켐 | 글리세릴 포스포릴 콜린의 ii형 결정 |
| KR101287422B1 (ko) * | 2011-03-14 | 2013-07-19 | 주식회사 한서켐 | 글리세릴 포스포릴 콜린의 i형 결정 |
| KR101287425B1 (ko) * | 2013-05-23 | 2013-07-19 | 주식회사 한서켐 | 글리세릴 포스포릴 콜린 ii형 결정의 제조방법 |
| KR101287424B1 (ko) * | 2013-05-23 | 2013-07-19 | 주식회사 한서켐 | 글리세릴 포스포릴 콜린 i형 결정의 제조방법 |
| WO2015108355A1 (ko) * | 2014-01-15 | 2015-07-23 | 지준홍 | 글리세릴 포스포릴 콜린 결정 및 이의 제조 방법 |
| KR101582302B1 (ko) * | 2014-01-15 | 2016-01-06 | 지준홍 | 글리세릴 포스포릴 콜린 결정 및 이의 제조 방법 |
| CN104193778A (zh) * | 2014-08-14 | 2014-12-10 | 苏州富士莱医药股份有限公司 | 液体甘油磷脂酰胆碱的结晶方法 |
| KR20160037031A (ko) * | 2014-09-26 | 2016-04-05 | 엔자이텍 주식회사 | 라세믹 또는 광학적으로 활성이 있는 D 또는 L-α-글리세로포스포릴콜린 고체의 제조방법 |
| CN104356160A (zh) * | 2014-11-05 | 2015-02-18 | 合肥创新医药技术有限公司 | L-α-甘油磷酰胆碱的纯化工艺 |
| CN105001256B (zh) * | 2015-08-12 | 2018-09-25 | 芜湖福民生物药业有限公司 | 甘磷酸胆碱晶体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1229238B (it) * | 1989-05-08 | 1991-07-26 | Istituto Chemioterapico | Procedimento per la preparazione di l-alfa-glicerilfosforilcolina e l alfa glicerilfosforiletanolammina. |
-
1992
- 1992-01-22 GB GB929201371A patent/GB9201371D0/en active Pending
- 1992-12-31 US US08/256,804 patent/US5523450A/en not_active Expired - Fee Related
- 1992-12-31 JP JP5513003A patent/JPH07504892A/ja active Pending
- 1992-12-31 WO PCT/GB1992/002408 patent/WO1993015088A1/en active IP Right Grant
- 1992-12-31 CA CA002126106A patent/CA2126106A1/en not_active Abandoned
- 1992-12-31 DE DE69224999T patent/DE69224999T2/de not_active Expired - Fee Related
- 1992-12-31 AU AU32606/93A patent/AU667206B2/en not_active Ceased
- 1992-12-31 EP EP93901051A patent/EP0643714B1/de not_active Expired - Lifetime
- 1992-12-31 AT AT93901051T patent/ATE164585T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0643714A1 (de) | 1995-03-22 |
| EP0643714B1 (de) | 1998-04-01 |
| US5523450A (en) | 1996-06-04 |
| AU667206B2 (en) | 1996-03-14 |
| CA2126106A1 (en) | 1993-08-05 |
| GB9201371D0 (en) | 1992-03-11 |
| DE69224999T2 (de) | 1998-07-30 |
| JPH07504892A (ja) | 1995-06-01 |
| WO1993015088A1 (en) | 1993-08-05 |
| AU3260693A (en) | 1993-09-01 |
| DE69224999D1 (de) | 1998-05-07 |
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