ATE161848T1 - Glycyrrheticsäurederivate - Google Patents
GlycyrrheticsäurederivateInfo
- Publication number
- ATE161848T1 ATE161848T1 AT92104149T AT92104149T ATE161848T1 AT E161848 T1 ATE161848 T1 AT E161848T1 AT 92104149 T AT92104149 T AT 92104149T AT 92104149 T AT92104149 T AT 92104149T AT E161848 T1 ATE161848 T1 AT E161848T1
- Authority
- AT
- Austria
- Prior art keywords
- glycyrrhetic acid
- acid derivatives
- salt
- antiinflammatory
- antioxidant
- Prior art date
Links
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical class C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 230000003266 anti-allergic effect Effects 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 230000003078 antioxidant effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3128799A JP2998287B2 (ja) | 1991-03-13 | 1991-03-13 | グリチルレチン酸誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE161848T1 true ATE161848T1 (de) | 1998-01-15 |
Family
ID=14993725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92104149T ATE161848T1 (de) | 1991-03-13 | 1992-03-11 | Glycyrrheticsäurederivate |
Country Status (10)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1254321B (it) * | 1992-04-10 | 1995-09-14 | Kemiprogress S R L | Composizione farmaceutica per il trattamento e la prevenzione delle infiammazioni cutanee e della mucosa orale. |
| US5519008A (en) * | 1992-09-10 | 1996-05-21 | Glycomed Incorporated | Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin) |
| US5527890A (en) * | 1993-04-16 | 1996-06-18 | Glycomed Incorporated | Derivatives of triterpenoid acids and uses thereof |
| CN1034334C (zh) * | 1993-08-14 | 1997-03-26 | 贵州省中医研究所 | 齐酞酸钠及其药物组合物 |
| US5866147A (en) * | 1995-05-15 | 1999-02-02 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| US5951990A (en) * | 1995-05-15 | 1999-09-14 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| US5922335A (en) * | 1995-05-15 | 1999-07-13 | Avon Products, Inc. | Uses for ascorbyl-phosphoryl-cholesterol in topical compositions |
| US6162450A (en) * | 1995-05-15 | 2000-12-19 | Avon Products, Inc. | Uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same |
| US5607968A (en) * | 1995-06-07 | 1997-03-04 | Avon Products, Inc. | Topical alkyl-2-O-L-ascorbyl-phosphates |
| EP0843554B1 (en) * | 1996-05-14 | 1999-12-08 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7151082B2 (en) * | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
| JP4271445B2 (ja) | 2001-02-16 | 2009-06-03 | アスビオファーマ株式会社 | Ａｏｐ−１遺伝子又はａｏｐ−１の発現減少を伴う疾患の治療方法及び当該疾患治療薬 |
| US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| JP4792392B2 (ja) * | 2003-09-11 | 2011-10-12 | コーナーストーン セラピューティクス インコーポレイテッド | Ｈｍｇｂ１に対するモノクローナル抗体 |
| WO2007011606A2 (en) * | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| AU2006330807A1 (en) * | 2005-11-28 | 2007-07-05 | Medimmune, Llc | Antagonists of HMBG1 and/or rage and methods of use thereof |
| RU2623876C2 (ru) * | 2014-11-10 | 2017-06-29 | Александр Владимирович Диковский | Фармацевтическая композиция для лечения гиперлипидемии |
| RU2611362C1 (ru) * | 2015-11-26 | 2017-02-21 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Водорастворимая композиция, обладающая противоопухолевой активностью и способ ее получения |
| CN115813859B (zh) * | 2022-12-13 | 2024-05-17 | 五邑大学 | 一种甘草次酸配体脂质体及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL24113A (en) * | 1965-08-08 | 1969-06-25 | Greidinger D | Glycyrrhetic acid phosphoric acid ester and salts thereof |
| GB1093908A (en) * | 1965-11-26 | 1967-12-06 | Biorex Laboratories Ltd | New derivatives of glycyrrhetinic acid |
| GB1229562A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1969-01-17 | 1971-04-28 | ||
| US3734944A (en) * | 1970-05-15 | 1973-05-22 | Biorex Laboratories Ltd | Glycyrrhetinic acid esters |
| GB1476053A (en) * | 1975-02-07 | 1977-06-10 | Biorex Laboratories Ltd | Glycyrrhetinic acid derivatives |
| IL89850A0 (en) * | 1988-04-25 | 1989-12-15 | Takeda Chemical Industries Ltd | Ester of ascorbic acid 2-phosphate |
-
1991
- 1991-03-13 JP JP3128799A patent/JP2998287B2/ja not_active Expired - Lifetime
-
1992
- 1992-03-10 TW TW081101804A patent/TW201750B/zh active
- 1992-03-10 US US07/849,574 patent/US5229378A/en not_active Expired - Fee Related
- 1992-03-11 DE DE69223827T patent/DE69223827T2/de not_active Expired - Fee Related
- 1992-03-11 CA CA002062652A patent/CA2062652A1/en not_active Abandoned
- 1992-03-11 EP EP92104149A patent/EP0503582B1/en not_active Expired - Lifetime
- 1992-03-11 AT AT92104149T patent/ATE161848T1/de not_active IP Right Cessation
- 1992-03-11 ES ES92104149T patent/ES2112870T3/es not_active Expired - Lifetime
- 1992-03-12 RU SU925011293A patent/RU2065864C1/ru active
- 1992-03-13 KR KR1019920004158A patent/KR0185717B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2065864C1 (ru) | 1996-08-27 |
| KR0185717B1 (ko) | 1999-05-15 |
| JPH04330088A (ja) | 1992-11-18 |
| EP0503582B1 (en) | 1998-01-07 |
| ES2112870T3 (es) | 1998-04-16 |
| CA2062652A1 (en) | 1992-09-14 |
| TW201750B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-03-11 |
| JP2998287B2 (ja) | 2000-01-11 |
| DE69223827D1 (de) | 1998-02-12 |
| US5229378A (en) | 1993-07-20 |
| EP0503582A1 (en) | 1992-09-16 |
| KR920018062A (ko) | 1992-10-21 |
| DE69223827T2 (de) | 1998-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |