ATE156727T1 - Verfahren zur herstellung von wirkstoffe enthaltenden kügelchen - Google Patents

Verfahren zur herstellung von wirkstoffe enthaltenden kügelchen

Info

Publication number
ATE156727T1
ATE156727T1 AT94400650T AT94400650T ATE156727T1 AT E156727 T1 ATE156727 T1 AT E156727T1 AT 94400650 T AT94400650 T AT 94400650T AT 94400650 T AT94400650 T AT 94400650T AT E156727 T1 ATE156727 T1 AT E156727T1
Authority
AT
Austria
Prior art keywords
active ingredients
containing active
beads containing
producing beads
spherules
Prior art date
Application number
AT94400650T
Other languages
English (en)
Inventor
Jean-Marie Dollat
Marc Molin
Pascal Theallier
Original Assignee
Rhone Poulenc Nutrition Animal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Nutrition Animal filed Critical Rhone Poulenc Nutrition Animal
Application granted granted Critical
Publication of ATE156727T1 publication Critical patent/ATE156727T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Steroid Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Fats And Perfumes (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT94400650T 1993-03-31 1994-03-28 Verfahren zur herstellung von wirkstoffe enthaltenden kügelchen ATE156727T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9303728A FR2703263B1 (fr) 1993-03-31 1993-03-31 Procédé de préparation de sphérules de principes actifs.

Publications (1)

Publication Number Publication Date
ATE156727T1 true ATE156727T1 (de) 1997-08-15

Family

ID=9445550

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94400650T ATE156727T1 (de) 1993-03-31 1994-03-28 Verfahren zur herstellung von wirkstoffe enthaltenden kügelchen

Country Status (12)

Country Link
US (1) US5500415A (de)
EP (1) EP0618001B1 (de)
JP (1) JP2515487B2 (de)
AT (1) ATE156727T1 (de)
CA (1) CA2120290C (de)
DE (1) DE69404885T2 (de)
DK (1) DK0618001T3 (de)
ES (1) ES2105544T3 (de)
FR (1) FR2703263B1 (de)
GR (1) GR3024609T3 (de)
RU (1) RU2145211C1 (de)
UA (1) UA27801C2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT729353E (pt) * 1993-11-19 2002-07-31 Alkermes Inc Preparacao de microparticulas biodegradaveis contendo um agente biologicamente activo
EP0912238B1 (de) * 1996-07-15 2001-10-10 CalCiTech Ltd. Herstellung von pulvern
DE19642359A1 (de) * 1996-10-14 1998-04-16 Basf Ag Stabile Emulsionen und Trockenpulver von Mischungen fettlöslicher Vitamine, deren Herstellung und Verwendung
DE19838189A1 (de) * 1998-08-24 2000-03-02 Basf Ag Stabile pulverförmige Vitamin- und Carotinoid-Zubereitungen und Verfahren zu deren Herstellung
US6582721B1 (en) 1999-09-17 2003-06-24 Alcon, Inc. Stable carotene-xanthophyll beadlet compositions and methods of use
PT1244472E (pt) 1999-12-23 2005-09-30 Adisseo France Sas Composicao vitaminica em particulas
AU2001272489A1 (en) * 2000-05-31 2001-12-11 Aventis Animal Nutrition S.A. Granular vitamin composition
FR2836827B1 (fr) * 2002-03-07 2010-10-01 Innoform Sa Composition dietetique et cosmetique a base de polymeres naturels reticules immobilisant des actifs
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US20050186282A1 (en) * 2002-08-01 2005-08-25 The Regents Of The University Of California, A California Corporation Method and compositions for preparing and delivering lipids, other nutrients and medicaments
JP2005534317A (ja) * 2002-08-01 2005-11-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ルーメンで保護される脂質、他の栄養剤及び薬剤を調整並びに送達するための方法及び配合物
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP2009536313A (ja) 2006-01-11 2009-10-08 レインダンス テクノロジーズ， インコーポレイテッド ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
EP3736281A1 (de) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2714970B1 (de) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
CN104224542B (zh) * 2014-09-17 2017-03-01 河南农业大学 复方维生素口服液生产制备系统
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2828202A (en) * 1954-10-08 1958-03-25 Sintercast Corp America Titanium tool steel
BE602237A (de) * 1960-04-07
DK135654B (da) * 1966-07-30 1977-06-06 Sumitomo Chemical Co Fremgangsmåde til fremstilling af småkorn af vanduopløselige eller i det væsentlige vanduopløselige faste eller flydende stoffer.
FR1497584A (fr) * 1966-08-11 1967-10-13 Roussel Uclaf Procédé de fabrication de microcapsules
DK111832B (da) * 1966-12-01 1968-10-14 Ferrosan As Fremgangsmåde til fremstilling af koldtvandsdispersible præparater indeholdende fedtopløselige vitaminer i tør partikulær, hældbar form.
JPS5210427B2 (de) * 1972-07-19 1977-03-24
JPS5431085A (en) * 1977-08-12 1979-03-07 Ota Pharma Method of solidifying oily matter
CH642564A5 (de) * 1979-10-26 1984-04-30 Sulzer Ag Statische mischvorrichtung.
WO1984002255A2 (en) * 1982-12-06 1984-06-21 Hydrosyn Systems Inc Lipid pelletization methods, apparatus and products
CA1335748C (en) 1986-09-25 1995-05-30 Jeffrey Lawrence Finnan Crosslinked gelatins
ATE64527T1 (de) * 1987-04-06 1991-07-15 Hoffmann La Roche Verfahren zur herstellung von vitaminpraeparaten.
IL88961A (en) * 1988-01-29 1992-07-15 Basf Ag Stable mixtures containing oxidation-sensitive compounds
US5035896A (en) * 1988-06-15 1991-07-30 Warner-Lambert Company Water insoluble drugs coated by coacervated fish gelatin
JP3051945B2 (ja) * 1991-07-22 2000-06-12 大阪瓦斯株式会社 無機質均一微小球体、及びその製造方法

Also Published As

Publication number Publication date
CA2120290A1 (fr) 1994-10-01
RU2145211C1 (ru) 2000-02-10
DK0618001T3 (da) 1997-12-29
DE69404885D1 (de) 1997-09-18
RU94010892A (ru) 1996-08-10
CA2120290C (fr) 1999-04-20
JPH07489A (ja) 1995-01-06
GR3024609T3 (en) 1997-12-31
EP0618001B1 (de) 1997-08-13
FR2703263A1 (fr) 1994-10-07
US5500415A (en) 1996-03-19
ES2105544T3 (es) 1997-10-16
FR2703263B1 (fr) 1995-05-19
DE69404885T2 (de) 1998-01-22
EP0618001A1 (de) 1994-10-05
UA27801C2 (uk) 2000-10-16
JP2515487B2 (ja) 1996-07-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee