DK0618001T3 - Fremgangsmåde til fremstilling af små sfærer af aktive stoffer - Google Patents

Fremgangsmåde til fremstilling af små sfærer af aktive stoffer

Info

Publication number
DK0618001T3
DK0618001T3 DK94400650.1T DK94400650T DK0618001T3 DK 0618001 T3 DK0618001 T3 DK 0618001T3 DK 94400650 T DK94400650 T DK 94400650T DK 0618001 T3 DK0618001 T3 DK 0618001T3
Authority
DK
Denmark
Prior art keywords
preparation
active substances
small spheres
spherules
water
Prior art date
Application number
DK94400650.1T
Other languages
English (en)
Inventor
Jean-Marie Dollat
Marc Molin
Pascal Theallier
Original Assignee
Rhone Poulenc Nutrition Animal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Nutrition Animal filed Critical Rhone Poulenc Nutrition Animal
Application granted granted Critical
Publication of DK0618001T3 publication Critical patent/DK0618001T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Fats And Perfumes (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94400650.1T 1993-03-31 1994-03-28 Fremgangsmåde til fremstilling af små sfærer af aktive stoffer DK0618001T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9303728A FR2703263B1 (fr) 1993-03-31 1993-03-31 Procédé de préparation de sphérules de principes actifs.

Publications (1)

Publication Number Publication Date
DK0618001T3 true DK0618001T3 (da) 1997-12-29

Family

ID=9445550

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94400650.1T DK0618001T3 (da) 1993-03-31 1994-03-28 Fremgangsmåde til fremstilling af små sfærer af aktive stoffer

Country Status (12)

Country Link
US (1) US5500415A (da)
EP (1) EP0618001B1 (da)
JP (1) JP2515487B2 (da)
AT (1) ATE156727T1 (da)
CA (1) CA2120290C (da)
DE (1) DE69404885T2 (da)
DK (1) DK0618001T3 (da)
ES (1) ES2105544T3 (da)
FR (1) FR2703263B1 (da)
GR (1) GR3024609T3 (da)
RU (1) RU2145211C1 (da)
UA (1) UA27801C2 (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09505308A (ja) * 1993-11-19 1997-05-27 アルカーミズ・コントロールド・セラピューティクス・インコーポレイテッド・トゥー 生物学的活性剤を含有する生分解性微粒子の製造
US6458335B1 (en) * 1996-07-15 2002-10-01 Calcitech Ltd. Production of powders
DE19642359A1 (de) * 1996-10-14 1998-04-16 Basf Ag Stabile Emulsionen und Trockenpulver von Mischungen fettlöslicher Vitamine, deren Herstellung und Verwendung
DE19838189A1 (de) * 1998-08-24 2000-03-02 Basf Ag Stabile pulverförmige Vitamin- und Carotinoid-Zubereitungen und Verfahren zu deren Herstellung
US6582721B1 (en) 1999-09-17 2003-06-24 Alcon, Inc. Stable carotene-xanthophyll beadlet compositions and methods of use
KR100695646B1 (ko) * 1999-12-23 2007-03-15 아디쎄오 프랑스 에스에이에스 미립자 비타민 조성물
AU2001272489A1 (en) * 2000-05-31 2001-12-11 Aventis Animal Nutrition S.A. Granular vitamin composition
FR2836827B1 (fr) * 2002-03-07 2010-10-01 Innoform Sa Composition dietetique et cosmetique a base de polymeres naturels reticules immobilisant des actifs
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US20050186282A1 (en) * 2002-08-01 2005-08-25 The Regents Of The University Of California, A California Corporation Method and compositions for preparing and delivering lipids, other nutrients and medicaments
WO2004012520A2 (en) * 2002-08-01 2004-02-12 The Regents Of The University Of California Composite rumen delivery gels containing lipids, medicaments and nutrients
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
WO2008063227A2 (en) 2006-05-11 2008-05-29 Raindance Technologies, Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
CN104224542B (zh) * 2014-09-17 2017-03-01 河南农业大学 复方维生素口服液生产制备系统
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2828202A (en) * 1954-10-08 1958-03-25 Sintercast Corp America Titanium tool steel
NL250281A (da) * 1960-04-07
DK135654B (da) * 1966-07-30 1977-06-06 Sumitomo Chemical Co Fremgangsmåde til fremstilling af småkorn af vanduopløselige eller i det væsentlige vanduopløselige faste eller flydende stoffer.
FR1497584A (fr) * 1966-08-11 1967-10-13 Roussel Uclaf Procédé de fabrication de microcapsules
DK111832B (da) * 1966-12-01 1968-10-14 Ferrosan As Fremgangsmåde til fremstilling af koldtvandsdispersible præparater indeholdende fedtopløselige vitaminer i tør partikulær, hældbar form.
JPS5210427B2 (da) * 1972-07-19 1977-03-24
JPS5431085A (en) * 1977-08-12 1979-03-07 Ota Pharma Method of solidifying oily matter
CH642564A5 (de) * 1979-10-26 1984-04-30 Sulzer Ag Statische mischvorrichtung.
WO1984002255A2 (en) * 1982-12-06 1984-06-21 Hydrosyn Systems Inc Lipid pelletization methods, apparatus and products
EP0285682B2 (en) * 1987-04-06 1997-08-06 F. Hoffmann-La Roche Ag Process for the manufacture of vitamin preparations
CA1335748C (en) 1986-09-25 1995-05-30 Jeffrey Lawrence Finnan Crosslinked gelatins
IL88961A (en) * 1988-01-29 1992-07-15 Basf Ag Stable mixtures containing oxidation-sensitive compounds
US5035896A (en) * 1988-06-15 1991-07-30 Warner-Lambert Company Water insoluble drugs coated by coacervated fish gelatin
JP3051945B2 (ja) * 1991-07-22 2000-06-12 大阪瓦斯株式会社 無機質均一微小球体、及びその製造方法

Also Published As

Publication number Publication date
RU94010892A (ru) 1996-08-10
FR2703263B1 (fr) 1995-05-19
ES2105544T3 (es) 1997-10-16
ATE156727T1 (de) 1997-08-15
EP0618001B1 (fr) 1997-08-13
DE69404885D1 (de) 1997-09-18
UA27801C2 (uk) 2000-10-16
JP2515487B2 (ja) 1996-07-10
JPH07489A (ja) 1995-01-06
GR3024609T3 (en) 1997-12-31
FR2703263A1 (fr) 1994-10-07
EP0618001A1 (fr) 1994-10-05
DE69404885T2 (de) 1998-01-22
CA2120290C (fr) 1999-04-20
US5500415A (en) 1996-03-19
RU2145211C1 (ru) 2000-02-10
CA2120290A1 (fr) 1994-10-01

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