ATE156522T1 - Neue oligonukleotide konjugiert zu lanthanide- chelaten - Google Patents
Neue oligonukleotide konjugiert zu lanthanide- chelatenInfo
- Publication number
- ATE156522T1 ATE156522T1 AT92907537T AT92907537T ATE156522T1 AT E156522 T1 ATE156522 T1 AT E156522T1 AT 92907537 T AT92907537 T AT 92907537T AT 92907537 T AT92907537 T AT 92907537T AT E156522 T1 ATE156522 T1 AT E156522T1
- Authority
- AT
- Austria
- Prior art keywords
- chelate
- rare earth
- lanthanide chelates
- oligonucleotides conjugated
- new oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052747 lanthanoid Inorganic materials 0.000 title 1
- 150000002602 lanthanoids Chemical class 0.000 title 1
- 239000013522 chelant Substances 0.000 abstract 2
- 229910052761 rare earth metal Inorganic materials 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 238000007899 nucleic acid hybridization Methods 0.000 abstract 1
- 150000002910 rare earth metals Chemical class 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000001685 time-resolved fluorescence spectroscopy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/40—Rare earth chelates
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65570791A | 1991-02-14 | 1991-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE156522T1 true ATE156522T1 (de) | 1997-08-15 |
Family
ID=24630035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92907537T ATE156522T1 (de) | 1991-02-14 | 1992-02-10 | Neue oligonukleotide konjugiert zu lanthanide- chelaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5955601A (de) |
| EP (1) | EP0525181B1 (de) |
| JP (1) | JPH05505201A (de) |
| AT (1) | ATE156522T1 (de) |
| AU (1) | AU653012B2 (de) |
| CA (1) | CA2079448C (de) |
| DE (1) | DE69221404T2 (de) |
| ES (1) | ES2108109T3 (de) |
| WO (1) | WO1992014841A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2284208A (en) * | 1993-11-25 | 1995-05-31 | Pna Diagnostics As | Nucleic acid analogues with a chelating functionality for metal ions |
| IL114235A0 (en) * | 1994-07-14 | 1995-10-31 | Schering Ag | Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same |
| WO1998000435A2 (en) * | 1996-07-03 | 1998-01-08 | President And Fellows Of Harvard College | Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| FR2769315B1 (fr) * | 1997-10-03 | 2001-06-08 | Cis Bio Int | Conjugues fluorescents de nucleosides ou de nucleotides, leur procede de preparation et leur utilisation |
| DE10018465A1 (de) * | 2000-04-14 | 2001-10-18 | Aventis Res & Tech Gmbh & Co | Testsystem zum Nachweis einer Spleißreaktion, sowie dessen Verwendung |
| US7906343B2 (en) * | 2005-01-24 | 2011-03-15 | Sri International | Surface-enhanced lanthanide chelates |
| EP2052252B1 (de) | 2006-08-18 | 2010-11-10 | Abacus Diagnostica OY | Lumineszierende lanthanid-markierungsreagentien und deren verwendung |
| US20080269065A1 (en) * | 2007-04-30 | 2008-10-30 | Syntrix Biosystems, Inc. | Conformationally Constrained Analytical Probes |
| JP5606435B2 (ja) | 2008-07-16 | 2014-10-15 | ラジオメーター・メディカル・アー・ペー・エス | トロンビン基質およびサンプル中の生体活性トロンビンのレベルを測定するためのアッセイ |
| EP2363502B1 (de) | 2010-03-04 | 2017-02-15 | miacom Diagnostics GmbH | Verbessertes Multiplex-FISH |
| DK2825309T3 (en) | 2012-03-16 | 2018-07-30 | Stat Diagnostica & Innovation Sl | Sample cartridge with integrated transfer module |
| WO2014031902A2 (en) | 2012-08-23 | 2014-02-27 | The Regents Of The University Of California | Spectrally encoded microbeads and methods and devices for making and using same |
| KR101918352B1 (ko) * | 2016-09-30 | 2018-11-14 | 현대자동차주식회사 | 라이트가이드가 구비된 차량용 광원 모듈 |
| CN114062328A (zh) * | 2020-08-10 | 2022-02-18 | 深圳先进技术研究院 | 一种基于核酸杂交增强稀土配合物荧光的检测方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4058732A (en) * | 1975-06-30 | 1977-11-15 | Analytical Radiation Corporation | Method and apparatus for improved analytical fluorescent spectroscopy |
| US4150295A (en) * | 1978-01-05 | 1979-04-17 | Analytical Radiation Corporation | Method and apparatus for background correction in photoluminescent analysis |
| FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
| SE8301395L (sv) * | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
| US4761481A (en) * | 1985-03-18 | 1988-08-02 | Baxter Travenol Laboratories, Inc. | Substituted pyridine derivatives |
| SE454781B (sv) * | 1986-10-17 | 1988-05-30 | Wallac Oy | Hybridiseringsforfarande for detektion av polynukleotidsekvens |
| SE8703682L (sv) * | 1987-09-24 | 1989-03-25 | Wallac Oy | Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner |
| AU2714988A (en) * | 1987-10-23 | 1989-06-01 | Siska Diagnostics, Inc. | Lanthanide chelate-tagged nucleic acid probes |
| US5032677A (en) * | 1987-11-06 | 1991-07-16 | Baxter International Inc. | Fluorescent poly(arylpyridine) rare earth chelates |
| SE8802573D0 (sv) * | 1988-07-08 | 1988-07-08 | Wallac Oy | Multi-label time-resolved fluorescence analysis of nucleic acid sequences using lanthanide chelates |
| SE8802575D0 (sv) * | 1988-07-08 | 1988-07-08 | Wallac Oy | Terpyridine derivatives |
-
1992
- 1992-02-10 ES ES92907537T patent/ES2108109T3/es not_active Expired - Lifetime
- 1992-02-10 EP EP92907537A patent/EP0525181B1/de not_active Expired - Lifetime
- 1992-02-10 AT AT92907537T patent/ATE156522T1/de not_active IP Right Cessation
- 1992-02-10 DE DE69221404T patent/DE69221404T2/de not_active Expired - Fee Related
- 1992-02-10 CA CA002079448A patent/CA2079448C/en not_active Expired - Fee Related
- 1992-02-10 AU AU14507/92A patent/AU653012B2/en not_active Ceased
- 1992-02-10 JP JP4507052A patent/JPH05505201A/ja not_active Withdrawn
- 1992-02-10 WO PCT/US1992/001149 patent/WO1992014841A1/en active IP Right Grant
-
1997
- 1997-03-05 US US08/811,478 patent/US5955601A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0657717B1 (de) | 1994-08-03 |
| DE69221404T2 (de) | 1998-02-05 |
| US5955601A (en) | 1999-09-21 |
| DE69221404D1 (de) | 1997-09-11 |
| ES2108109T3 (es) | 1997-12-16 |
| EP0525181A1 (de) | 1993-02-03 |
| CA2079448C (en) | 2000-05-23 |
| EP0525181A4 (en) | 1993-03-10 |
| EP0525181B1 (de) | 1997-08-06 |
| WO1992014841A1 (en) | 1992-09-03 |
| AU653012B2 (en) | 1994-09-15 |
| CA2079448A1 (en) | 1992-08-15 |
| JPH05505201A (ja) | 1993-08-05 |
| AU1450792A (en) | 1992-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE156522T1 (de) | Neue oligonukleotide konjugiert zu lanthanide- chelaten | |
| EP1281964A3 (de) | Anordnung und Verfahren zur Mehrfach-Fluoreszenzmessung | |
| FI953259A (fi) | Korkeita lämpötiloja kestävä hapetuskatalyytti, menetelmä sen valmistamiseksi sekä tällaista katalyyttiä käyttävä polttomenetelmä | |
| ATE270298T1 (de) | Reaktionssystem und verfahren zur verstärkung der lumineszenz von makrocyclischen lanthanid(iii)- komplexen | |
| Otis et al. | The identification of channel three in isolated benzene | |
| Chen et al. | Lifetime-and color-tailored fluorophores in the micro-to millisecond time regime | |
| KR950032641A (ko) | 형광 염료를 사용한 이본쇄 핵산의 동질 분석법 및 이에 유용한 키트 | |
| EP0670041A4 (de) | Fluoreszenzenergieübertragung und intramolekulare energieübertragung in teilchen unter verwendung neuer verbindungen. | |
| DK1218545T3 (da) | Fremgangsmåder til fremstilling af oligonukleotidopløsninger | |
| CA2256457A1 (en) | Passive internal references for the detection of nucleic acid amplification products | |
| DE68927886D1 (de) | Terpyridin-derivate | |
| DE69723111D1 (de) | Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung | |
| ATE156592T1 (de) | Verfahren zum nachweis von substanzen | |
| WO2001053527A1 (fr) | Procede de detection d'adn par procede d'hybridation d'adn, a l'aide d'un transfert d'energie de resonance fluorescente | |
| EP1106621A3 (de) | Fluoreszente materialen | |
| SE8801011D0 (sv) | Time-resolved electroluminescence in solution | |
| ES2187800T3 (es) | Reactivos formadores de complejos con compuestos boronicos y complejos correspondientes. | |
| BRPI0414987A (pt) | ensaio aperfeiçoado homogêneo de transferência de energia com resolução no tempo | |
| PT1119528E (pt) | Construtor quimicos e seus usos | |
| ATE338283T1 (de) | Strahlungsidentifizierung mit hilfe eines proportionalgaszählers | |
| Kazakov et al. | Application of a synchronous integrator in phase fluorometry | |
| Wehry | Molecular luminescence methods | |
| Chambers | Piano quintet I | |
| Morgan et al. | A generalized Laplace formula | |
| Maroulis et al. | Quenching of the charge transfer luminescence of tris (2, 2′-bipyridine) Ru (II) by Co (III) ketoenolates |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |