DE69221404D1 - Neue oligonukleotide konjugiert zu lanthanide-chelaten - Google Patents
Neue oligonukleotide konjugiert zu lanthanide-chelatenInfo
- Publication number
- DE69221404D1 DE69221404D1 DE69221404T DE69221404T DE69221404D1 DE 69221404 D1 DE69221404 D1 DE 69221404D1 DE 69221404 T DE69221404 T DE 69221404T DE 69221404 T DE69221404 T DE 69221404T DE 69221404 D1 DE69221404 D1 DE 69221404D1
- Authority
- DE
- Germany
- Prior art keywords
- chelate
- conjugated
- oligonucleotids
- new
- rare earth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229910052747 lanthanoid Inorganic materials 0.000 title 1
- 150000002602 lanthanoids Chemical class 0.000 title 1
- 239000013522 chelant Substances 0.000 abstract 2
- 229910052761 rare earth metal Inorganic materials 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 238000007899 nucleic acid hybridization Methods 0.000 abstract 1
- 150000002910 rare earth metals Chemical class 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000001685 time-resolved fluorescence spectroscopy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/40—Rare earth chelates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65570791A | 1991-02-14 | 1991-02-14 | |
| PCT/US1992/001149 WO1992014841A1 (en) | 1991-02-14 | 1992-02-10 | Novel lanthanide chelate-conjugated oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69221404D1 true DE69221404D1 (de) | 1997-09-11 |
| DE69221404T2 DE69221404T2 (de) | 1998-02-05 |
Family
ID=24630035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69221404T Expired - Fee Related DE69221404T2 (de) | 1991-02-14 | 1992-02-10 | Neue oligonukleotide konjugiert zu lanthanide-chelaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5955601A (de) |
| EP (1) | EP0525181B1 (de) |
| JP (1) | JPH05505201A (de) |
| AT (1) | ATE156522T1 (de) |
| AU (1) | AU653012B2 (de) |
| CA (1) | CA2079448C (de) |
| DE (1) | DE69221404T2 (de) |
| ES (1) | ES2108109T3 (de) |
| WO (1) | WO1992014841A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2284208A (en) * | 1993-11-25 | 1995-05-31 | Pna Diagnostics As | Nucleic acid analogues with a chelating functionality for metal ions |
| IL114235A0 (en) * | 1994-07-14 | 1995-10-31 | Schering Ag | Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same |
| EP0917533A2 (de) * | 1996-07-03 | 1999-05-26 | President And Fellows Of Harvard College | Oligonukleotid-linker und immobilisierte und verknüpfte oligonukleotide verwendendes verfahren |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| FR2769315B1 (fr) * | 1997-10-03 | 2001-06-08 | Cis Bio Int | Conjugues fluorescents de nucleosides ou de nucleotides, leur procede de preparation et leur utilisation |
| DE10018465A1 (de) * | 2000-04-14 | 2001-10-18 | Aventis Res & Tech Gmbh & Co | Testsystem zum Nachweis einer Spleißreaktion, sowie dessen Verwendung |
| WO2007084141A2 (en) * | 2005-01-24 | 2007-07-26 | Sri International | Surface-enhanced lanthanide chelates |
| JP5237949B2 (ja) | 2006-08-18 | 2013-07-17 | アバクス ディアグノスティカ オイ | 発光性ランタノイド標識試薬及びその用途 |
| US20080269065A1 (en) * | 2007-04-30 | 2008-10-30 | Syntrix Biosystems, Inc. | Conformationally Constrained Analytical Probes |
| EP2316035A2 (de) | 2008-07-16 | 2011-05-04 | Radiometer Medical ApS | Thrombinsubstrat und testverfahren zur bestimmung des spiegels von biologisch aktivem thrombin in einer probe |
| ES2623859T3 (es) | 2010-03-04 | 2017-07-12 | Miacom Diagnostics Gmbh | FISH múltiple mejorada |
| ES2682281T3 (es) | 2012-03-16 | 2018-09-19 | Stat-Diagnostica & Innovation, S.L. | Cartucho de prueba con módulo de transferencia integrado |
| EP2888392B1 (de) | 2012-08-23 | 2017-10-11 | The Regents of The University of California | Spektralcodierte mikrokugeln sowie verfahren und vorrichtungen zu ihrer herstellung und verwendung |
| KR101918352B1 (ko) * | 2016-09-30 | 2018-11-14 | 현대자동차주식회사 | 라이트가이드가 구비된 차량용 광원 모듈 |
| CN114062328A (zh) * | 2020-08-10 | 2022-02-18 | 深圳先进技术研究院 | 一种基于核酸杂交增强稀土配合物荧光的检测方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4058732A (en) * | 1975-06-30 | 1977-11-15 | Analytical Radiation Corporation | Method and apparatus for improved analytical fluorescent spectroscopy |
| US4150295A (en) * | 1978-01-05 | 1979-04-17 | Analytical Radiation Corporation | Method and apparatus for background correction in photoluminescent analysis |
| FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
| SE8301395L (sv) * | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
| US4761481A (en) * | 1985-03-18 | 1988-08-02 | Baxter Travenol Laboratories, Inc. | Substituted pyridine derivatives |
| SE454781B (sv) * | 1986-10-17 | 1988-05-30 | Wallac Oy | Hybridiseringsforfarande for detektion av polynukleotidsekvens |
| SE8703682L (sv) * | 1987-09-24 | 1989-03-25 | Wallac Oy | Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner |
| WO1989004375A1 (en) * | 1987-10-23 | 1989-05-18 | Siska Diagnostics, Inc. | Lanthanide chelate-tagged nucleic acid probes |
| US5032677A (en) * | 1987-11-06 | 1991-07-16 | Baxter International Inc. | Fluorescent poly(arylpyridine) rare earth chelates |
| SE8802575D0 (sv) * | 1988-07-08 | 1988-07-08 | Wallac Oy | Terpyridine derivatives |
| SE8802573D0 (sv) * | 1988-07-08 | 1988-07-08 | Wallac Oy | Multi-label time-resolved fluorescence analysis of nucleic acid sequences using lanthanide chelates |
-
1992
- 1992-02-10 AT AT92907537T patent/ATE156522T1/de not_active IP Right Cessation
- 1992-02-10 CA CA002079448A patent/CA2079448C/en not_active Expired - Fee Related
- 1992-02-10 WO PCT/US1992/001149 patent/WO1992014841A1/en active IP Right Grant
- 1992-02-10 AU AU14507/92A patent/AU653012B2/en not_active Ceased
- 1992-02-10 EP EP92907537A patent/EP0525181B1/de not_active Expired - Lifetime
- 1992-02-10 DE DE69221404T patent/DE69221404T2/de not_active Expired - Fee Related
- 1992-02-10 ES ES92907537T patent/ES2108109T3/es not_active Expired - Lifetime
- 1992-02-10 JP JP4507052A patent/JPH05505201A/ja not_active Withdrawn
-
1997
- 1997-03-05 US US08/811,478 patent/US5955601A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE156522T1 (de) | 1997-08-15 |
| JPH0657717B1 (de) | 1994-08-03 |
| AU653012B2 (en) | 1994-09-15 |
| EP0525181A4 (en) | 1993-03-10 |
| CA2079448C (en) | 2000-05-23 |
| EP0525181A1 (de) | 1993-02-03 |
| ES2108109T3 (es) | 1997-12-16 |
| JPH05505201A (ja) | 1993-08-05 |
| CA2079448A1 (en) | 1992-08-15 |
| DE69221404T2 (de) | 1998-02-05 |
| US5955601A (en) | 1999-09-21 |
| EP0525181B1 (de) | 1997-08-06 |
| WO1992014841A1 (en) | 1992-09-03 |
| AU1450792A (en) | 1992-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |