ATE153652T1 - Isocarbacyclin mit modifizierter alpha(a)-kette und verfahren zu dessen herstellung - Google Patents
Isocarbacyclin mit modifizierter alpha(a)-kette und verfahren zu dessen herstellungInfo
- Publication number
- ATE153652T1 ATE153652T1 AT93921098T AT93921098T ATE153652T1 AT E153652 T1 ATE153652 T1 AT E153652T1 AT 93921098 T AT93921098 T AT 93921098T AT 93921098 T AT93921098 T AT 93921098T AT E153652 T1 ATE153652 T1 AT E153652T1
- Authority
- AT
- Austria
- Prior art keywords
- chain
- isocarbacycline
- production
- modified alpha
- alpha
- Prior art date
Links
- JANVYOZZTKSZGN-WCAFQOMDSA-N 5-[(3as,5r,6r,6as)-5-hydroxy-6-[(e,3s)-3-hydroxyoct-1-enyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl]pentanoic acid Chemical compound C1=C(CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 JANVYOZZTKSZGN-WCAFQOMDSA-N 0.000 abstract 1
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- 206010072810 Vascular wall hypertrophy Diseases 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000043827 human Smooth muscle Human genes 0.000 abstract 1
- 108700038605 human Smooth muscle Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- -1 thiophenediyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/35—Unsaturated compounds having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26608492 | 1992-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE153652T1 true ATE153652T1 (de) | 1997-06-15 |
Family
ID=17426122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93921098T ATE153652T1 (de) | 1992-10-05 | 1993-10-01 | Isocarbacyclin mit modifizierter alpha(a)-kette und verfahren zu dessen herstellung |
Country Status (7)
Country | Link |
---|---|
US (1) | US5532408A (de) |
EP (1) | EP0664281B1 (de) |
KR (1) | KR100199124B1 (de) |
AT (1) | ATE153652T1 (de) |
CA (1) | CA2146361A1 (de) |
DE (1) | DE69311126T2 (de) |
WO (1) | WO1994007838A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996004903A1 (fr) * | 1994-08-09 | 1996-02-22 | Teijin Limited | Inhibiteur de la migration cellulaire dans les muscles lisses vasculaires |
EP4419519A1 (de) * | 2021-10-20 | 2024-08-28 | Assembly Biosciences, Inc. | Verfahren |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4338457A (en) * | 1980-02-28 | 1982-07-06 | The Upjohn Company | Composition and process |
HU190007B (en) * | 1982-05-06 | 1986-08-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing new aromatic prostacylin analogues |
JPS62258330A (ja) * | 1986-05-01 | 1987-11-10 | Teijin Ltd | 6,7−二置換−2−ヒドロキシ−3−メチレンビシクロ〔3.3.0〕オクタン類の製造法 |
JPH0645575B2 (ja) * | 1987-06-04 | 1994-06-15 | 帝人株式会社 | 3―メチレン―2,6,7―三置換ビシクロ[3.3.0オクタン類 |
JP3178150B2 (ja) * | 1993-03-12 | 2001-06-18 | 宇部興産株式会社 | 採血装置 |
-
1993
- 1993-10-01 EP EP93921098A patent/EP0664281B1/de not_active Expired - Lifetime
- 1993-10-01 KR KR1019950701298A patent/KR100199124B1/ko not_active IP Right Cessation
- 1993-10-01 WO PCT/JP1993/001407 patent/WO1994007838A1/ja active IP Right Grant
- 1993-10-01 AT AT93921098T patent/ATE153652T1/de not_active IP Right Cessation
- 1993-10-01 CA CA002146361A patent/CA2146361A1/en not_active Abandoned
- 1993-10-01 US US08/411,649 patent/US5532408A/en not_active Expired - Fee Related
- 1993-10-01 DE DE69311126T patent/DE69311126T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1994007838A1 (en) | 1994-04-14 |
EP0664281A1 (de) | 1995-07-26 |
EP0664281B1 (de) | 1997-05-28 |
DE69311126D1 (de) | 1997-07-03 |
DE69311126T2 (de) | 1997-11-06 |
KR100199124B1 (ko) | 1999-06-15 |
KR950703511A (ko) | 1995-09-20 |
CA2146361A1 (en) | 1994-04-14 |
EP0664281A4 (de) | 1995-08-16 |
US5532408A (en) | 1996-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |