ATE139697T1 - Macrozyklische laktam-prokinetika - Google Patents

Macrozyklische laktam-prokinetika

Info

Publication number
ATE139697T1
ATE139697T1 AT92911585T AT92911585T ATE139697T1 AT E139697 T1 ATE139697 T1 AT E139697T1 AT 92911585 T AT92911585 T AT 92911585T AT 92911585 T AT92911585 T AT 92911585T AT E139697 T1 ATE139697 T1 AT E139697T1
Authority
AT
Austria
Prior art keywords
image
pct
prokinetics
sec
macrocyclic lactam
Prior art date
Application number
AT92911585T
Other languages
German (de)
English (en)
Inventor
Leslie A Freiberg
Carla Edwards
Richard J Pariza
Hugh N Nellans
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE139697T1 publication Critical patent/ATE139697T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT92911585T 1991-04-09 1992-03-30 Macrozyklische laktam-prokinetika ATE139697T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68283691A 1991-04-09 1991-04-09

Publications (1)

Publication Number Publication Date
ATE139697T1 true ATE139697T1 (de) 1996-07-15

Family

ID=24741372

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92911585T ATE139697T1 (de) 1991-04-09 1992-03-30 Macrozyklische laktam-prokinetika

Country Status (15)

Country Link
US (1) US5538961A (enExample)
EP (1) EP0579770B1 (enExample)
JP (1) JPH06509326A (enExample)
KR (1) KR100222014B1 (enExample)
AT (1) ATE139697T1 (enExample)
AU (1) AU663089B2 (enExample)
CA (1) CA2103913A1 (enExample)
DE (1) DE69211845T2 (enExample)
DK (1) DK0579770T3 (enExample)
ES (1) ES2091471T3 (enExample)
GR (1) GR3020853T3 (enExample)
IE (1) IE73236B1 (enExample)
IL (1) IL101504A (enExample)
PT (1) PT100357B (enExample)
WO (1) WO1992018134A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1122261A3 (en) * 2000-01-31 2001-09-26 Pfizer Products Inc. 13 and 14-membered antibacterial macrolides
JP2003523347A (ja) 2000-02-18 2003-08-05 コーサン バイオサイエンシーズ， インコーポレイテッド モチライド化合物
US6734292B1 (en) 2000-08-17 2004-05-11 The Kitasato Institute Pseudoerythromycin derivatives
AU2002225724A1 (en) * 2000-12-01 2002-07-08 Kosan Biosciences, Inc. Motilide compounds
US20020094962A1 (en) * 2000-12-01 2002-07-18 Gary Ashley Motilide compounds
CN100363359C (zh) * 2002-08-29 2008-01-23 菲塞股份有限公司 运动内酯化合物
CA2498507A1 (en) * 2002-09-12 2004-03-25 Eli D. Ehrenpreis Monitoring and diagnosis of gastric emptying and gastroparesis
ATE457995T1 (de) 2003-06-18 2010-03-15 Tranzyme Pharma Inc Makrozyklische motilin rezeptorantagonisten
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US7582611B2 (en) 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
EP1960414A4 (en) * 2005-12-08 2008-12-17 Pfizer Method for demethylating the 3'-dimethylamino group of erythromycin compounds
EP2054429B1 (en) 2006-09-11 2013-11-06 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
WO2008068593A2 (en) * 2006-12-05 2008-06-12 Pfizer Inc. Motilide polymorphs
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
CN107254539A (zh) * 2011-07-29 2017-10-17 剑桥表现遗传学有限公司 用于检测核苷酸修饰的方法
US10563248B2 (en) 2012-11-30 2020-02-18 Cambridge Epigenetix Limited Oxidizing agent for modified nucleotides
CN115057794B (zh) * 2022-07-07 2023-11-17 桂林理工大学 一种可见光诱导铈催化氧化酰胺去甲基化的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518590A (en) * 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
EP0215355B1 (en) * 1985-08-31 1994-04-06 Kitasato Kenkyusho Erythromycin derivative and process for preparing the same
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US4958010A (en) * 1988-02-16 1990-09-18 Bristol-Myers Company Epipodophyllotoxin glucoside lactam derivatives
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers

Also Published As

Publication number Publication date
IE921045A1 (en) 1992-10-21
DE69211845T2 (de) 1997-01-23
DK0579770T3 (da) 1996-11-04
KR100222014B1 (ko) 1999-10-01
ES2091471T3 (es) 1996-11-01
IL101504A (en) 1998-04-05
EP0579770A1 (en) 1994-01-26
JPH06509326A (ja) 1994-10-20
EP0579770B1 (en) 1996-06-26
GR3020853T3 (en) 1996-11-30
WO1992018134A1 (en) 1992-10-29
CA2103913A1 (en) 1992-10-10
DE69211845D1 (de) 1996-08-01
PT100357A (pt) 1993-07-30
AU663089B2 (en) 1995-09-28
US5538961A (en) 1996-07-23
AU1910392A (en) 1992-11-17
IE73236B1 (en) 1997-05-21
IL101504A0 (en) 1992-12-30
EP0579770A4 (enExample) 1994-03-30
PT100357B (pt) 1999-06-30

Similar Documents

Publication Publication Date Title
ATE139697T1 (de) Macrozyklische laktam-prokinetika
BR9408246A (pt) Composto derivado de 3-azabicicloalcano N-substituído
HUT66660A (en) Intermediates for producing 9-[(substituted glicyl)-amido]-6-demetyl-6-deoxy-tetracyclines and pharmaceutical compositions containing them
IL99775A0 (en) Antimicrobial agents containing substituted 2-cyclohexan-1-yl-amino derivatives,certain such novel compounds and their preparation
IL98933A0 (en) Benzimidazoles,their preparation and pharmaceutical compositions containing them
HUT51864A (enExample)
ZA942131B (en) Pyridothiadiazines processes for their preparation and the pharmaceutical compositions which contain them
ZA914133B (en) Preparation of substituted piperidines
BR9206823A (pt) Preparação de piperidinas substituídas
DE3667059D1 (en) Benzodipyrroles, processes for their preparation and pharmaceutical compositions containing these compounds
EP0450420A3 (en) Dihydropyridines substituted by heterocycles, process for their preparation and their use in medicaments
DK0564358T3 (da) 3-aminochroman-spiro-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne
DK0484966T3 (da) 7-Acryl-3-(substitueret carbamoyloxy)cephemforbindelser, anvendelse deraf og fremgangsmåde deraf
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
SE9203824D0 (sv) Benzofuranylimidazole derivatives a process for the preparation and therapeutical compositions containing the same
US5162542A (en) Substituted pyrazoline derivatives
GR3015706T3 (en) Benzylselenobenzamides of aminopyridines and picolylamines.
DK0552631T3 (da) Alfa-Aryl-alfa-hydroxy-beta-imidazolinyl-propionsyreamider
IL101379A0 (en) Light screening compositions containing isoxazolones,certain such novel compounds and their preparation
GR3015592T3 (en) Pharmaceuticals containing substituted cyclohex-2-en-1-yl-amine derivatives and their use in combatting diseases.
IL97780A0 (en) Substituted 3-thia-and 3-oxa-alkylflavones,a process for their preparation,the use thereof,medicaments based on these compounds and intermediates
MY110894A (en) New pyrazolylpryrazoles, processes for their preparation, as well as intermediates, and thier use as herbicides
GR3029453T3 (en) NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee