ATE137752T1 - 5-aminocarbonyl-5h-dibenzo-a,d>cyclohepten-5,10 imine zur behandlung von epilepsie und kokainsucht - Google Patents

5-aminocarbonyl-5h-dibenzo-a,d>cyclohepten-5,10 imine zur behandlung von epilepsie und kokainsucht

Info

Publication number
ATE137752T1
ATE137752T1 AT90905307T AT90905307T ATE137752T1 AT E137752 T1 ATE137752 T1 AT E137752T1 AT 90905307 T AT90905307 T AT 90905307T AT 90905307 T AT90905307 T AT 90905307T AT E137752 T1 ATE137752 T1 AT E137752T1
Authority
AT
Austria
Prior art keywords
treatment
epilepsy
cyclohepten
dibenzo
aminocarbonyl
Prior art date
Application number
AT90905307T
Other languages
English (en)
Inventor
James A Monn
Andrew Thurkauf
Shunichi Yamaguchi
Michael A Rogawski
Kenneth C Rice
Mariena V Mattson
Arthur E Jacobson
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE137752T1 publication Critical patent/ATE137752T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT90905307T 1989-05-09 1990-03-23 5-aminocarbonyl-5h-dibenzo-a,d>cyclohepten-5,10 imine zur behandlung von epilepsie und kokainsucht ATE137752T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34918789A 1989-05-09 1989-05-09

Publications (1)

Publication Number Publication Date
ATE137752T1 true ATE137752T1 (de) 1996-05-15

Family

ID=23371261

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90905307T ATE137752T1 (de) 1989-05-09 1990-03-23 5-aminocarbonyl-5h-dibenzo-a,d>cyclohepten-5,10 imine zur behandlung von epilepsie und kokainsucht

Country Status (9)

Country Link
EP (1) EP0472526B1 (de)
JP (2) JPH07119224B2 (de)
AT (1) ATE137752T1 (de)
AU (1) AU637364B2 (de)
CA (1) CA2053247C (de)
DE (1) DE69026936T2 (de)
DK (1) DK0472526T3 (de)
ES (1) ES2091820T3 (de)
WO (1) WO1990013297A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025203A1 (en) * 1992-06-17 1993-12-23 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method of treating and protecting against central nervous system ischemia, hypoxia, degeneration, and trauma with a 5-aminocarbonyl-sh-dibenzo[a,d]cyclohepten-5,10-imine
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
AU6765598A (en) * 1997-03-20 1998-10-12 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo(3.2.1.) octanes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
US4399141A (en) * 1977-09-19 1983-08-16 Merck & Co., Inc. 5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof
NZ221626A (en) * 1986-09-08 1989-11-28 Merck & Co Inc Dibenzo(a,d cycloheptene derivatives and pharmaceutical compositions
NZ225634A (en) * 1987-08-10 1991-03-26 Merck & Co Inc 10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
JPH04503216A (ja) 1992-06-11
ES2091820T3 (es) 1996-11-16
EP0472526A4 (en) 1992-05-20
JPH08157474A (ja) 1996-06-18
WO1990013297A1 (en) 1990-11-15
JP2798628B2 (ja) 1998-09-17
EP0472526B1 (de) 1996-05-08
JPH07119224B2 (ja) 1995-12-20
AU5339690A (en) 1990-11-29
CA2053247A1 (en) 1990-11-10
DE69026936D1 (de) 1996-06-13
CA2053247C (en) 1996-01-02
DE69026936T2 (de) 1997-01-16
AU637364B2 (en) 1993-05-27
DK0472526T3 (da) 1996-07-29
EP0472526A1 (de) 1992-03-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee