ATE114719T1 - Dna-sequenz, beteiligt an der regulation der expression einer dna-sequenz, die einen polypeptid-precursor kodiert, expressionsvektoren und methode der periplasmatischen herstellung des polypeptides. - Google Patents

Dna-sequenz, beteiligt an der regulation der expression einer dna-sequenz, die einen polypeptid-precursor kodiert, expressionsvektoren und methode der periplasmatischen herstellung des polypeptides.

Info

Publication number
ATE114719T1
ATE114719T1 AT89402329T AT89402329T ATE114719T1 AT E114719 T1 ATE114719 T1 AT E114719T1 AT 89402329 T AT89402329 T AT 89402329T AT 89402329 T AT89402329 T AT 89402329T AT E114719 T1 ATE114719 T1 AT E114719T1
Authority
AT
Austria
Prior art keywords
dna sequence
polypeptide
expression
regulation
sequence encoding
Prior art date
Application number
AT89402329T
Other languages
English (en)
Inventor
Richard Legoux
Pascal Leplatois
Evelyne Joseph-Liauzun
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE114719T1 publication Critical patent/ATE114719T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT89402329T 1988-08-24 1989-08-23 Dna-sequenz, beteiligt an der regulation der expression einer dna-sequenz, die einen polypeptid-precursor kodiert, expressionsvektoren und methode der periplasmatischen herstellung des polypeptides. ATE114719T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8811187A FR2636644B1 (fr) 1988-08-24 1988-08-24 Sequence d'adn participant a la regulation de l'expression d'une sequence d'adn codant pour un precurseur d'un polypeptide, vecteurs d'expression et procede de production periplasmique du polypeptide

Publications (1)

Publication Number Publication Date
ATE114719T1 true ATE114719T1 (de) 1994-12-15

Family

ID=9369497

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89402329T ATE114719T1 (de) 1988-08-24 1989-08-23 Dna-sequenz, beteiligt an der regulation der expression einer dna-sequenz, die einen polypeptid-precursor kodiert, expressionsvektoren und methode der periplasmatischen herstellung des polypeptides.

Country Status (9)

Country Link
EP (1) EP0360641B1 (de)
JP (1) JP2662044B2 (de)
AT (1) ATE114719T1 (de)
CA (1) CA1337180C (de)
DE (1) DE68919619T2 (de)
ES (1) ES2066008T3 (de)
FR (1) FR2636644B1 (de)
GR (1) GR3014930T3 (de)
PT (1) PT91510B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2729972B1 (fr) * 1995-01-31 1997-04-18 Sanofi Sa Procede d'extraction de proteines periplasmiques de microorganismes procaryotes en presence d'arginine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2070828T3 (es) * 1986-03-27 1995-06-16 Monsanto Co Estimulacion de la produccion de proteina en bacterias empleando un nuevo sitio de union al ribosoma.
FR2597114B1 (fr) * 1986-04-10 1994-02-25 Sanofi Procede microbiologique pour l'obtention d'une proteine par culture d'une souche bacterienne mutante
IT1221765B (it) * 1986-05-07 1990-07-12 Eniricerche Spa Sequenza nucleotidica capace di indurre alti livelli di traduzione di un gene eterologo in bacillus subtilis ed escherichia coli
FR2599753B1 (fr) * 1986-06-05 1989-12-08 Sanofi Sa Sequence d'adn composite et son application pour la production de l'hormone de croissance

Also Published As

Publication number Publication date
FR2636644B1 (fr) 1990-12-28
DE68919619T2 (de) 1995-05-24
DE68919619D1 (de) 1995-01-12
JPH02113889A (ja) 1990-04-26
EP0360641B1 (de) 1994-11-30
CA1337180C (en) 1995-10-03
FR2636644A1 (fr) 1990-03-23
JP2662044B2 (ja) 1997-10-08
ES2066008T3 (es) 1995-03-01
PT91510A (pt) 1990-03-08
PT91510B (pt) 1995-07-18
EP0360641A1 (de) 1990-03-28
GR3014930T3 (en) 1995-05-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time