ES2066008T3 - Secuencia de adn que participa en la regulacion de la expresion de una secuencia de adn que codifica un precursor de un polipeptido, vectores de expresion y procedimiento de produccion periplasmica del polipeptido. - Google Patents
Secuencia de adn que participa en la regulacion de la expresion de una secuencia de adn que codifica un precursor de un polipeptido, vectores de expresion y procedimiento de produccion periplasmica del polipeptido.Info
- Publication number
- ES2066008T3 ES2066008T3 ES89402329T ES89402329T ES2066008T3 ES 2066008 T3 ES2066008 T3 ES 2066008T3 ES 89402329 T ES89402329 T ES 89402329T ES 89402329 T ES89402329 T ES 89402329T ES 2066008 T3 ES2066008 T3 ES 2066008T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptide
- dna sequence
- expression
- regulation
- precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000013604 expression vector Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000002265 Human Growth Hormone Human genes 0.000 abstract 1
- 108010000521 Human Growth Hormone Proteins 0.000 abstract 1
- 239000000854 Human Growth Hormone Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
SECUENCIA DE ADN PARTICIPANTE EN LA REGULACION DE LA EXPRESION DE UNA SECUENCIA DE ADN QUE CODIFICA PARA UN PRECURSOR DE UN POLIPEPTIDO. VECTORES DE EXPRESION QUE CONTIENEN TAL SECUENCIA. PROCEDIMIENTO PARA LA OBTENCION PERIPLASMICA DE UN POLIPEPTIDO EN UNA CEPA DE BACTERIAS GRAM NEGATIVAS TRANSFORMADA POR UNO DE ESTOS VECTORES. APLICACION A LA OBTENCION DE HORMONA DE CRECIMIENTO HUMANA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8811187A FR2636644B1 (fr) | 1988-08-24 | 1988-08-24 | Sequence d'adn participant a la regulation de l'expression d'une sequence d'adn codant pour un precurseur d'un polypeptide, vecteurs d'expression et procede de production periplasmique du polypeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2066008T3 true ES2066008T3 (es) | 1995-03-01 |
Family
ID=9369497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89402329T Expired - Lifetime ES2066008T3 (es) | 1988-08-24 | 1989-08-23 | Secuencia de adn que participa en la regulacion de la expresion de una secuencia de adn que codifica un precursor de un polipeptido, vectores de expresion y procedimiento de produccion periplasmica del polipeptido. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0360641B1 (es) |
JP (1) | JP2662044B2 (es) |
AT (1) | ATE114719T1 (es) |
CA (1) | CA1337180C (es) |
DE (1) | DE68919619T2 (es) |
ES (1) | ES2066008T3 (es) |
FR (1) | FR2636644B1 (es) |
GR (1) | GR3014930T3 (es) |
PT (1) | PT91510B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2729972B1 (fr) * | 1995-01-31 | 1997-04-18 | Sanofi Sa | Procede d'extraction de proteines periplasmiques de microorganismes procaryotes en presence d'arginine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340091C (en) * | 1986-03-27 | 1998-10-20 | Peter Olafs Olins | Enhanced protein production in bacteria by employing novel ribosome binding site |
FR2597114B1 (fr) * | 1986-04-10 | 1994-02-25 | Sanofi | Procede microbiologique pour l'obtention d'une proteine par culture d'une souche bacterienne mutante |
IT1221765B (it) * | 1986-05-07 | 1990-07-12 | Eniricerche Spa | Sequenza nucleotidica capace di indurre alti livelli di traduzione di un gene eterologo in bacillus subtilis ed escherichia coli |
FR2599753B1 (fr) * | 1986-06-05 | 1989-12-08 | Sanofi Sa | Sequence d'adn composite et son application pour la production de l'hormone de croissance |
-
1988
- 1988-08-24 FR FR8811187A patent/FR2636644B1/fr not_active Expired - Lifetime
-
1989
- 1989-08-22 PT PT91510A patent/PT91510B/pt not_active IP Right Cessation
- 1989-08-23 DE DE68919619T patent/DE68919619T2/de not_active Expired - Lifetime
- 1989-08-23 CA CA000609136A patent/CA1337180C/en not_active Expired - Lifetime
- 1989-08-23 AT AT89402329T patent/ATE114719T1/de not_active IP Right Cessation
- 1989-08-23 EP EP89402329A patent/EP0360641B1/fr not_active Expired - Lifetime
- 1989-08-23 ES ES89402329T patent/ES2066008T3/es not_active Expired - Lifetime
- 1989-08-24 JP JP1220105A patent/JP2662044B2/ja not_active Expired - Lifetime
-
1995
- 1995-02-01 GR GR950400194T patent/GR3014930T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FR2636644B1 (fr) | 1990-12-28 |
EP0360641A1 (fr) | 1990-03-28 |
GR3014930T3 (en) | 1995-05-31 |
DE68919619D1 (de) | 1995-01-12 |
CA1337180C (en) | 1995-10-03 |
PT91510A (pt) | 1990-03-08 |
DE68919619T2 (de) | 1995-05-24 |
JPH02113889A (ja) | 1990-04-26 |
JP2662044B2 (ja) | 1997-10-08 |
FR2636644A1 (fr) | 1990-03-23 |
EP0360641B1 (fr) | 1994-11-30 |
PT91510B (pt) | 1995-07-18 |
ATE114719T1 (de) | 1994-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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