ATE108799T1 - Konjugate von in position c-3 eine detergens- kette enthaltenden vinca-derivaten. - Google Patents
Konjugate von in position c-3 eine detergens- kette enthaltenden vinca-derivaten.Info
- Publication number
- ATE108799T1 ATE108799T1 AT89400334T AT89400334T ATE108799T1 AT E108799 T1 ATE108799 T1 AT E108799T1 AT 89400334 T AT89400334 T AT 89400334T AT 89400334 T AT89400334 T AT 89400334T AT E108799 T1 ATE108799 T1 AT E108799T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- derivatives containing
- chain
- detergent
- vinca
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8801439A FR2626882B1 (fr) | 1988-02-08 | 1988-02-08 | Conjugues de derives de vinca comportant une chaine detergente en position c-3 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE108799T1 true ATE108799T1 (de) | 1994-08-15 |
Family
ID=9363041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89400334T ATE108799T1 (de) | 1988-02-08 | 1989-02-07 | Konjugate von in position c-3 eine detergens- kette enthaltenden vinca-derivaten. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5024835A (de) |
EP (1) | EP0328446B1 (de) |
JP (1) | JP2930965B2 (de) |
AT (1) | ATE108799T1 (de) |
CA (1) | CA1336119C (de) |
DE (1) | DE68916820T2 (de) |
ES (1) | ES2057157T3 (de) |
FR (1) | FR2626882B1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4122210C2 (de) * | 1991-07-04 | 1999-04-01 | Deutsches Krebsforsch | Konjugate aus tumoraktiver Verbindung und Serumalbumin sowie Verfahren zu deren Herstellung und ihre Verwendung |
US5379254A (en) * | 1992-10-20 | 1995-01-03 | National Semiconductor Corporation | Asymmetrical alternate metal virtual ground EPROM array |
US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
US6143864A (en) * | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
US5599686A (en) * | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
AU694546C (en) * | 1994-08-19 | 2001-09-06 | La Region Wallonne | Compounds, pharmaceutical composition and diagnostic device comprising same and their use |
DE4433890C2 (de) * | 1994-09-22 | 1999-02-18 | Deutsches Krebsforsch | Konjugat aus einem Wirkstoff und einem nicht als körperfremd angesehenen, nativen Protein |
JPH11511137A (ja) * | 1995-08-08 | 1999-09-28 | ファイブロゲン,インコーポレーテッド | コラーゲンの過剰生産に関係した疾患を治療するためのc−プロテイナーゼ阻害剤 |
US5998362A (en) * | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6127333A (en) * | 1997-07-10 | 2000-10-03 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6391305B1 (en) | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
KR100580137B1 (ko) * | 1997-12-02 | 2006-05-16 | 머크 앤드 캄파니 인코포레이티드 | 전립선 암 치료에 유용한 접합체 및 이를 포함하는 약제학적 조성물 |
ZA9810974B (en) * | 1997-12-02 | 1999-06-03 | Merck & Co Inc | Conjugates useful in the treatment of prostate cancer |
US20040081659A1 (en) * | 1997-12-02 | 2004-04-29 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
AU5240999A (en) * | 1998-07-31 | 2000-02-21 | Goldsmith Seeds Inc. | Trimeric and polymeric alkaloids |
US6174858B1 (en) | 1998-11-17 | 2001-01-16 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US7425541B2 (en) * | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
CA2413149A1 (en) | 2000-06-14 | 2001-12-20 | Medarex, Inc. | Prodrug compounds with isoleucine |
JP2004527727A (ja) * | 2000-07-05 | 2004-09-09 | シーアールティ ホールディングス、インク | 電磁気放射起動プラズマ反応炉 |
US20030232760A1 (en) * | 2001-09-21 | 2003-12-18 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US8946387B2 (en) * | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8968730B2 (en) * | 2002-08-14 | 2015-03-03 | Macrogenics Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8193318B2 (en) * | 2002-08-14 | 2012-06-05 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8044180B2 (en) * | 2002-08-14 | 2011-10-25 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8187593B2 (en) * | 2002-08-14 | 2012-05-29 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8530627B2 (en) * | 2002-08-14 | 2013-09-10 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US20090017023A1 (en) * | 2002-08-14 | 2009-01-15 | Macrogenics, Inc. | FcGammaRIIB Specific Antibodies and Methods of Use Thereof |
WO2004063351A2 (en) * | 2003-01-09 | 2004-07-29 | Macrogenics, Inc. | IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME |
US7960512B2 (en) * | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
US20050148534A1 (en) * | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
CN1878568A (zh) * | 2003-11-05 | 2006-12-13 | 盘林京有限公司 | Cdim结合抗体的增强的b细胞细胞毒性 |
EP1761563A4 (de) * | 2004-05-10 | 2008-05-14 | Macrogenics Inc | HUMANISIERTE FC gamma SPEZIFISCHE ANTIKÖRPER UND VERFAHREN ZU DEREN ANWENDUNG |
CA2587766A1 (en) * | 2004-11-10 | 2007-03-01 | Macrogenics, Inc. | Engineering fc antibody regions to confer effector function |
AU2006279945B2 (en) * | 2005-08-10 | 2012-04-12 | Macrogenics, Inc. | Identification and engineering of antibodies with variant FC regions and methods of using same |
WO2007106707A2 (en) * | 2006-03-10 | 2007-09-20 | Macrogenics, Inc. | Identification and engineering of antibodies with variant heavy chains and methods of using same |
WO2008105886A2 (en) * | 2006-05-26 | 2008-09-04 | Macrogenics, Inc. | HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
EP2032159B1 (de) * | 2006-06-26 | 2015-01-07 | MacroGenics, Inc. | Kombination aus fcgammariib-antikörpern und cd20-spezifischen antikörpern sowie verwendungsverfahren dafür |
EP2029173B1 (de) | 2006-06-26 | 2016-07-20 | MacroGenics, Inc. | Fc-riib-spezifische antikörper und verfahren zu ihrer anwendung |
US20080112961A1 (en) * | 2006-10-09 | 2008-05-15 | Macrogenics, Inc. | Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same |
US8652466B2 (en) | 2006-12-08 | 2014-02-18 | Macrogenics, Inc. | Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting |
SG189730A1 (en) | 2008-04-02 | 2013-05-31 | Macrogenics Inc | Her2/neu-specific antibodies and methods of using same |
US8669349B2 (en) | 2008-04-02 | 2014-03-11 | Macrogenics, Inc. | BCR-complex-specific antibodies and methods of using same |
EP2282770B1 (de) * | 2008-06-04 | 2018-03-07 | MacroGenics, Inc. | Antikörper mit veränderter bindung an fcrn und verwendungsverfahren dafür |
WO2011044368A1 (en) | 2009-10-07 | 2011-04-14 | Macrogenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
HUE045487T2 (hu) | 2010-03-04 | 2019-12-30 | Macrogenics Inc | B7-H3-ra reaktív antitestek, immunológiailag aktív fragmenseik és alkalmazásaik |
US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
CN107206101B (zh) * | 2014-12-03 | 2021-06-25 | 基因泰克公司 | 季铵化合物及其抗体-药物缀合物 |
EP3442574A4 (de) | 2016-04-15 | 2019-12-11 | MacroGenics, Inc. | Neuartige b7-h3-bindende moleküle, antikörper-wirkstoff-konjugate davon und verfahren zur verwendung davon |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU83822A1 (fr) * | 1981-12-08 | 1983-09-01 | Omnichem Sa | Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique |
OA06421A (fr) * | 1980-06-10 | 1981-09-30 | Omnium Chimique Sa | Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides. |
FI820020L (fi) * | 1981-01-12 | 1982-07-13 | Lilly Industries Ltd | Immunoglobulinkonjugater |
EP0121388B1 (de) * | 1983-03-30 | 1990-06-13 | Lilly Industries Limited | Immunoglobulinkonjugate |
EP0124502B1 (de) * | 1983-04-29 | 1991-06-12 | OMNICHEM Société anonyme | Konjugierte Vinblastin-Verbindungen und ihre Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
US4675400A (en) * | 1985-06-17 | 1987-06-23 | Eli Lilly And Company | Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids |
EP0232693A3 (de) * | 1985-12-16 | 1988-04-06 | La Region Wallonne | Konjugate des Vinblastins und seiner Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
FR2592883B1 (fr) * | 1986-01-13 | 1988-09-16 | Ire Celltarg Sa | Derives de vinblastine et composition pharmaceutique les contenant |
JPH075608B2 (ja) * | 1986-01-13 | 1995-01-25 | イ−ル−セルタ−ク ソシエテ アノニム | ビンブラスチン誘導体 |
-
1988
- 1988-02-08 FR FR8801439A patent/FR2626882B1/fr not_active Expired - Fee Related
-
1989
- 1989-02-03 US US07/306,639 patent/US5024835A/en not_active Expired - Lifetime
- 1989-02-07 EP EP89400334A patent/EP0328446B1/de not_active Expired - Lifetime
- 1989-02-07 DE DE68916820T patent/DE68916820T2/de not_active Expired - Fee Related
- 1989-02-07 AT AT89400334T patent/ATE108799T1/de active
- 1989-02-07 ES ES89400334T patent/ES2057157T3/es not_active Expired - Lifetime
- 1989-02-07 CA CA000590274A patent/CA1336119C/fr not_active Expired - Fee Related
- 1989-02-08 JP JP1027744A patent/JP2930965B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH02152992A (ja) | 1990-06-12 |
US5024835A (en) | 1991-06-18 |
EP0328446B1 (de) | 1994-07-20 |
FR2626882A1 (fr) | 1989-08-11 |
CA1336119C (fr) | 1995-06-27 |
FR2626882B1 (fr) | 1991-11-08 |
JP2930965B2 (ja) | 1999-08-09 |
ES2057157T3 (es) | 1994-10-16 |
DE68916820T2 (de) | 1995-03-09 |
DE68916820D1 (de) | 1994-08-25 |
EP0328446A1 (de) | 1989-08-16 |
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