ATA936176A - Verfahren zur herstellung neuer, basisch substituierter indolderivate und deren saeure- additionssalze - Google Patents
Verfahren zur herstellung neuer, basisch substituierter indolderivate und deren saeure- additionssalzeInfo
- Publication number
- ATA936176A ATA936176A AT936176A AT936176A ATA936176A AT A936176 A ATA936176 A AT A936176A AT 936176 A AT936176 A AT 936176A AT 936176 A AT936176 A AT 936176A AT A936176 A ATA936176 A AT A936176A
- Authority
- AT
- Austria
- Prior art keywords
- acid addition
- addition salts
- producing new
- basicly
- substituted
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT576379A AT357519B (de) | 1975-12-19 | 1979-08-28 | Verfahren zur herstellung neuer, basisch substituierter indolderivate und deren saeure- additionssalze |
| AT576279A AT357518B (de) | 1975-12-19 | 1979-08-28 | Verfahren zur herstellung neuer,basisch substi- tuierter indolderivate und deren saeure- additionssalze |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752557341 DE2557341A1 (de) | 1975-12-19 | 1975-12-19 | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATA936176A true ATA936176A (de) | 1980-01-15 |
Family
ID=5964904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT936176A ATA936176A (de) | 1975-12-19 | 1976-12-17 | Verfahren zur herstellung neuer, basisch substituierter indolderivate und deren saeure- additionssalze |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4148895A (OSRAM) |
| JP (1) | JPS5277067A (OSRAM) |
| AT (1) | ATA936176A (OSRAM) |
| AU (1) | AU2070076A (OSRAM) |
| BE (1) | BE849627A (OSRAM) |
| DE (1) | DE2557341A1 (OSRAM) |
| DK (1) | DK571476A (OSRAM) |
| EG (1) | EG12485A (OSRAM) |
| ES (1) | ES454234A1 (OSRAM) |
| FI (1) | FI763622A7 (OSRAM) |
| FR (1) | FR2335215A1 (OSRAM) |
| GB (1) | GB1573809A (OSRAM) |
| GR (1) | GR61172B (OSRAM) |
| IL (1) | IL51119A0 (OSRAM) |
| IT (1) | IT1065425B (OSRAM) |
| LU (1) | LU76426A1 (OSRAM) |
| NL (1) | NL7614052A (OSRAM) |
| NO (1) | NO764299L (OSRAM) |
| NZ (1) | NZ182908A (OSRAM) |
| PT (1) | PT65980B (OSRAM) |
| SE (1) | SE7614218L (OSRAM) |
| ZA (1) | ZA767522B (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH653021A5 (fr) * | 1981-04-24 | 1985-12-13 | Delalande Sa | Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant. |
| JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
| US4588740A (en) * | 1982-12-07 | 1986-05-13 | Smithkline Beckman Corporation | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones |
| FR2557110B1 (fr) * | 1983-12-23 | 1989-11-24 | Sandoz Sa | Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments |
| FR2578842B1 (fr) * | 1985-03-15 | 1987-04-10 | Rhone Poulenc Sante | Nouveaux derives de la pyrrolo(1,2-a) azepinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE3531658A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
| US5004812A (en) * | 1987-06-26 | 1991-04-02 | E. I. Du Pont De Nemours And Company | Direct positive dimethine cyanine dyes containing 1-aryl-2-heteroaryl indole nucleus |
| US5254552A (en) * | 1988-05-24 | 1993-10-19 | American Home Products Corporation | Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity |
| EP0636623B1 (en) * | 1990-06-07 | 2001-08-16 | AstraZeneca AB | Indole derivatives as 5-HT1- like agonists |
| US5229517A (en) * | 1990-09-27 | 1993-07-20 | Hoechst-Roussel Pharmaceuticals Incorporated | 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds |
| US5102889B1 (en) * | 1990-09-27 | 1993-05-11 | 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds | |
| US5284862A (en) * | 1991-03-18 | 1994-02-08 | Warner-Lambert Company | Derivatives of 2-carboxyindoles having pharmaceutical activity |
| JP3140155B2 (ja) * | 1992-03-09 | 2001-03-05 | 杏林製薬株式会社 | Ｎ，ｎ’−ジ置換アミド誘導体 |
| ES2063700B1 (es) * | 1993-04-28 | 1995-07-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, proceso para su preparacion y composiciones farmaceuticas que lo contengan. |
| JP2000507556A (ja) * | 1996-03-28 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | ケモカインのカルボン酸インドール阻害剤 |
| US6342498B1 (en) | 1997-10-22 | 2002-01-29 | Eli Lilly And Company | Arylpiperazines as serotonin reuptake inhibitors and 5-HT1Dα antagonists |
| JP2003040866A (ja) * | 2001-07-31 | 2003-02-13 | Nippon Kayaku Co Ltd | Ｎ置換インドール誘導体、その製造法及びそれを有効成分とする害虫防除剤 |
| WO2005023246A1 (en) * | 2003-09-04 | 2005-03-17 | Aventis Pharmaceuticals Inc. | Substituted indoles as inhibitors of poly (adp-ribose) polymerase (parp) |
| CA2858520A1 (en) * | 2006-05-18 | 2007-11-29 | Pharmacyclics Inc. | Intracellular kinase inhibitors |
| MX2009013332A (es) | 2007-06-08 | 2010-01-25 | Mannkind Corp | Inhibidores de ire-1 alfa. |
| KR20100121610A (ko) * | 2008-01-31 | 2010-11-18 | 사노피-아벤티스 | 사이클릭 인돌―３―카복스아미드, 이들의 제조방법 및 약제로서의 이들의 용도 |
| KR20120117905A (ko) * | 2010-01-28 | 2012-10-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 프로테아좀 활성을 향상시키는 조성물 및 방법 |
| SMT201900280T1 (it) | 2011-05-12 | 2019-07-11 | Proteostasis Therapeutics Inc | Regolatori di proteostasi |
| WO2014116228A1 (en) | 2013-01-25 | 2014-07-31 | President And Fellows Of Harvard College | Usp14 inhibitors for treating or preventing viral infections |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3320278A (en) * | 1965-06-30 | 1967-05-16 | Merck & Co Inc | Alpha-(2-amino)-3-indolyl lower aliphatic acid derivatives |
| US3847920A (en) * | 1973-05-17 | 1974-11-12 | Warner Lambert Co | 3-substituted pyrimido(4,5-b)indoles |
| US3980668A (en) * | 1974-09-18 | 1976-09-14 | Bristol-Myers Company | Anti-arrhythimic 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2,2,1]heptane-2,3-di-endo-carboxylic acid imides |
-
1975
- 1975-12-19 DE DE19752557341 patent/DE2557341A1/de not_active Withdrawn
-
1976
- 1976-12-14 ES ES454234A patent/ES454234A1/es not_active Expired
- 1976-12-16 FI FI763622A patent/FI763622A7/fi not_active Application Discontinuation
- 1976-12-16 US US05/751,084 patent/US4148895A/en not_active Expired - Lifetime
- 1976-12-17 IL IL51119A patent/IL51119A0/xx unknown
- 1976-12-17 AU AU20700/76A patent/AU2070076A/en not_active Expired
- 1976-12-17 SE SE7614218A patent/SE7614218L/xx unknown
- 1976-12-17 NO NO764299A patent/NO764299L/no unknown
- 1976-12-17 ZA ZA767522A patent/ZA767522B/xx unknown
- 1976-12-17 NZ NZ182908A patent/NZ182908A/xx unknown
- 1976-12-17 LU LU76426A patent/LU76426A1/xx unknown
- 1976-12-17 PT PT65980A patent/PT65980B/pt unknown
- 1976-12-17 DK DK571476A patent/DK571476A/da not_active Application Discontinuation
- 1976-12-17 NL NL7614052A patent/NL7614052A/xx not_active Application Discontinuation
- 1976-12-17 AT AT936176A patent/ATA936176A/de not_active Application Discontinuation
- 1976-12-17 IT IT30581/76A patent/IT1065425B/it active
- 1976-12-18 JP JP51151502A patent/JPS5277067A/ja active Pending
- 1976-12-18 EG EG772/76A patent/EG12485A/xx active
- 1976-12-18 GR GR52437A patent/GR61172B/el unknown
- 1976-12-20 GB GB53125/76A patent/GB1573809A/en not_active Expired
- 1976-12-20 BE BE173448A patent/BE849627A/xx unknown
- 1976-12-20 FR FR7638399A patent/FR2335215A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PT65980B (de) | 1978-07-05 |
| US4148895A (en) | 1979-04-10 |
| FI763622A7 (OSRAM) | 1977-06-20 |
| FR2335215A1 (fr) | 1977-07-15 |
| ES454234A1 (es) | 1977-12-16 |
| GB1573809A (en) | 1980-08-28 |
| AU2070076A (en) | 1978-06-22 |
| EG12485A (en) | 1981-06-30 |
| NZ182908A (en) | 1979-08-31 |
| DE2557341A1 (de) | 1977-06-30 |
| IL51119A0 (en) | 1977-02-28 |
| BE849627A (fr) | 1977-06-20 |
| NL7614052A (nl) | 1977-06-21 |
| ZA767522B (en) | 1977-11-30 |
| SE7614218L (sv) | 1977-06-20 |
| GR61172B (en) | 1978-10-03 |
| PT65980A (de) | 1977-01-01 |
| IT1065425B (it) | 1985-02-25 |
| DK571476A (da) | 1977-06-20 |
| NO764299L (OSRAM) | 1977-06-21 |
| JPS5277067A (en) | 1977-06-29 |
| LU76426A1 (OSRAM) | 1977-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1Z | Withdrawn |