ATA450676A - Verfahren zur herstellung von anthracyclinglycosiden - Google Patents

Verfahren zur herstellung von anthracyclinglycosiden

Info

Publication number
ATA450676A
ATA450676A AT450676A AT450676A ATA450676A AT A450676 A ATA450676 A AT A450676A AT 450676 A AT450676 A AT 450676A AT 450676 A AT450676 A AT 450676A AT A450676 A ATA450676 A AT A450676A
Authority
AT
Austria
Prior art keywords
anthracycling
lycosides
manufacturing
manufacturing anthracycling
anthracycling lycosides
Prior art date
Application number
AT450676A
Other languages
English (en)
Other versions
AT344899B (de
Inventor
Federico Arcamone
Luigi Bernardi
Bianca Patelli
Sergio Penco
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of ATA450676A publication Critical patent/ATA450676A/de
Application granted granted Critical
Publication of AT344899B publication Critical patent/AT344899B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT450676A 1976-06-14 1976-06-21 Verfahren zur herstellung von anthracyclinglycosiden AT344899B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7617955A FR2355028A1 (fr) 1976-06-14 1976-06-14 Procede pour la preparation de glycosides derives d'anthracyclines optiquement actives

Publications (2)

Publication Number Publication Date
ATA450676A true ATA450676A (de) 1977-12-15
AT344899B AT344899B (de) 1978-08-10

Family

ID=9174331

Family Applications (2)

Application Number Title Priority Date Filing Date
AT636377A AT345461B (de) 1976-06-14 1976-06-21 Verfahren zur trennung von racemischen aglyconen
AT450676A AT344899B (de) 1976-06-14 1976-06-21 Verfahren zur herstellung von anthracyclinglycosiden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT636377A AT345461B (de) 1976-06-14 1976-06-21 Verfahren zur trennung von racemischen aglyconen

Country Status (11)

Country Link
US (1) US4107423A (de)
JP (1) JPS532463A (de)
AT (2) AT345461B (de)
BE (1) BE842930A (de)
CA (1) CA1046510A (de)
CH (1) CH622529A5 (de)
DE (1) DE2626783C2 (de)
FR (1) FR2355028A1 (de)
GB (1) GB1509875A (de)
NL (2) NL175300C (de)
SE (2) SE421318B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
IL55431A (en) * 1978-08-24 1982-07-30 Yeda Res & Dev Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
GB2056443B (en) * 1979-08-20 1984-01-18 Hoffmann La Roche Cyclic compounds
JPS56135021A (en) * 1980-03-25 1981-10-22 Nippon Kokan Kk <Nkk> Lining for internal surface of welded part of steel pipe
CA1174669A (en) * 1980-07-18 1984-09-18 Michael J. Broadhurst Anthracycline glycosides
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US4540695A (en) * 1981-08-12 1985-09-10 Sumitomo Chemical Co., Ltd. Aminonaphthacene derivatives and their use
NL8300150A (nl) * 1982-01-26 1983-08-16 Erba Farmitalia Daunorubicine en doxorubicine-analoga, hun bereiding en toepassing.
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
US4831019A (en) * 1983-10-31 1989-05-16 Adria Laboratories, Inc. Pharmaceutical preparations of 4-demethoxy-n-trifluoroacetyl anthracyclines
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
NZ224252A (en) 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
DE10155016A1 (de) * 2001-11-07 2003-05-15 Knoell Hans Forschung Ev Neue Chinon-Verbindung, Verfahren zur Herstellung und deren Verwendung
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010075517A2 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
SG172363A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
CL2009002207A1 (es) 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
AP3515A (en) 2010-03-31 2016-01-11 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8846882B2 (en) * 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin
CN104151376B (zh) * 2014-06-23 2017-02-08 天津药物研究院新药评价有限公司 一种抗肿瘤药物及其合成方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427300A (en) * 1965-11-12 1969-02-11 Merck & Co Inc Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3629231A (en) * 1968-05-23 1971-12-21 Biorex Laboratories Ltd Derivatives of glycyrrhetinic acid
FI51808C (fi) * 1968-07-15 1977-04-12 Rhone Poulenc Sa Menetelmä uusien kasvainten naftaseenijohdannaisten valmistamiseksi.
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates

Also Published As

Publication number Publication date
NL7606897A (nl) 1977-12-28
US4107423A (en) 1978-08-15
NL175300C (nl) 1984-10-16
NL175300B (nl) 1984-05-16
FR2355028A1 (fr) 1978-01-13
SE447988B (sv) 1987-01-12
JPS532463A (en) 1978-01-11
BE842930A (fr) 1976-10-01
FR2355028B3 (de) 1979-03-02
GB1509875A (en) 1978-05-04
JPS6123200B2 (de) 1986-06-04
AT345461B (de) 1978-09-25
NL930090I2 (nl) 1994-03-16
DE2626783A1 (de) 1977-12-29
SE8100471L (sv) 1981-01-26
CH622529A5 (en) 1981-04-15
AT344899B (de) 1978-08-10
SE7606808L (sv) 1977-12-16
ATA636377A (de) 1978-01-15
SE421318B (sv) 1981-12-14
DE2626783C2 (de) 1985-08-14
NL930090I1 (nl) 1993-10-01
CA1046510A (en) 1979-01-16

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Legal Events

Date Code Title Description
EIH Change in the person of patent owner
EIH Change in the person of patent owner
ELA Expired due to lapse of time
EZF Grant of a certificate of protection

Free format text: SZ 111/94, 941221, EXPIRES:20001215

SZA Application filed for a certificate of protection

Free format text: SZ 111/94, 941221