ATA107397A - Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons - Google Patents
Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklonsInfo
- Publication number
- ATA107397A ATA107397A AT107397A AT107397A ATA107397A AT A107397 A ATA107397 A AT A107397A AT 107397 A AT107397 A AT 107397A AT 107397 A AT107397 A AT 107397A AT A107397 A ATA107397 A AT A107397A
- Authority
- AT
- Austria
- Prior art keywords
- cell clone
- serum
- protein
- obtaining
- free medium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
US09/100,253 US6100061A (en) | 1997-06-20 | 1998-06-19 | Recombinant cell clone having increased stability in serum- and protein-free medium and a method of recovering the stable cell clone and the production of recombinant proteins by using a stable cell clone |
US09/324,612 US6475725B1 (en) | 1997-06-20 | 1999-06-02 | Recombinant cell clones having increased stability and methods of making and using the same |
US10/170,661 US6936441B2 (en) | 1997-06-20 | 2002-06-12 | Recombinant cell clones having increased stability and methods of making and using the same |
US11/123,362 US7094574B2 (en) | 1997-06-20 | 2005-05-06 | Recombinant cell clones having increased stability and methods of making and using the same |
US11/482,504 US20070161079A1 (en) | 1997-06-20 | 2006-07-07 | Recombinant cell clones having increased stability and methods of making and using the same |
US12/488,465 US8080414B2 (en) | 1997-06-20 | 2009-06-19 | Recombinant cell clones having increased stability and methods of making and using the same |
US12/488,441 US20090258391A1 (en) | 1997-06-20 | 2009-06-19 | Recombinant cell clones having increased stability and methods of making and using same |
US12/778,776 US8084251B2 (en) | 1997-06-20 | 2010-05-12 | Recombinant cell clones having increased stability and methods of making and using the same |
US12/848,897 US8084252B2 (en) | 1997-06-20 | 2010-08-02 | Recombinant cell clones having increased stability and methods of making and using the same |
US12/986,111 US8329465B2 (en) | 1997-06-20 | 2011-01-06 | Recombinant cell clones having increased stability and methods of making and using the same |
US14/567,942 USRE46745E1 (en) | 1997-06-20 | 2014-12-11 | Recombinant cell clones having increased stability and methods of making and using the same |
US15/203,558 USRE46860E1 (en) | 1997-06-20 | 2016-07-06 | Recombinant cell clones having increased stability and methods of making and using the same |
US15/203,550 USRE46897E1 (en) | 1997-06-20 | 2016-07-06 | Recombinant cell clones having increased stability and methods of making and using the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA107397A true ATA107397A (de) | 2000-06-15 |
AT407255B AT407255B (de) | 2001-02-26 |
Family
ID=3506017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
Country Status (2)
Country | Link |
---|---|
US (1) | US6100061A (de) |
AT (1) | AT407255B (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
WO1998008934A1 (en) * | 1996-08-30 | 1998-03-05 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
US6475725B1 (en) * | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
WO2001058935A2 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7812132B2 (en) * | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
WO2002029083A2 (en) * | 2000-10-02 | 2002-04-11 | Novo Nordisk A/S | Industrial-scale serum-free production of recombinant proteins in mammalian cells |
US20040185535A1 (en) * | 2003-03-21 | 2004-09-23 | Giles Wilson | Industrial-scale serum-free production of recombinant FVII in mammalian cells |
US20040185534A1 (en) * | 2000-10-02 | 2004-09-23 | Knudsen Ida Molgaard | Industrial-scale serum-free production of recombinant proteins in mammalian cells |
US7445924B2 (en) * | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
EP1434857B1 (de) * | 2001-10-02 | 2007-08-01 | Novo Nordisk Health Care AG | Verfahren zur herstelllung rekombinanter proteine in eukaryontischen zellen |
US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
US6825027B2 (en) | 2001-12-10 | 2004-11-30 | Baxter Healthcare S.A. | Method of production of purified hepatitis a virus particles and vaccine preparation |
US6830917B2 (en) * | 2001-12-10 | 2004-12-14 | Baxter Healthcare S.A. | Method of isolation and purification of trypsin from pronase protease and use thereof |
DK1499719T3 (da) * | 2002-04-30 | 2011-02-28 | Bayer Healthcare Llc | Faktor VII- eller VIIa-polypeptidvarianter |
JP3916516B2 (ja) * | 2002-06-10 | 2007-05-16 | 独立行政法人科学技術振興機構 | 硬組織−軟組織界面再生用足場材料 |
CN101058800B (zh) | 2002-07-09 | 2013-03-13 | 巴克斯特国际有限公司 | 用于细胞培养的无动物蛋白质培养基 |
PT1434858E (pt) * | 2002-09-05 | 2008-07-28 | Bavarian Nordic As | Método de amplificação de um poxvírus em condições sem soro |
CA2502162C (en) * | 2002-09-30 | 2014-04-15 | Maxygen Holdings Ltd. | Fvii or fviia variants having increased clotting activity |
CU23097A1 (es) * | 2002-10-23 | 2005-11-18 | Centro Inmunologia Molecular | Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método |
ES2386010T3 (es) * | 2003-03-20 | 2012-08-07 | Bayer Healthcare Llc | Variantes de FVII o FVIIa |
SI1644504T1 (sl) * | 2003-06-19 | 2010-06-30 | Bayer Healthcare Llc | Variante Gla domene faktorja VII ali VIIa |
CN1890257A (zh) * | 2003-12-01 | 2007-01-03 | 诺和诺德医疗保健公司 | 液体因子ⅶ组合物的病毒过滤 |
CA2551026A1 (en) * | 2003-12-23 | 2005-07-14 | Schering Corporation | Methods for producing a549 cell lines stable in serum-free medium suspension culture |
RU2006138181A (ru) | 2004-05-04 | 2008-06-10 | Ново Нордиск Хелс Кеа Аг (Ch) | О-связанные гликоформы полипептидов и способ их изготовления |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
JP2008512097A (ja) * | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | アプタマー医薬品化学 |
BRPI0514984A (pt) | 2004-09-07 | 2008-07-01 | Archemix Corp | aptámeros para o fator de von willebrand e sua utilização como terapêuticos para doença trombótica |
US20060094104A1 (en) * | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
EP1851305B1 (de) * | 2005-02-11 | 2012-01-18 | Novo Nordisk Health Care AG | Herstellung eines proteins in serumfreier zellkultur, die ein proteinhydrolysat aus pflanzen enthält |
US20070231895A1 (en) * | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
KR101423344B1 (ko) * | 2006-01-04 | 2014-07-30 | 백스터 인터내셔널 인코포레이티드 | 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 |
EP2423306A1 (de) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modifizierte Gerinnungsfaktor-IX-Polypeptide und deren Verwendung bei der Behandlung |
JP5401446B2 (ja) | 2007-04-26 | 2014-01-29 | バイエル ヘルスケア エルエルシー | 凍結貯蔵を目的とした、組み換えタンパク質溶液の安定化 |
WO2008150495A2 (en) * | 2007-06-01 | 2008-12-11 | Archemix Corp. | Vwf aptamer formulations and methods for use |
PT2235197T (pt) * | 2007-12-27 | 2017-10-11 | Baxalta Inc | Processos para cultura de células |
US20110014624A1 (en) * | 2008-03-12 | 2011-01-20 | Wyeth Llc | Methods For Identifying Cells Suitable For Large-Scale Production of Recombinant Proteins |
HUE026210T2 (en) | 2008-11-12 | 2016-05-30 | Baxalta Inc | Procedure for serum-free, insulin-free VII. factor |
BR122021005965B1 (pt) | 2009-07-31 | 2022-01-25 | Baxalta Incorporated | Método para produzir uma composição de desintegrina e metaloproteinase com motivo trombospondina (adamts) |
US8623352B2 (en) | 2009-09-21 | 2014-01-07 | Baxter International Inc. | Stabilized liquid and lyophilized ADAMTS13 formulations |
IL286298B (en) | 2010-07-08 | 2022-08-01 | Baxalta Inc | A method to generate high molecular weight substituted vwf in cell culture |
CA2807607A1 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
CN103282042B (zh) | 2010-09-17 | 2014-12-10 | 巴克斯特国际公司 | 通过具有组氨酸的水性制剂在弱酸性至中性pH稳定的免疫球蛋白 |
TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
HUE035941T2 (en) | 2011-08-02 | 2018-05-28 | Baxalta GmbH | Systems and Methods for Recombinant Production Methods to Increase Protein Yield |
AU2013202965B2 (en) | 2013-03-15 | 2016-07-21 | Takeda Pharmaceutical Company Limited | Improved method for producing factor h from a plasma precipitation fraction |
JP6742902B2 (ja) | 2013-03-15 | 2020-08-19 | ジェンザイム・コーポレーション | 高密度細胞バンキングの方法 |
US9700486B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
JP6195191B2 (ja) * | 2013-08-08 | 2017-09-13 | 極東製薬工業株式会社 | 無タンパク質・無脂質培地馴化細胞株を用いた組換えタンパク質の製造方法 |
JP6190205B2 (ja) * | 2013-08-08 | 2017-08-30 | 極東製薬工業株式会社 | 無タンパク質・無脂質培地馴化細胞株、その製造方法及び培地 |
JP6760927B2 (ja) | 2014-09-18 | 2020-09-23 | ジェンザイム・コーポレーション | 超高密度細胞バンキング方法 |
WO2021198781A2 (en) | 2020-04-02 | 2021-10-07 | Takeda Pharmaceutical Company Limited | Adamts13 variant, compositions, and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978616A (en) * | 1985-02-28 | 1990-12-18 | Verax Corporation | Fluidized cell cultivation process |
EP0531562A1 (de) * | 1991-09-11 | 1993-03-17 | Doerr, Hans-Wilhelm, Prof. Dr. med. | Kultivierung von Säugetierzellen |
DE69535940D1 (de) * | 1994-11-10 | 2009-06-04 | Baxter Healthcare Sa | Verfahren zur Herstellung von biologischen Produkten in Protein-freiem Kultur |
AU703484B2 (en) * | 1995-02-23 | 1999-03-25 | Quest International Services B.V. | Peptides for tissue and cell culture media |
AUPN442295A0 (en) * | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
-
1997
- 1997-06-20 AT AT0107397A patent/AT407255B/de not_active IP Right Cessation
-
1998
- 1998-06-19 US US09/100,253 patent/US6100061A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6100061A (en) | 2000-08-08 |
AT407255B (de) | 2001-02-26 |
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Legal Events
Date | Code | Title | Description |
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MK07 | Expiry |
Effective date: 20170620 |