ATA107397A - Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons - Google Patents
Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklonsInfo
- Publication number
- ATA107397A ATA107397A AT107397A AT107397A ATA107397A AT A107397 A ATA107397 A AT A107397A AT 107397 A AT107397 A AT 107397A AT 107397 A AT107397 A AT 107397A AT A107397 A ATA107397 A AT A107397A
- Authority
- AT
- Austria
- Prior art keywords
- cell clone
- serum
- protein
- obtaining
- free medium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US09/100,253 US6100061A (en) | 1997-06-20 | 1998-06-19 | Recombinant cell clone having increased stability in serum- and protein-free medium and a method of recovering the stable cell clone and the production of recombinant proteins by using a stable cell clone |
| US09/324,612 US6475725B1 (en) | 1997-06-20 | 1999-06-02 | Recombinant cell clones having increased stability and methods of making and using the same |
| US10/170,661 US6936441B2 (en) | 1997-06-20 | 2002-06-12 | Recombinant cell clones having increased stability and methods of making and using the same |
| US11/123,362 US7094574B2 (en) | 1997-06-20 | 2005-05-06 | Recombinant cell clones having increased stability and methods of making and using the same |
| US11/482,504 US20070161079A1 (en) | 1997-06-20 | 2006-07-07 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/488,441 US20090258391A1 (en) | 1997-06-20 | 2009-06-19 | Recombinant cell clones having increased stability and methods of making and using same |
| US12/488,465 US8080414B2 (en) | 1997-06-20 | 2009-06-19 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/778,776 US8084251B2 (en) | 1997-06-20 | 2010-05-12 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/848,897 US8084252B2 (en) | 1997-06-20 | 2010-08-02 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/986,111 US8329465B2 (en) | 1997-06-20 | 2011-01-06 | Recombinant cell clones having increased stability and methods of making and using the same |
| US14/567,942 USRE46745E1 (en) | 1997-06-20 | 2014-12-11 | Recombinant cell clones having increased stability and methods of making and using the same |
| US15/203,558 USRE46860E1 (en) | 1997-06-20 | 2016-07-06 | Recombinant cell clones having increased stability and methods of making and using the same |
| US15/203,550 USRE46897E1 (en) | 1997-06-20 | 2016-07-06 | Recombinant cell clones having increased stability and methods of making and using the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA107397A true ATA107397A (de) | 2000-06-15 |
| AT407255B AT407255B (de) | 2001-02-26 |
Family
ID=3506017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US6100061A (de) |
| AT (1) | AT407255B (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| WO1998008934A1 (en) * | 1996-08-30 | 1998-03-05 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
| US6475725B1 (en) * | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| US6747003B1 (en) * | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| PL204285B1 (pl) * | 2000-02-11 | 2009-12-31 | Bayer Healthcare Llc | Koniugat polipeptydowy, polipeptyd, sekwencja nukleotydowa, wektor ekspresyjny, komórka gospodarz, sposób wytwarzania koniugatu polipeptydowego, środek farmaceutyczny i zastosowanie koniugatu polipeptydowego |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7812132B2 (en) * | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| US20040185534A1 (en) * | 2000-10-02 | 2004-09-23 | Knudsen Ida Molgaard | Industrial-scale serum-free production of recombinant proteins in mammalian cells |
| US20040185535A1 (en) * | 2003-03-21 | 2004-09-23 | Giles Wilson | Industrial-scale serum-free production of recombinant FVII in mammalian cells |
| AU9165201A (en) * | 2000-10-02 | 2002-04-15 | Novo Nordisk As | Factor vii glycoforms |
| US7445924B2 (en) * | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| HUP0402158A2 (hu) * | 2001-10-02 | 2005-01-28 | Novo Nordisk Health Care Ag | Rekombináns fehérjék előállítási eljárása eukarióta sejtekben |
| US6825027B2 (en) | 2001-12-10 | 2004-11-30 | Baxter Healthcare S.A. | Method of production of purified hepatitis a virus particles and vaccine preparation |
| US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| US6830917B2 (en) | 2001-12-10 | 2004-12-14 | Baxter Healthcare S.A. | Method of isolation and purification of trypsin from pronase protease and use thereof |
| BR0309576A (pt) * | 2002-04-30 | 2005-02-09 | Maxygen Holdings Ltd | Variante de polipeptìdeo do fator vii (fvii) ou fator viia (fviia), sequência de nucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, uso de uma variante, e, método para tratar um mamìfero que tenha uma doença ou um distúrbio em que a formação de coágulo é desejável |
| JP3916516B2 (ja) * | 2002-06-10 | 2007-05-16 | 独立行政法人科学技術振興機構 | 硬組織−軟組織界面再生用足場材料 |
| JP2005532057A (ja) * | 2002-07-09 | 2005-10-27 | バクスター・インターナショナル・インコーポレイテッド | 細胞を培養するための動物性タンパク質非含有培地 |
| UA85543C2 (ru) | 2002-09-05 | 2009-02-10 | Бавариан Нордик А/С | Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных |
| CA2502162C (en) * | 2002-09-30 | 2014-04-15 | Bayer Healthcare Llc | Fvii or fviia variants having increased clotting activity |
| CU23097A1 (es) * | 2002-10-23 | 2005-11-18 | Centro Inmunologia Molecular | Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método |
| AU2004221761B2 (en) * | 2003-03-20 | 2010-01-07 | Bayer Healthcare Llc | FVII or FVIIa variants |
| DE602004025576D1 (de) * | 2003-06-19 | 2010-04-01 | Bayer Healthcare Llc | Varianten der faktor-vii- oder -viia-gla-domäne |
| EP1711513B1 (de) | 2003-12-01 | 2014-07-02 | Novo Nordisk Health Care AG | Nanofiltration von faktor vii lösungen zur entfernung von viren |
| JP2007515172A (ja) * | 2003-12-23 | 2007-06-14 | シェーリング コーポレイション | 無血清培地懸濁培養において安定なa549細胞株を生成するための方法 |
| EP1745141B2 (de) * | 2004-05-04 | 2019-09-25 | Novo Nordisk Health Care AG | O-verknüpfte glykoformen von faktor vii und verfahren zu deren herstellung |
| CA2578046A1 (en) * | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
| KR20070101227A (ko) | 2004-09-07 | 2007-10-16 | 아케믹스 코포레이션 | 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도 |
| US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| US8530192B2 (en) * | 2005-02-11 | 2013-09-10 | Novo Nordisk Healthcare Ag | Production of a polypeptide in a serum-free cell culture liquid containing plant protein hydrolysate |
| US20070231895A1 (en) * | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
| CA2633306A1 (en) | 2006-01-04 | 2007-07-12 | Baxter International Inc. | Oligopeptide-free cell culture media |
| US8383388B2 (en) * | 2006-06-19 | 2013-02-26 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| AU2008245821B2 (en) | 2007-04-26 | 2013-07-04 | Bayer Healthcare Llc | Stabilization of liquid solutions of recombinant protein for frozen storage |
| US20090203766A1 (en) * | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
| AU2008345231B2 (en) | 2007-12-27 | 2014-09-11 | Takeda Pharmaceutical Company Limited | Cell culture processes |
| CA2716801A1 (en) * | 2008-03-12 | 2009-09-17 | Wyeth Llc | Methods for identifying cells suitable for large-scale production of recombinant proteins |
| US20100120093A1 (en) | 2008-11-12 | 2010-05-13 | Baxter International Inc. | Method of Producing Serum-Free Insulin-Free Factor VII |
| US8313926B2 (en) | 2009-07-31 | 2012-11-20 | Baxter International Inc. | Methods for expressing ADAMTS proteins in cell culture medium supplemented with zinc |
| BR112012006283B1 (pt) | 2009-09-21 | 2022-03-15 | Takeda Pharmaceutical Company Limited | Formulação de adamts13 estabilizada, método para fabricar uma formulação de adamts13 estabilizada, kit, e, usos de adamts13 |
| PL3626736T3 (pl) | 2010-07-08 | 2025-10-13 | Takeda Pharmaceutical Company Limited | Sposób wytwarzania rekombinowanego vwf o dużej masie cząsteczkowej w hodowli komórkowej |
| WO2012023085A1 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
| US8795658B2 (en) | 2010-09-17 | 2014-08-05 | Baxter International Inc. | Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| HUE035941T2 (en) | 2011-08-02 | 2018-05-28 | Baxalta GmbH | Systems and Methods for Recombinant Production Methods to Increase Protein Yield |
| AU2013202965B2 (en) | 2013-03-15 | 2016-07-21 | Takeda Pharmaceutical Company Limited | Improved method for producing factor h from a plasma precipitation fraction |
| EP4008768A1 (de) | 2013-03-15 | 2022-06-08 | Genzyme Corporation | Verfahren zur speicherung hochdichter zellen |
| US9700486B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| JP6195191B2 (ja) * | 2013-08-08 | 2017-09-13 | 極東製薬工業株式会社 | 無タンパク質・無脂質培地馴化細胞株を用いた組換えタンパク質の製造方法 |
| JP6190205B2 (ja) * | 2013-08-08 | 2017-08-30 | 極東製薬工業株式会社 | 無タンパク質・無脂質培地馴化細胞株、その製造方法及び培地 |
| MX383858B (es) | 2014-09-18 | 2025-03-14 | Genzyme Corp | Métodos de establecimiento de bancos de células de densidad ultra-alta. |
| EP4127158A2 (de) | 2020-04-02 | 2023-02-08 | Takeda Pharmaceutical Company Limited | Adamts13-variante, zusammensetzungen und verwendungen davon |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4978616A (en) * | 1985-02-28 | 1990-12-18 | Verax Corporation | Fluidized cell cultivation process |
| EP0531562A1 (de) * | 1991-09-11 | 1993-03-17 | Doerr, Hans-Wilhelm, Prof. Dr. med. | Kultivierung von Säugetierzellen |
| EP0791055B1 (de) * | 1994-11-10 | 2012-01-25 | Baxter Healthcare S.A. | Verfahren zur herstellung von biologischen produkten in protein-freier kultur |
| AU703484B2 (en) * | 1995-02-23 | 1999-03-25 | Quest International Services B.V. | Peptides for tissue and cell culture media |
| AUPN442295A0 (en) * | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
-
1997
- 1997-06-20 AT AT0107397A patent/AT407255B/de not_active IP Right Cessation
-
1998
- 1998-06-19 US US09/100,253 patent/US6100061A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6100061A (en) | 2000-08-08 |
| AT407255B (de) | 2001-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK07 | Expiry |
Effective date: 20170620 |