AT366033B - Verfahren zur herstellung von n-cyano-n'-methyl-n"-(2-((5-methylimidazol-4-yl -methyl)-thioaethyl) -guanidin - Google Patents

Verfahren zur herstellung von n-cyano-n'-methyl-n"-(2-((5-methylimidazol-4-yl -methyl)-thioaethyl) -guanidin

Info

Publication number
AT366033B
AT366033B AT0498379A AT498379A AT366033B AT 366033 B AT366033 B AT 366033B AT 0498379 A AT0498379 A AT 0498379A AT 498379 A AT498379 A AT 498379A AT 366033 B AT366033 B AT 366033B
Authority
AT
Austria
Prior art keywords
methyl
thioaethyl
methylimidazol
guanidine
cyano
Prior art date
Application number
AT0498379A
Other languages
German (de)
English (en)
Other versions
ATA498379A (de
Inventor
Zdravko Dr Ing Crnic
Gordana Dr Ing Karlovic
Gorjana Dipl Ing Radobolja
Slobodan Dr Ing Djokic
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of ATA498379A publication Critical patent/ATA498379A/de
Application granted granted Critical
Publication of AT366033B publication Critical patent/AT366033B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT0498379A 1978-07-19 1979-07-19 Verfahren zur herstellung von n-cyano-n'-methyl-n"-(2-((5-methylimidazol-4-yl -methyl)-thioaethyl) -guanidin AT366033B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU1725/78A YU40716B (en) 1978-07-19 1978-07-19 Process for obtaining n-cyano-n'-methyl-n'-û2-|5-metylimidazole4-yl)-methyl¨-thioethylù guanidine

Publications (2)

Publication Number Publication Date
ATA498379A ATA498379A (de) 1981-07-15
AT366033B true AT366033B (de) 1982-03-10

Family

ID=25555343

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0498379A AT366033B (de) 1978-07-19 1979-07-19 Verfahren zur herstellung von n-cyano-n'-methyl-n"-(2-((5-methylimidazol-4-yl -methyl)-thioaethyl) -guanidin

Country Status (7)

Country Link
AT (1) AT366033B (sv)
CH (1) CH643246A5 (sv)
DE (1) DE2928857C3 (sv)
GB (1) GB2025969B (sv)
IT (1) IT1121013B (sv)
SU (1) SU886744A3 (sv)
YU (1) YU40716B (sv)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT378186B (de) * 1981-06-26 1985-06-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von cimetidin
AT378185B (de) * 1981-06-26 1985-06-25 Richter Gedeon Vegyeszet Verfahren zur herstellung eines neuen cimetidin-monohydrats

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY100734A (en) * 1986-09-01 1991-01-31 Mitsui Petrochemical Ind Process for preparation of guanidine derivative.
JPH0629234B2 (ja) * 1986-12-26 1994-04-20 三井石油化学工業株式会社 α−アシロキシケトン誘導体
US5808090A (en) * 1996-02-22 1998-09-15 Endo Pharmaceuticals Inc. Process for preventing precipitation in cimetidine injection solutions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1397436A (en) 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1533380A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531221A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT378186B (de) * 1981-06-26 1985-06-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von cimetidin
AT378185B (de) * 1981-06-26 1985-06-25 Richter Gedeon Vegyeszet Verfahren zur herstellung eines neuen cimetidin-monohydrats

Also Published As

Publication number Publication date
YU40716B (en) 1986-04-30
GB2025969B (en) 1982-09-02
YU172578A (en) 1982-10-31
IT7968506A0 (it) 1979-07-19
ATA498379A (de) 1981-07-15
CH643246A5 (de) 1984-05-30
DE2928857A1 (de) 1980-02-07
IT1121013B (it) 1986-03-26
DE2928857B2 (de) 1981-07-23
SU886744A3 (ru) 1981-11-30
DE2928857C3 (de) 1988-02-11
GB2025969A (en) 1980-01-30

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee