AT363955B - Verfahren zur herstellung von n-cyano-n'-(2-((4 -methyl-5-imidazolyl)methylthio)aethyl)-n''-alkinylguanidinen - Google Patents

Verfahren zur herstellung von n-cyano-n'-(2-((4 -methyl-5-imidazolyl)methylthio)aethyl)-n''-alkinylguanidinen

Info

Publication number
AT363955B
AT363955B AT0404378A AT404378A AT363955B AT 363955 B AT363955 B AT 363955B AT 0404378 A AT0404378 A AT 0404378A AT 404378 A AT404378 A AT 404378A AT 363955 B AT363955 B AT 363955B
Authority
AT
Austria
Prior art keywords
alkinylguanidines
aethyl
methylthio
imidazolyl
cyano
Prior art date
Application number
AT0404378A
Other languages
English (en)
Other versions
ATA404378A (de
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to AT552480A priority Critical patent/AT375348B/de
Publication of ATA404378A publication Critical patent/ATA404378A/de
Application granted granted Critical
Publication of AT363955B publication Critical patent/AT363955B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0404378A 1977-06-03 1978-06-02 Verfahren zur herstellung von n-cyano-n'-(2-((4 -methyl-5-imidazolyl)methylthio)aethyl)-n''-alkinylguanidinen AT363955B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT552480A AT375348B (de) 1977-06-03 1980-11-10 Verfahren zur herstellung von imidazolylguanidinen und von deren salzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03

Publications (2)

Publication Number Publication Date
ATA404378A ATA404378A (de) 1981-02-15
AT363955B true AT363955B (de) 1981-09-10

Family

ID=25185323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0404378A AT363955B (de) 1977-06-03 1978-06-02 Verfahren zur herstellung von n-cyano-n'-(2-((4 -methyl-5-imidazolyl)methylthio)aethyl)-n''-alkinylguanidinen

Country Status (8)

Country Link
US (2) US4158013A (de)
JP (2) JPS595581B2 (de)
AT (1) AT363955B (de)
AU (1) AU516144B2 (de)
BE (1) BE867594A (de)
HU (1) HU182645B (de)
SU (1) SU900809A3 (de)
ZA (1) ZA783141B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123920A1 (de) * 1983-03-30 1984-11-07 Ferrer Internacional, S.A. N-Cyano-formamidin-Verbindungen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
JPS5533416A (en) * 1978-08-31 1980-03-08 Sogo Yatsukou Kk Production of hexamethyene bis-dicyandiamide
US4431802A (en) * 1979-12-10 1984-02-14 G. D. Searle & Co. N-Heterocyclyl-N-cyano-N-(heterocyclythioalkyl)-guanidines
US4239908A (en) * 1979-12-10 1980-12-16 G.D. Searle & Co. N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines
DE3014353A1 (de) * 1980-04-15 1982-01-21 Bayer Ag, 5090 Leverkusen Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
US4588719A (en) * 1984-04-27 1986-05-13 William H. Rorer, Inc. Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2697727A (en) * 1953-04-28 1954-12-21 American Cyanamid Co Method of preparing s-alkyl cyanopseudothioureas
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1399283A (en) * 1972-04-20 1975-07-02 Smith Kline French Lab Pharmaceutical compositions
US3897555A (en) * 1972-05-22 1975-07-29 Smithkline Corp Pharmaceutical compositions and method of inhibiting gastric acid secretion
BE804144A (en) 1972-09-05 1974-02-28 Smith Kline French Lab H-2-Receptor antihistamines esp gastric acid inhibitors - -N-cyano-N"-(heterocyclyl-alkyl-(thio oxa amino or methylene-alkyl)-guanidines
US4093621A (en) * 1974-09-02 1978-06-06 Smith Kline & French Laboratories Limited Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1553070A (en) * 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
GB1578219A (en) * 1975-12-01 1980-11-05 Smith Kline French Lab Isothioureas

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123920A1 (de) * 1983-03-30 1984-11-07 Ferrer Internacional, S.A. N-Cyano-formamidin-Verbindungen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
ATA404378A (de) 1981-02-15
JPS595581B2 (ja) 1984-02-06
BE867594A (fr) 1978-11-29
JPS55157562A (en) 1980-12-08
AU516144B2 (en) 1981-05-21
US4157347A (en) 1979-06-05
JPS5737589B2 (de) 1982-08-10
SU900809A3 (ru) 1982-01-23
ZA783141B (en) 1979-06-27
AU3681678A (en) 1979-12-06
HU182645B (en) 1984-02-28
US4158013A (en) 1979-06-12
JPS55157559A (en) 1980-12-08

Similar Documents

Publication Publication Date Title
AT366671B (de) Verfahren zur herstellung von neuen imidazolidinen
AT383807B (de) Verfahren zur herstellung von neuen 7beta-(fluoriertes methylthio)-acetamido-7alphamethoxy-3-(1-(2-hydroxyalkyl)-1h-tetrazol-5-yl)
AT363955B (de) Verfahren zur herstellung von n-cyano-n'-(2-((4 -methyl-5-imidazolyl)methylthio)aethyl)-n''-alkinylguanidinen
AT366699B (de) Verfahren zur herstellung von 3'', 4''-diacyltylosinderivaten
ATA368281A (de) Verfahren zur herstellung von triazolderivaten
AT381948B (de) Verfahren zur herstellung von neuen (thio)hydantoinen
AT367739B (de) Verfahren zur herstellung von 2',6'-dialkyl-n(alkoxymethyl)-2-chloracetaniliden
ATA924678A (de) Verfahren zur herstellung von imidazolinen
AT366033B (de) Verfahren zur herstellung von n-cyano-n'-methyl-n"-(2-((5-methylimidazol-4-yl -methyl)-thioaethyl) -guanidin
LU79725A1 (fr) Procede de preparation de n-cyano-n'-(2-((4-methyl-5-imidazolyl)methylthio)ethyl)-n"-alkynylguanidines"
ATA19580A (de) Verfahren zur herstellung von blutdrucksenkendem 6,7-dimethoxy-4-amino-2-(4-(2-furoly)-1piperazinyl) chinazolinhydrochlorid
AT368991B (de) Verfahren zur herstellung von n-cyano-n'-methyln''-(2-mercapto[thyl)-guanidin
AT363101B (de) Verfahren zur herstellung von 1-(2'-furanidyl)5-fluoruracil
AT366052B (de) Verfahren zur herstellung von 4'-nitrobenzyl-7
AT358010B (de) Verfahren zur herstellung von 2(n-(2-hydroxy- aethyl)-n-niederalkylaminomethyl)-benzhydrolen
ATA514879A (de) Verfahren zur herstellung von reiner cyanursaeure
AT375653B (de) Verfahren zur herstellung von 2-oxodihydrobenzo(d)(1,3)-oxazinen
AT357263B (de) Verfahren zur herstellung von 4"-sulfonyl- aminooleandomycinderivaten
AT373872B (de) Verfahren zur herstellung von 2,2-dialkyl-4-methyl-5,5-dialkyl-3-formyl-3-pyr olinen
AT379146B (de) Verfahren zur herstellung von n'-(mono- oder disubstituierten)-n-aryl-harnstoff-derivaten
DD131646A1 (de) Verfahren zur herstellung von n,n'-bis-(alpha-hydroxy-beta,beta,beta-trichloraethyl)-harnstoff
ATA247884A (de) Verfahren zur herstellung von n-(2-pyrimidinyl)piperazinylalkylazaspiroalkandionen
AT381309B (de) Verfahren zur herstellung von 5z-formen von 2,3,4 -trinor-1,5-inter-m-phenylen-prostacyclinderiva en
AT353771B (de) Verfahren zur herstellung von neuen 2-(2',2'- dihalogenvinyl)-oder(2',2',2'-trihalogenaethyl)- cyclobutanonen
AT374195B (de) Verfahren zur herstellung von 2-(2-thenoylthio) -propionylglycin

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee