JPS55157559A - Novel intermediate useful for production of antitumor compounds - Google Patents

Novel intermediate useful for production of antitumor compounds

Info

Publication number
JPS55157559A
JPS55157559A JP3482980A JP3482980A JPS55157559A JP S55157559 A JPS55157559 A JP S55157559A JP 3482980 A JP3482980 A JP 3482980A JP 3482980 A JP3482980 A JP 3482980A JP S55157559 A JPS55157559 A JP S55157559A
Authority
JP
Japan
Prior art keywords
production
novel intermediate
intermediate useful
antitumor compounds
antitumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3482980A
Other languages
English (en)
Other versions
JPS5737589B2 (ja
Inventor
Rei Kurenshiyou Ronnii
Mitsuchieru Raaku Jiyooji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of JPS55157559A publication Critical patent/JPS55157559A/ja
Publication of JPS5737589B2 publication Critical patent/JPS5737589B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP3482980A 1977-06-03 1980-03-21 Novel intermediate useful for production of antitumor compounds Granted JPS55157559A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03

Publications (2)

Publication Number Publication Date
JPS55157559A true JPS55157559A (en) 1980-12-08
JPS5737589B2 JPS5737589B2 (ja) 1982-08-10

Family

ID=25185323

Family Applications (2)

Application Number Title Priority Date Filing Date
JP55034830A Expired JPS595581B2 (ja) 1977-06-03 1980-03-21 潰瘍抑制化合物類の製造に有用な新規中間体
JP3482980A Granted JPS55157559A (en) 1977-06-03 1980-03-21 Novel intermediate useful for production of antitumor compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP55034830A Expired JPS595581B2 (ja) 1977-06-03 1980-03-21 潰瘍抑制化合物類の製造に有用な新規中間体

Country Status (8)

Country Link
US (2) US4158013A (ja)
JP (2) JPS595581B2 (ja)
AT (1) AT363955B (ja)
AU (1) AU516144B2 (ja)
BE (1) BE867594A (ja)
HU (1) HU182645B (ja)
SU (1) SU900809A3 (ja)
ZA (1) ZA783141B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
JPS5533416A (en) * 1978-08-31 1980-03-08 Sogo Yatsukou Kk Production of hexamethyene bis-dicyandiamide
US4431802A (en) * 1979-12-10 1984-02-14 G. D. Searle & Co. N-Heterocyclyl-N-cyano-N-(heterocyclythioalkyl)-guanidines
US4239908A (en) * 1979-12-10 1980-12-16 G.D. Searle & Co. N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines
DE3014353A1 (de) * 1980-04-15 1982-01-21 Bayer Ag, 5090 Leverkusen Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
ES8407016A1 (es) * 1983-03-30 1984-08-16 Ferrer Int Procedimiento de obtencion de nuevas n-ciano-formamidinas.
US4588719A (en) * 1984-04-27 1986-05-13 William H. Rorer, Inc. Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2697727A (en) * 1953-04-28 1954-12-21 American Cyanamid Co Method of preparing s-alkyl cyanopseudothioureas
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1399283A (en) * 1972-04-20 1975-07-02 Smith Kline French Lab Pharmaceutical compositions
US3897555A (en) * 1972-05-22 1975-07-29 Smithkline Corp Pharmaceutical compositions and method of inhibiting gastric acid secretion
BE804144A (en) 1972-09-05 1974-02-28 Smith Kline French Lab H-2-Receptor antihistamines esp gastric acid inhibitors - -N-cyano-N"-(heterocyclyl-alkyl-(thio oxa amino or methylene-alkyl)-guanidines
US4093621A (en) * 1974-09-02 1978-06-06 Smith Kline & French Laboratories Limited Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1553070A (en) * 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
GB1578219A (en) * 1975-12-01 1980-11-05 Smith Kline French Lab Isothioureas

Also Published As

Publication number Publication date
SU900809A3 (ru) 1982-01-23
JPS595581B2 (ja) 1984-02-06
HU182645B (en) 1984-02-28
ATA404378A (de) 1981-02-15
JPS5737589B2 (ja) 1982-08-10
US4158013A (en) 1979-06-12
JPS55157562A (en) 1980-12-08
AT363955B (de) 1981-09-10
AU3681678A (en) 1979-12-06
AU516144B2 (en) 1981-05-21
ZA783141B (en) 1979-06-27
BE867594A (fr) 1978-11-29
US4157347A (en) 1979-06-05

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