AT334362B - Verfahren zur herstellung neuer heterocyclischer verbindungen und ihrer salze - Google Patents

Verfahren zur herstellung neuer heterocyclischer verbindungen und ihrer salze

Info

Publication number
AT334362B
AT334362B AT392974A AT392974A AT334362B AT 334362 B AT334362 B AT 334362B AT 392974 A AT392974 A AT 392974A AT 392974 A AT392974 A AT 392974A AT 334362 B AT334362 B AT 334362B
Authority
AT
Austria
Prior art keywords
salts
heterocyclic compounds
producing new
new heterocyclic
producing
Prior art date
Application number
AT392974A
Other languages
English (en)
Other versions
ATA392974A (de
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Application granted granted Critical
Publication of AT334362B publication Critical patent/AT334362B/de
Publication of ATA392974A publication Critical patent/ATA392974A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
AT392974A 1973-05-17 1974-05-13 Verfahren zur herstellung neuer heterocyclischer verbindungen und ihrer salze AT334362B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2356873A GB1421792A (en) 1973-05-17 1973-05-17 Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them

Publications (2)

Publication Number Publication Date
AT334362B true AT334362B (de) 1976-01-10
ATA392974A ATA392974A (de) 1976-05-15

Family

ID=10197791

Family Applications (1)

Application Number Title Priority Date Filing Date
AT392974A AT334362B (de) 1973-05-17 1974-05-13 Verfahren zur herstellung neuer heterocyclischer verbindungen und ihrer salze

Country Status (29)

Country Link
US (3) US3953460A (de)
JP (1) JPS5040560A (de)
AR (1) AR213262A1 (de)
AT (1) AT334362B (de)
BE (1) BE814941A (de)
BG (1) BG25786A3 (de)
CA (1) CA1050551A (de)
CS (1) CS185654B2 (de)
DD (1) DD113896A5 (de)
DE (1) DE2423813A1 (de)
ES (1) ES426405A1 (de)
FI (1) FI151974A (de)
FR (1) FR2229417B1 (de)
GB (1) GB1421792A (de)
HU (1) HU172300B (de)
IE (1) IE39435B1 (de)
IL (1) IL44752A (de)
IN (1) IN141252B (de)
LU (1) LU70104A1 (de)
MW (1) MW1774A1 (de)
NL (1) NL7406660A (de)
NO (1) NO141407C (de)
PH (1) PH11040A (de)
PL (1) PL102353B1 (de)
RO (1) RO69780A (de)
SE (1) SE416049B (de)
SU (1) SU537625A3 (de)
ZA (1) ZA742650B (de)
ZM (1) ZM7374A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554153A (en) * 1975-05-15 1979-10-17 Smith Kline French Lab Process for making 2-amino-2-alkylthionitroethylenes
US4192879A (en) * 1975-05-21 1980-03-11 Smith Kline & French Laboratories Limited Imidazolyl alkylamino nitroethylene compounds
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
GB1565966A (en) 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
US4169855A (en) * 1976-08-04 1979-10-02 Allen & Hansbury, Limited N'-derivatives of n-(2-mercapto-ethyl)-2-nitro-1,1-ethenediamine
ZA782129B (en) 1977-04-20 1979-03-28 Ici Ltd Hertocyclic derivatives
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4153704A (en) * 1977-05-16 1979-05-08 Smith Kline & French Laboratories Limited Ethylene derivatives
IE46886B1 (en) * 1977-05-17 1983-10-19 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
GB1601459A (en) 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
US4233302A (en) 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
ATE1353T1 (de) 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4584384A (en) * 1978-05-30 1986-04-22 Smith Kline & French Laboratories Limited Nitro pyrroles
ZA792608B (en) * 1978-05-30 1980-06-25 Smith Kline French Lab Nitro compounds
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
US4221737A (en) 1978-09-26 1980-09-09 Bristol-Myers Company 1-(Alkynyl)amino-1-(mercaptoalkyl)amino ethylenes
US4200760A (en) * 1978-09-26 1980-04-29 Bristol-Myers Company Imidazolylalkylthioalkylamino-ethylene derivatives
US4289876A (en) * 1978-11-24 1981-09-15 Bristol-Myers Company Antisecretory agents
US4250316A (en) * 1978-11-24 1981-02-10 Bristol-Myers Company Pyridyl guanidine anti-ulcer agents
US4282363A (en) * 1978-11-24 1981-08-04 Bristol-Myers Company 1-Nitro-2-(2-alkynylamino)-2-[(2-pyridylmethylthio)-ethylamino]ethylene derivatives
US4200578A (en) 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4287346A (en) * 1979-02-16 1981-09-01 Eisai Co., Ltd. Cyanoguanidine derivatives
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
FI803127L (fi) * 1979-10-03 1981-04-04 Glaxo Group Ltd Heterocykliska foereningar
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
US4525477A (en) * 1981-12-02 1985-06-25 Smith Kline & French Laboratories Limited 2-Thiazolyl, isothiazolyl, oxazolyl and isoxazolyl alkylamino-3-nitro-heterocyclic compounds
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
DE3232462A1 (de) * 1982-09-01 1984-03-01 Bayer Ag, 5090 Leverkusen 2-nitro-1,1-ethendiamine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
GB8415254D0 (en) * 1984-06-15 1984-07-18 Glaxo Group Ltd Amine derivatives
DE3546858C2 (de) * 1984-06-15 1995-04-20 Glaxo Group Ltd Verfahren zur Herstellung von Ranitidin
JPH085859B2 (ja) * 1986-07-01 1996-01-24 日本バイエルアグロケム株式会社 新規アルキレンジアミン類
ES2053462T3 (es) * 1987-04-06 1994-08-01 Heumann Pharma Gmbh & Co Procedimiento para la produccion de derivados de nitroetano.
EP0957907A4 (de) * 1996-08-06 2001-08-16 Smithkline Beecham Corp Il-8-rezeptor-antagonisten
AU7331098A (en) * 1997-05-07 1998-11-27 Novo Nordisk A/S Substituted 3,3-diamino-2-propenenitriles, their preparation and use
US5955548A (en) * 1997-05-07 1999-09-21 Novo Nordisk A/S Substituted 3, 3-diamino-2-propenenitriles, their preparation and use
GB9715814D0 (en) 1997-07-25 1997-10-01 Black James Foundation Histamine H3 receptor ligands
GB2344588B (en) * 1997-07-25 2001-11-14 Black James Foundation 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
KR100302348B1 (ko) * 1999-04-24 2001-09-22 류덕희 니자티딘의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1078569A (en) * 1962-12-06 1967-08-09 Gen Aniline & Film Corp Improvements in or relating to cyanoethylene compounds
US3404159A (en) * 1966-12-19 1968-10-01 Gaf Corp Bis hetero methylene malononitriles
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
US3808336A (en) * 1970-06-25 1974-04-30 Smithkline Corp Pharmaceutical compositions and methods of inhibiting histamine activity with thiourea derivatives
US3734924A (en) * 1970-10-14 1973-05-22 Smith Kline French Lab Carboxamidines
US3905984A (en) * 1971-03-09 1975-09-16 Smith Kline French Lab Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines

Also Published As

Publication number Publication date
DD113896A5 (de) 1975-07-05
CS185654B2 (en) 1978-10-31
FR2229417A1 (de) 1974-12-13
US4317829A (en) 1982-03-02
AR213262A1 (es) 1979-01-15
LU70104A1 (de) 1974-10-09
IE39435B1 (en) 1978-10-11
IL44752A0 (en) 1974-07-31
DE2423813A1 (de) 1974-12-05
ATA392974A (de) 1976-05-15
GB1421792A (en) 1976-01-21
CA1050551A (en) 1979-03-13
SU537625A3 (ru) 1976-11-30
IL44752A (en) 1978-10-31
FR2229417B1 (de) 1978-07-21
NO141407B (no) 1979-11-26
PH11040A (en) 1977-10-25
SE416049B (sv) 1980-11-24
US3953460A (en) 1976-04-27
RO69780A (ro) 1980-08-15
NO741815L (no) 1974-11-19
HU172300B (hu) 1978-07-28
AU6910574A (en) 1975-11-20
PL102353B1 (pl) 1979-03-31
BG25786A3 (en) 1978-12-12
NL7406660A (de) 1974-11-19
IN141252B (de) 1977-02-05
ZA742650B (en) 1975-04-30
NO141407C (no) 1980-03-05
MW1774A1 (en) 1975-07-09
US4284640A (en) 1981-08-18
FI151974A (de) 1974-11-18
ZM7374A1 (en) 1974-12-20
BE814941A (fr) 1974-11-13
ES426405A1 (es) 1976-07-01
IE39435L (en) 1974-11-17
JPS5040560A (de) 1975-04-14

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
EIH Change in the person of patent owner
ELA Expired due to lapse of time