AT325218B - Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen - Google Patents

Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen

Info

Publication number
AT325218B
AT325218B AT494373A AT494373A AT325218B AT 325218 B AT325218 B AT 325218B AT 494373 A AT494373 A AT 494373A AT 494373 A AT494373 A AT 494373A AT 325218 B AT325218 B AT 325218B
Authority
AT
Austria
Prior art keywords
benzomorphanes
9beta
heteroarylmethyl
dialkyl
preparation
Prior art date
Application number
AT494373A
Other languages
German (de)
English (en)
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Priority to AT489574A priority Critical patent/AT330372B/de
Priority to AT429175A priority patent/AT330373B/de
Application granted granted Critical
Publication of AT325218B publication Critical patent/AT325218B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
AT494373A 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen AT325218B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT489574A AT330372B (de) 1972-06-19 1974-06-14 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7- benzomorphanen
AT429175A AT330373B (de) 1972-06-19 1975-06-05 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7- benzomorphanen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229695A DE2229695A1 (de) 1972-06-19 1972-06-19 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
AT325218B true AT325218B (de) 1975-10-10

Family

ID=5848060

Family Applications (6)

Application Number Title Priority Date Filing Date
AT494373A AT325218B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489874*7A AT329199B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489474*7A AT328627B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (thienylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489974*7A AT329200B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7-benzomorphanen
AT490074*7A AT328629B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (furylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen
AT489774*7A AT328628B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroarylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen

Family Applications After (5)

Application Number Title Priority Date Filing Date
AT489874*7A AT329199B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489474*7A AT328627B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (thienylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489974*7A AT329200B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7-benzomorphanen
AT490074*7A AT328629B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (furylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen
AT489774*7A AT328628B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroarylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen

Country Status (13)

Country Link
US (1) US3931194A (en:Method)
JP (1) JPS5711908B2 (en:Method)
AT (6) AT325218B (en:Method)
BE (1) BE801079A (en:Method)
CH (9) CH582698A5 (en:Method)
DE (1) DE2229695A1 (en:Method)
DK (1) DK136904C (en:Method)
ES (8) ES416037A1 (en:Method)
FR (1) FR2189056B1 (en:Method)
GB (1) GB1433817A (en:Method)
NL (1) NL7308483A (en:Method)
NO (1) NO137694C (en:Method)
SE (1) SE405121B (en:Method)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
JPS63177704A (ja) * 1987-01-16 1988-07-21 松山株式会社 農作業機連結装置
TW200911796A (en) 2007-07-26 2009-03-16 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
AR069545A1 (es) 2007-11-16 2010-02-03 Boehringer Ingelheim Pharma Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y
EP2229368A1 (en) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
ATE531696T1 (de) * 2008-02-12 2011-11-15 Boehringer Ingelheim Int Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
JP5730021B2 (ja) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
DK2300461T3 (da) 2008-05-01 2013-06-03 Vitae Pharmaceuticals Inc Cycliske inhibitorer af 11beta-hydroxysteroid-dehydrogenase 1
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2730499A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
WO2013025664A1 (en) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1281227A (fr) * 1958-09-22 1962-01-12 Smith Kline French Lab Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
BE582575A (en:Method) * 1958-09-22
CS166801B2 (en:Method) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
SE392895B (sv) * 1971-08-24 1977-04-25 Sumitomo Chemical Co Forfarande for framstellning av bensomorfanderivat och deras salter

Also Published As

Publication number Publication date
AT328629B (de) 1976-03-25
CH589648A5 (en:Method) 1977-07-15
NO137694C (no) 1978-04-05
DK136904B (da) 1977-12-12
ES431511A1 (es) 1976-11-01
ES431512A1 (es) 1976-11-01
DE2229695A1 (de) 1974-01-31
CH582698A5 (en:Method) 1976-12-15
GB1433817A (en) 1976-04-28
ES431513A1 (es) 1976-11-01
CH582697A5 (en:Method) 1976-12-15
JPS5711908B2 (en:Method) 1982-03-08
ATA489974A (de) 1975-07-15
JPS4961170A (en:Method) 1974-06-13
AU5704673A (en) 1974-12-19
DK136904C (da) 1978-06-26
ATA489874A (de) 1975-07-15
FR2189056A1 (en:Method) 1974-01-25
NO137694B (no) 1977-12-27
CH583227A5 (en:Method) 1976-12-31
CH583230A5 (en:Method) 1976-12-31
AT328627B (de) 1976-03-25
CH583229A5 (en:Method) 1976-12-31
SE405121B (sv) 1978-11-20
CH583231A5 (en:Method) 1976-12-31
ATA490074A (de) 1975-06-15
ATA489474A (de) 1975-06-15
FR2189056B1 (en:Method) 1976-10-22
AT329199B (de) 1976-04-26
ES416037A1 (es) 1976-02-16
ES431510A1 (es) 1976-11-01
ES431515A1 (es) 1976-11-01
AT329200B (de) 1976-04-26
CH583228A5 (en:Method) 1976-12-31
ATA489774A (de) 1975-06-15
BE801079A (fr) 1973-12-18
ES431516A1 (es) 1976-11-16
ES431514A1 (es) 1976-11-01
US3931194A (en) 1976-01-06
NL7308483A (en:Method) 1973-12-21
CH589649A5 (en:Method) 1977-07-15
AT328628B (de) 1976-03-25

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Legal Events

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ELJ Ceased due to non-payment of the annual fee