ES431511A1 - Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos. - Google Patents

Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.

Info

Publication number
ES431511A1
ES431511A1 ES431511A ES431511A ES431511A1 ES 431511 A1 ES431511 A1 ES 431511A1 ES 431511 A ES431511 A ES 431511A ES 431511 A ES431511 A ES 431511A ES 431511 A1 ES431511 A1 ES 431511A1
Authority
ES
Spain
Prior art keywords
methyl
salts
benzomorphans
dialkyl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES431511A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES431511A1 publication Critical patent/ES431511A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ES431511A 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos. Expired ES431511A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229695A DE2229695A1 (de) 1972-06-19 1972-06-19 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES431511A1 true ES431511A1 (es) 1976-11-01

Family

ID=5848060

Family Applications (8)

Application Number Title Priority Date Filing Date
ES416037A Expired ES416037A1 (es) 1972-06-19 1973-06-18 Procedimiento para la preparacion de 2-(heteroaril-metil)- 5,9b-dialcohil-6,7-benzomorfanos.
ES431510A Expired ES431510A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431513A Expired ES431513A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431512A Expired ES431512A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431515A Expired ES431515A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431514A Expired ES431514A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431511A Expired ES431511A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES0431516A Expired ES431516A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2-(heterdanilmetilo 5,9-beta-dialcohil-6,7- benzonortanos.

Family Applications Before (6)

Application Number Title Priority Date Filing Date
ES416037A Expired ES416037A1 (es) 1972-06-19 1973-06-18 Procedimiento para la preparacion de 2-(heteroaril-metil)- 5,9b-dialcohil-6,7-benzomorfanos.
ES431510A Expired ES431510A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431513A Expired ES431513A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431512A Expired ES431512A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431515A Expired ES431515A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431514A Expired ES431514A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES0431516A Expired ES431516A1 (es) 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2-(heterdanilmetilo 5,9-beta-dialcohil-6,7- benzonortanos.

Country Status (13)

Country Link
US (1) US3931194A (es)
JP (1) JPS5711908B2 (es)
AT (6) AT328628B (es)
BE (1) BE801079A (es)
CH (9) CH583228A5 (es)
DE (1) DE2229695A1 (es)
DK (1) DK136904C (es)
ES (8) ES416037A1 (es)
FR (1) FR2189056B1 (es)
GB (1) GB1433817A (es)
NL (1) NL7308483A (es)
NO (1) NO137694C (es)
SE (1) SE405121B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
JPS63177704A (ja) * 1987-01-16 1988-07-21 松山株式会社 農作業機連結装置
WO2009017671A1 (en) 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CL2008003407A1 (es) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5538239B2 (ja) * 2008-02-12 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用
CA2715290A1 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200946520A (en) 2008-05-01 2009-11-16 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2724214A1 (en) 2008-05-13 2009-11-19 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2730499A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
EP2744783A1 (en) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Indenopyridine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1281227A (fr) * 1958-09-22 1962-01-12 Smith Kline French Lab Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
BE582575A (es) * 1958-09-22
CS166802B2 (es) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
SE392895B (sv) * 1971-08-24 1977-04-25 Sumitomo Chemical Co Forfarande for framstellning av bensomorfanderivat och deras salter

Also Published As

Publication number Publication date
ATA490074A (de) 1975-06-15
DK136904C (da) 1978-06-26
AT328628B (de) 1976-03-25
FR2189056B1 (es) 1976-10-22
ES416037A1 (es) 1976-02-16
ES431513A1 (es) 1976-11-01
CH583229A5 (es) 1976-12-31
AT329200B (de) 1976-04-26
NL7308483A (es) 1973-12-21
ATA489774A (de) 1975-06-15
CH583230A5 (es) 1976-12-31
ATA489974A (de) 1975-07-15
US3931194A (en) 1976-01-06
ES431515A1 (es) 1976-11-01
FR2189056A1 (es) 1974-01-25
DE2229695A1 (de) 1974-01-31
BE801079A (fr) 1973-12-18
DK136904B (da) 1977-12-12
ES431512A1 (es) 1976-11-01
JPS5711908B2 (es) 1982-03-08
ES431516A1 (es) 1976-11-16
NO137694B (no) 1977-12-27
CH583228A5 (es) 1976-12-31
AT329199B (de) 1976-04-26
NO137694C (no) 1978-04-05
AT328629B (de) 1976-03-25
AU5704673A (en) 1974-12-19
CH582698A5 (es) 1976-12-15
CH583231A5 (es) 1976-12-31
ES431514A1 (es) 1976-11-01
ES431510A1 (es) 1976-11-01
CH582697A5 (es) 1976-12-15
CH589648A5 (es) 1977-07-15
AT328627B (de) 1976-03-25
CH589649A5 (es) 1977-07-15
ATA489874A (de) 1975-07-15
GB1433817A (en) 1976-04-28
AT325218B (de) 1975-10-10
SE405121B (sv) 1978-11-20
CH583227A5 (es) 1976-12-31
ATA489474A (de) 1975-06-15
JPS4961170A (es) 1974-06-13

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