DK136904C - Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf

Info

Publication number
DK136904C
DK136904C DK336173A DK336173A DK136904C DK 136904 C DK136904 C DK 136904C DK 336173 A DK336173 A DK 336173A DK 336173 A DK336173 A DK 336173A DK 136904 C DK136904 C DK 136904C
Authority
DK
Denmark
Prior art keywords
benzomorphanes
9beta
racemic
dialkyl
heteroaryl
Prior art date
Application number
DK336173A
Other languages
Danish (da)
English (en)
Other versions
DK136904B (da
Inventor
H Merz
A Langbein
K Stockhaus
H Wick
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of DK136904B publication Critical patent/DK136904B/da
Application granted granted Critical
Publication of DK136904C publication Critical patent/DK136904C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
DK336173A 1972-06-19 1973-06-18 Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf DK136904C (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229695A DE2229695A1 (de) 1972-06-19 1972-06-19 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
DK136904B DK136904B (da) 1977-12-12
DK136904C true DK136904C (da) 1978-06-26

Family

ID=5848060

Family Applications (1)

Application Number Title Priority Date Filing Date
DK336173A DK136904C (da) 1972-06-19 1973-06-18 Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf

Country Status (13)

Country Link
US (1) US3931194A (es)
JP (1) JPS5711908B2 (es)
AT (6) AT329199B (es)
BE (1) BE801079A (es)
CH (9) CH582697A5 (es)
DE (1) DE2229695A1 (es)
DK (1) DK136904C (es)
ES (8) ES416037A1 (es)
FR (1) FR2189056B1 (es)
GB (1) GB1433817A (es)
NL (1) NL7308483A (es)
NO (1) NO137694C (es)
SE (1) SE405121B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
JPS63177704A (ja) * 1987-01-16 1988-07-21 松山株式会社 農作業機連結装置
ATE554078T1 (de) 2007-07-26 2012-05-15 Vitae Pharmaceuticals Inc Synthese von 11-beta-hydroxysteroid-dehydrogenase-1-hemmern
CA2704628C (en) * 2007-11-16 2016-11-29 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US20110028445A1 (en) * 2008-02-12 2011-02-03 Boehringer Ingelheim International Gmbh Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
EP2254872A2 (en) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
AR071236A1 (es) 2008-05-01 2010-06-02 Vitae Pharmaceuticals Inc Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
BRPI0911764A2 (pt) 2008-05-01 2015-10-06 Boehringer Ingelheim Int inibidores cíclicos de 11beta-hidroxiesteroide desigrogenase 1
WO2009138386A2 (en) 2008-05-13 2009-11-19 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
CN102119160B (zh) 2008-07-25 2014-11-05 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1281227A (fr) * 1958-09-22 1962-01-12 Smith Kline French Lab Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
BE582575A (es) * 1958-09-22
CS166802B2 (es) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
SE392895B (sv) * 1971-08-24 1977-04-25 Sumitomo Chemical Co Forfarande for framstellning av bensomorfanderivat och deras salter

Also Published As

Publication number Publication date
US3931194A (en) 1976-01-06
NO137694C (no) 1978-04-05
ES431510A1 (es) 1976-11-01
CH589648A5 (es) 1977-07-15
ES431515A1 (es) 1976-11-01
CH582698A5 (es) 1976-12-15
FR2189056B1 (es) 1976-10-22
ATA489974A (de) 1975-07-15
CH583227A5 (es) 1976-12-31
AT329200B (de) 1976-04-26
NO137694B (no) 1977-12-27
AT329199B (de) 1976-04-26
DK136904B (da) 1977-12-12
ATA490074A (de) 1975-06-15
GB1433817A (en) 1976-04-28
CH583229A5 (es) 1976-12-31
SE405121B (sv) 1978-11-20
AT328628B (de) 1976-03-25
ES431511A1 (es) 1976-11-01
ES431512A1 (es) 1976-11-01
ES416037A1 (es) 1976-02-16
JPS4961170A (es) 1974-06-13
CH583230A5 (es) 1976-12-31
CH583231A5 (es) 1976-12-31
FR2189056A1 (es) 1974-01-25
NL7308483A (es) 1973-12-21
CH589649A5 (es) 1977-07-15
AT325218B (de) 1975-10-10
ATA489774A (de) 1975-06-15
CH582697A5 (es) 1976-12-15
CH583228A5 (es) 1976-12-31
ATA489474A (de) 1975-06-15
ES431516A1 (es) 1976-11-16
ATA489874A (de) 1975-07-15
AT328627B (de) 1976-03-25
JPS5711908B2 (es) 1982-03-08
AU5704673A (en) 1974-12-19
ES431513A1 (es) 1976-11-01
DE2229695A1 (de) 1974-01-31
AT328629B (de) 1976-03-25
ES431514A1 (es) 1976-11-01
BE801079A (fr) 1973-12-18

Similar Documents

Publication Publication Date Title
DK136904C (da) Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf
DK131029B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-alkylaminopropaner eller syreadditionssalte deraf.
DK129447B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-sek.-alkylaminopropaner eller syreadditionssalte heraf.
DK142750C (da) Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive dopaminderivater eller syreadditionssalte deraf
DK138602B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive penicilliner eller salte deraf.
DK136527B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive p-alkoxyfenoxypropanolaminer eller syreadditionssalte deraf.
DK140281B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-cycloalkylaminopropaner eller syreadditionssalte heraf.
DK137990C (da) Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 1-arylpropyl-(2)-piperazinderivater eller syreadditionssalte deraf
DK129127B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 2-(furylmethyl)-6,7-benzomorphaner eller deres syreadditionssalte.
DK124081B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive piperazinderivater eller syreadditionssalte deraf.
DK139575B (da) Analogifremgangsmåde til fremstilling af 2-aminomethylen-1-indanon-forbindelser eller syreadditionssalte deraf.
DK138491B (da) Analogifremgangsmåde til fremstilling af N-(1-cyclohexyl-3-pyrrolidinyl)-benzamider eller syreadditionssalte deraf.
DK125639B (da) Analogifremgangsmåde til fremstilling af racemisk eller optisk aktivt 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylaminopropan eller syreadditionssalte heraf.
DK139582B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive benzocycloheptaisoquinolin-forbindelser eller syreadditionssalte deraf.
DK133980C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive diphenylalkyllactamimidderivater eller syreadditionssalte deraf
DK129235B (da) Fremgangsmåde til fremstilling af racemiske eller optisk aktive quinolinderivater eller syreadditionssalte deraf.
DK133555C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive n-thienylmethyl-heterocycliske forbindelser eller syreadditionssalte deraf
DK130958B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-hydroxyalkylaminopropaner eller fysiologisk tålelige syreadditionssalte heraf.
DK136823B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive derivater af imidazo(2,1-b)thiazol eller syreadditionssalte deraf.
DK132628B (da) Analogifremgangsmade til fremstilling af 1-(2-delta2-imidazolinyl)-2,2-diarylcyclopropaner eller syreadditionssalte deraf
DK129992B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 3,5-disubstituerede fenylætanolaminforbindelser eller terapeutisk acceptable syreadditionssalte deraf.
DK133004C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive benzomorphanderivater eller salte deraf
DK131470B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive thiazolino-pyrimidin-5-on derivater eller syreadditionssalte deraf.
DK135942C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive 1-(m-acyloxyphenyl)-1-hydroxy-2-n-alkylaminoethanereller syreadditionssalte deraf
DK135941C (da) Analogifremgangsmaade til fremstilling af 1-cyclopropyl-1-phenyl-3-amino-1-propanoler eller syreaddittionssalte deraf