AT325218B - Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen - Google Patents

Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen

Info

Publication number
AT325218B
AT325218B AT494373A AT494373A AT325218B AT 325218 B AT325218 B AT 325218B AT 494373 A AT494373 A AT 494373A AT 494373 A AT494373 A AT 494373A AT 325218 B AT325218 B AT 325218B
Authority
AT
Austria
Prior art keywords
benzomorphanes
9beta
heteroarylmethyl
dialkyl
preparation
Prior art date
Application number
AT494373A
Other languages
English (en)
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Priority to AT489574A priority Critical patent/AT330372B/de
Priority to AT429175A priority patent/AT330373B/de
Application granted granted Critical
Publication of AT325218B publication Critical patent/AT325218B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
AT494373A 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen AT325218B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT489574A AT330372B (de) 1972-06-19 1974-06-14 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7- benzomorphanen
AT429175A AT330373B (de) 1972-06-19 1975-06-05 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7- benzomorphanen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229695A DE2229695A1 (de) 1972-06-19 1972-06-19 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
AT325218B true AT325218B (de) 1975-10-10

Family

ID=5848060

Family Applications (6)

Application Number Title Priority Date Filing Date
AT489774*7A AT328628B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroarylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen
AT494373A AT325218B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroarylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489474*7A AT328627B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (thienylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489874*7A AT329199B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT490074*7A AT328629B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (furylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen
AT489974*7A AT329200B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7-benzomorphanen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT489774*7A AT328628B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroarylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen

Family Applications After (4)

Application Number Title Priority Date Filing Date
AT489474*7A AT328627B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (thienylmethyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT489874*7A AT329199B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphanen
AT490074*7A AT328629B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (furylmethyl) -5,9beta-dialkyl-6,7-benzomorphanen
AT489974*7A AT329200B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen 2- (heteroaryl-methyl) -5,9beta-dialkyl -6,7-benzomorphanen

Country Status (13)

Country Link
US (1) US3931194A (de)
JP (1) JPS5711908B2 (de)
AT (6) AT328628B (de)
BE (1) BE801079A (de)
CH (9) CH583230A5 (de)
DE (1) DE2229695A1 (de)
DK (1) DK136904C (de)
ES (8) ES416037A1 (de)
FR (1) FR2189056B1 (de)
GB (1) GB1433817A (de)
NL (1) NL7308483A (de)
NO (1) NO137694C (de)
SE (1) SE405121B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
JPS63177704A (ja) * 1987-01-16 1988-07-21 松山株式会社 農作業機連結装置
CL2008002199A1 (es) 2007-07-26 2009-10-23 Vitae Pharmaceuticals Inc Compuestos derivados de 1,3-oxazin-2-ona; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad asociada con la actividad de la 11beta-hidroxiesteroide deshidrogenasa tipo 1 (11beta-hsd1) tales como dislipidemia, hiperlipidemia, hipertension, obesidad y enfermedad cardiovascular, entre otras.
CL2008003407A1 (es) * 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
EP2229368A1 (de) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclische harnstoffe als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2711757C (en) * 2008-02-12 2016-07-26 Boehringer Ingelheim International Gmbh Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2009102460A2 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291370B1 (de) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
CA2723039A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
PL2300461T3 (pl) 2008-05-01 2013-09-30 Vitae Pharmaceuticals Inc Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1
CA2724214A1 (en) 2008-05-13 2009-11-19 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2324017B1 (de) 2008-07-25 2014-12-31 Boehringer Ingelheim International GmbH 11-beta-HYDROXYSTEROID-DEHYDROGENASE-1-HEMMER
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
AR078887A1 (es) * 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
WO2013025664A1 (en) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (de) * 1958-09-22
FR1281227A (fr) * 1958-09-22 1962-01-12 Smith Kline French Lab Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
CS166803B2 (de) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
SE392895B (sv) * 1971-08-24 1977-04-25 Sumitomo Chemical Co Forfarande for framstellning av bensomorfanderivat och deras salter

Also Published As

Publication number Publication date
AU5704673A (en) 1974-12-19
NO137694B (no) 1977-12-27
ES431511A1 (es) 1976-11-01
ES431512A1 (es) 1976-11-01
AT328628B (de) 1976-03-25
CH583229A5 (de) 1976-12-31
ATA489974A (de) 1975-07-15
AT328627B (de) 1976-03-25
CH583228A5 (de) 1976-12-31
CH583230A5 (de) 1976-12-31
NO137694C (no) 1978-04-05
ES431510A1 (es) 1976-11-01
FR2189056A1 (de) 1974-01-25
NL7308483A (de) 1973-12-21
JPS4961170A (de) 1974-06-13
ATA490074A (de) 1975-06-15
DK136904C (da) 1978-06-26
ES431514A1 (es) 1976-11-01
CH583231A5 (de) 1976-12-31
FR2189056B1 (de) 1976-10-22
CH589649A5 (de) 1977-07-15
CH583227A5 (de) 1976-12-31
AT329200B (de) 1976-04-26
JPS5711908B2 (de) 1982-03-08
ATA489874A (de) 1975-07-15
AT328629B (de) 1976-03-25
SE405121B (sv) 1978-11-20
ATA489474A (de) 1975-06-15
BE801079A (fr) 1973-12-18
ES431516A1 (es) 1976-11-16
DK136904B (da) 1977-12-12
CH582697A5 (de) 1976-12-15
CH582698A5 (de) 1976-12-15
AT329199B (de) 1976-04-26
DE2229695A1 (de) 1974-01-31
ES431513A1 (es) 1976-11-01
ES416037A1 (es) 1976-02-16
ATA489774A (de) 1975-06-15
GB1433817A (en) 1976-04-28
ES431515A1 (es) 1976-11-01
CH589648A5 (de) 1977-07-15
US3931194A (en) 1976-01-06

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Legal Events

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ELJ Ceased due to non-payment of the annual fee