AT313481B - Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden - Google Patents

Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden

Info

Publication number
AT313481B
AT313481B AT206271A AT206271A AT313481B AT 313481 B AT313481 B AT 313481B AT 206271 A AT206271 A AT 206271A AT 206271 A AT206271 A AT 206271A AT 313481 B AT313481 B AT 313481B
Authority
AT
Austria
Prior art keywords
azapyrimidinnucleosiden
Prior art date
Application number
AT206271A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19702012888 priority Critical patent/DE2012888C3/de
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of AT313481B publication Critical patent/AT313481B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12Triazine radicals
AT206271A 1970-03-14 1971-03-10 Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden AT313481B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19702012888 DE2012888C3 (de) 1970-03-14 1970-03-14

Publications (1)

Publication Number Publication Date
AT313481B true AT313481B (de) 1974-02-25

Family

ID=5765475

Family Applications (1)

Application Number Title Priority Date Filing Date
AT206271A AT313481B (de) 1970-03-14 1971-03-10 Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden

Country Status (20)

Country Link
US (1) US3817980A (de)
JP (1) JPS5527077B1 (de)
AT (1) AT313481B (de)
BE (1) BE764179A (de)
CA (1) CA946379A (de)
CH (1) CH552606A (de)
CS (1) CS162741B2 (de)
DE (1) DE2012888C3 (de)
DK (1) DK152134C (de)
ES (1) ES388193A1 (de)
FI (1) FI56018C (de)
FR (1) FR2085707B1 (de)
GB (1) GB1351003A (de)
HU (1) HU164144B (de)
IL (1) IL36363A (de)
NL (1) NL180835C (de)
PL (1) PL81543B1 (de)
SE (1) SE405253B (de)
SU (1) SU374828A3 (de)
ZA (1) ZA7101084B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300765A2 (de) * 1987-07-21 1989-01-25 Ethyl Corporation Verfahren zur Herstellung von 2'-Deoxynukleosiden

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1531469A (en) * 1975-12-18 1978-11-08 Farmaceutici Italia Daunosamine nucleosides
US4171431A (en) * 1976-08-19 1979-10-16 The Upjohn Company Nucleosides and process
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
US4423212A (en) * 1980-12-18 1983-12-27 The Upjohn Company Nucleosides and process
US5099010A (en) * 1983-01-17 1992-03-24 Research Corporation Intermediates in the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
US4730512A (en) * 1984-10-23 1988-03-15 Toyota Jidosha Kabushiki Kaisha Engine crankshaft structure
JPS60193997A (en) * 1984-03-14 1985-10-02 Sumitomo Chem Co Ltd New cyanoimidazole ribonucleoside derivative and its preparation
US6982253B2 (en) * 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
CA2499036A1 (en) * 2002-09-24 2004-04-08 Koronis Pharmaceuticals, Incorporated 1,3,5-triazines for treatment of viral diseases
AU2013200662B2 (en) * 2003-03-17 2015-04-02 Celgene International Sarl Methods for isolating crystalline Form I of 5-azacytidine
US6943249B2 (en) * 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
AU2012209018B2 (en) * 2003-03-17 2015-04-02 Celgene International Sarl Methods for isolating crystalline Form I of 5-azacytidine
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
US20060128653A1 (en) * 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of decitabine
US20060128654A1 (en) * 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
CN101877964A (zh) * 2007-09-26 2010-11-03 西乃山医学院 氮杂胞苷类似物及其用途
EP2050757A1 (de) * 2007-10-10 2009-04-22 Cilag AG Verfahren zur Herstellung von 2' -deoxy-5-Azacytidin (Decitabin)
EP2048151A1 (de) * 2007-10-10 2009-04-15 Cilag AG Verfahren zur Herstellung von Nukleosiden durch direkte Glykosidation der Nukleosidbase
WO2009139888A1 (en) 2008-05-15 2009-11-19 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
WO2010014883A2 (en) 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
CN102171233A (zh) * 2008-08-06 2011-08-31 西科尔公司 制备氮杂胞苷中间体的方法
KR101660549B1 (ko) 2008-08-08 2016-09-27 시노팜 타이완 리미티드 5―아자시토신 뉴클레오시드 및 이의 유도체의 제조 방법
KR101755725B1 (ko) * 2009-03-23 2017-07-07 암비트 바이오사이언시즈 코포레이션 병용 요법을 이용한 치료 방법
US20100249394A1 (en) * 2009-03-26 2010-09-30 Albemarle Corporation Processes for producing decitabine
IT1399195B1 (it) 2010-03-30 2013-04-11 Chemi Spa Processo per la sintesi di azacitidina e decitabina
KR20140019820A (ko) 2011-03-31 2014-02-17 셀진 인터내셔널 에스에이알엘 5-아자시티딘의 합성
KR101809858B1 (ko) 2012-04-04 2017-12-15 할로자임, 아이엔씨 항-히알루로난 제제 및 종양-표적 탁산을 이용한 병용 치료
CN103884809B (zh) * 2013-08-28 2016-01-27 鲁南制药集团股份有限公司 一种地西他滨中间体的分析检测方法
JP6162349B1 (ja) * 2016-04-21 2017-07-12 大原薬品工業株式会社 5−アザシチジン類の糖部シリルエーテル誘導体
CN108239128B (zh) 2016-12-23 2019-03-29 江苏奥赛康药业股份有限公司 β-核苷类化合物的制备方法
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1244790B (de) * 1963-10-29 1967-07-20 Ceskoslovenska Akademie Ved Verfahren zur Herstellung des cancerostatisch wirksamen 5-Azacytidins
GB1050899A (de) * 1963-12-22
US3328388A (en) * 1964-09-02 1967-06-27 Merck & Co Inc Arabinofuranosyl pyrimidines and methods of preparing same
US3346561A (en) * 1965-10-24 1967-10-10 Merck & Co Inc Pyrimidine 3-deoxynucleosides
US3531464A (en) * 1966-10-21 1970-09-29 Us Health Education & Welfare Alternative synthesis of 2'-deoxy-5-(trifluoromethyl)-uridine and the alphaanomer thereof
CH527207A (de) * 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
CH507969A (de) * 1968-11-12 1971-05-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
CH532062A (de) * 1968-11-13 1972-12-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glykosyl-5-azacytosinen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300765A2 (de) * 1987-07-21 1989-01-25 Ethyl Corporation Verfahren zur Herstellung von 2'-Deoxynukleosiden
EP0300765A3 (de) * 1987-07-21 1990-01-10 Ethyl Corporation Verfahren zur Herstellung von 2'-Deoxynukleosiden

Also Published As

Publication number Publication date
DK152134C (da) 1988-08-01
DE2012888B2 (de) 1980-07-10
NL7103459A (de) 1971-09-16
FR2085707B1 (de) 1975-04-18
FI56018B (fi) 1979-07-31
SE405253B (sv) 1978-11-27
IL36363D0 (en) 1971-05-26
CH552606A (de) 1974-08-15
NL180835B (nl) 1986-12-01
CA946379A (en) 1974-04-30
GB1351003A (en) 1974-04-24
DE2012888C3 (de) 1981-04-02
JPS5527077B1 (de) 1980-07-17
NL180835C (en) 1987-05-04
IL36363A (en) 1974-05-16
BE764179A1 (de)
DE2012888A1 (de) 1971-09-30
BE764179A (fr) 1971-09-13
DK152134B (da) 1988-02-01
HU164144B (de) 1973-12-28
CS162741B2 (de) 1975-07-15
FR2085707A1 (de) 1971-12-31
US3817980A (en) 1974-06-18
SU374828A3 (de) 1973-03-20
PL81543B1 (de) 1975-08-30
CA946379A1 (de)
ES388193A1 (es) 1973-05-01
ZA7101084B (en) 1971-10-27
FI56018C (fi) 1979-11-12

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee