AT313481B - Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden - Google Patents

Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden

Info

Publication number
AT313481B
AT313481B AT206271A AT206271A AT313481B AT 313481 B AT313481 B AT 313481B AT 206271 A AT206271 A AT 206271A AT 206271 A AT206271 A AT 206271A AT 313481 B AT313481 B AT 313481B
Authority
AT
Austria
Prior art keywords
preparation
azapyrimidine
nucleosides
azapyrimidine nucleosides
Prior art date
Application number
AT206271A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of AT313481B publication Critical patent/AT313481B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT206271A 1970-03-14 1971-03-10 Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden AT313481B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2012888A DE2012888C3 (de) 1970-03-14 1970-03-14 Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden

Publications (1)

Publication Number Publication Date
AT313481B true AT313481B (de) 1974-02-25

Family

ID=5765475

Family Applications (1)

Application Number Title Priority Date Filing Date
AT206271A AT313481B (de) 1970-03-14 1971-03-10 Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden

Country Status (19)

Country Link
US (1) US3817980A (de)
JP (1) JPS5527077B1 (de)
AT (1) AT313481B (de)
BE (1) BE764179A (de)
CA (1) CA946379A (de)
CH (1) CH552606A (de)
CS (1) CS162741B2 (de)
DE (1) DE2012888C3 (de)
DK (1) DK152134C (de)
ES (1) ES388193A1 (de)
FI (1) FI56018C (de)
FR (1) FR2085707B1 (de)
GB (1) GB1351003A (de)
HU (1) HU164144B (de)
IL (1) IL36363A (de)
NL (1) NL180835C (de)
PL (1) PL81543B1 (de)
SE (1) SE405253B (de)
ZA (1) ZA711084B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300765A2 (de) * 1987-07-21 1989-01-25 Ethyl Corporation Verfahren zur Herstellung von 2'-Deoxynukleosiden

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1531469A (en) * 1975-12-18 1978-11-08 Farmaceutici Italia Daunosamine nucleosides
US4171431A (en) * 1976-08-19 1979-10-16 The Upjohn Company Nucleosides and process
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
GB1601020A (en) 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4423212A (en) * 1980-12-18 1983-12-27 The Upjohn Company Nucleosides and process
US5099010A (en) * 1983-01-17 1992-03-24 Research Corporation Intermediates in the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
JPS60193997A (ja) * 1984-03-14 1985-10-02 Sumitomo Chem Co Ltd 新規シアノイミダゾ−ルリボヌクレオシド誘導体およびその製造法
US4730512A (en) * 1984-10-23 1988-03-15 Toyota Jidosha Kabushiki Kaisha Engine crankshaft structure
US6982253B2 (en) * 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US7772197B2 (en) * 2002-09-24 2010-08-10 1,3,5-Triazines for Treatment of Viral Diseases 1,3,5-triazines for treatment of viral diseases
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
AU2013200662B2 (en) * 2003-03-17 2015-04-02 Celgene International Sarl Methods for isolating crystalline Form I of 5-azacytidine
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
AU2012209018B2 (en) * 2003-03-17 2015-04-02 Celgene International Sarl Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
US20060128653A1 (en) * 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of decitabine
US20060128654A1 (en) * 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
KR20100072230A (ko) * 2007-09-26 2010-06-30 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 아자시티딘 유사체 및 이의 용도
EP2048151A1 (de) * 2007-10-10 2009-04-15 Cilag AG Verfahren zur Herstellung von Nukleosiden durch direkte Glykosidation der Nukleosidbase
EP2050757A1 (de) * 2007-10-10 2009-04-22 Cilag AG Verfahren zur Herstellung von 2' -deoxy-5-Azacytidin (Decitabin)
AU2009246926B2 (en) 2008-05-15 2014-06-26 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
WO2010014883A2 (en) 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
WO2010017374A1 (en) * 2008-08-06 2010-02-11 Sicor Inc. Process for preparing azacytidine intermediate
AR073003A1 (es) 2008-08-08 2010-10-06 Scinopharm Taiwan Ltd Proceso para preparar 5-azacitosina nucleosidos y sus derivados
CA2755976C (en) 2009-03-23 2020-04-07 Ambit Biosciences Corporation Methods of treatment using combination therapy
US20100249394A1 (en) * 2009-03-26 2010-09-30 Albemarle Corporation Processes for producing decitabine
IT1399195B1 (it) 2010-03-30 2013-04-11 Chemi Spa Processo per la sintesi di azacitidina e decitabina
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine
PT2833905T (pt) 2012-04-04 2018-08-06 Halozyme Inc Terapia de combinação com hialuronidase e um taxano dirigido a tumor
CN103884809B (zh) * 2013-08-28 2016-01-27 鲁南制药集团股份有限公司 一种地西他滨中间体的分析检测方法
JP6162349B1 (ja) * 2016-04-21 2017-07-12 大原薬品工業株式会社 ５−アザシチジン類の糖部シリルエーテル誘導体
CN108226309B (zh) 2016-12-13 2020-06-16 江苏奥赛康药业有限公司 一种右丙亚胺的分析方法
CN108239128B (zh) * 2016-12-23 2019-03-29 江苏奥赛康药业股份有限公司 β-核苷类化合物的制备方法
CN110128485B (zh) * 2018-02-09 2022-06-07 鲁南制药集团股份有限公司 一种阿扎胞苷的制备方法
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1244790B (de) * 1963-10-29 1967-07-20 Ceskoslovenska Akademie Ved Verfahren zur Herstellung des cancerostatisch wirksamen 5-Azacytidins
GB1050899A (de) * 1963-12-22
US3328388A (en) * 1964-09-02 1967-06-27 Merck & Co Inc Arabinofuranosyl pyrimidines and methods of preparing same
US3346561A (en) * 1965-10-24 1967-10-10 Merck & Co Inc Pyrimidine 3-deoxynucleosides
US3531464A (en) * 1966-10-21 1970-09-29 Us Health Education & Welfare Alternative synthesis of 2'-deoxy-5-(trifluoromethyl)-uridine and the alphaanomer thereof
CH527207A (de) * 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
CH507969A (de) * 1968-11-12 1971-05-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
CH532062A (de) * 1968-11-13 1972-12-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glykosyl-5-azacytosinen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300765A2 (de) * 1987-07-21 1989-01-25 Ethyl Corporation Verfahren zur Herstellung von 2'-Deoxynukleosiden
EP0300765A3 (de) * 1987-07-21 1990-01-10 Ethyl Corporation Verfahren zur Herstellung von 2'-Deoxynukleosiden

Also Published As

Publication number Publication date
DE2012888B2 (de) 1980-07-10
CH552606A (de) 1974-08-15
FI56018B (fi) 1979-07-31
ES388193A1 (es) 1973-05-01
FR2085707B1 (de) 1975-04-18
BE764179A (fr) 1971-09-13
DK152134C (da) 1988-08-01
IL36363A (en) 1974-05-16
FR2085707A1 (de) 1971-12-31
DE2012888C3 (de) 1981-04-02
CA946379A (en) 1974-04-30
NL7103459A (de) 1971-09-16
NL180835C (nl) 1987-05-04
CS162741B2 (de) 1975-07-15
ZA711084B (en) 1971-10-27
IL36363A0 (en) 1971-05-26
PL81543B1 (de) 1975-08-30
US3817980A (en) 1974-06-18
NL180835B (nl) 1986-12-01
DE2012888A1 (de) 1971-09-30
GB1351003A (en) 1974-04-24
JPS5527077B1 (de) 1980-07-17
SE405253B (sv) 1978-11-27
SU374828A3 (de) 1973-03-20
HU164144B (de) 1973-12-28
FI56018C (fi) 1979-11-12
DK152134B (da) 1988-02-01

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Legal Events

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ELJ Ceased due to non-payment of the annual fee