FI56018C - Foerfarande foer framstaellning av 5-azapyrimidinnukleosider - Google Patents

Foerfarande foer framstaellning av 5-azapyrimidinnukleosider

Info

Publication number
FI56018C
FI56018C FI33371A FI33371A FI56018C FI 56018 C FI56018 C FI 56018C FI 33371 A FI33371 A FI 33371A FI 33371 A FI33371 A FI 33371A FI 56018 C FI56018 C FI 56018C
Authority
FI
Finland
Prior art keywords
azapyrimidininnucleosider
foerfarande foer
foer framstaellning
framstaellning
foerfarande
Prior art date
Application number
FI33371A
Other languages
English (en)
Other versions
FI56018B (fi
Inventor
Helmut Vorbrueggen
Ulrich Niedballa
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE2012888A priority Critical patent/DE2012888C3/de
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of FI56018B publication Critical patent/FI56018B/fi
Publication of FI56018C publication Critical patent/FI56018C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12Triazine radicals
FI33371A 1970-03-14 1971-02-08 Foerfarande foer framstaellning av 5-azapyrimidinnukleosider FI56018C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE2012888A DE2012888C3 (fi) 1970-03-14 1970-03-14

Publications (2)

Publication Number Publication Date
FI56018B FI56018B (fi) 1979-07-31
FI56018C true FI56018C (fi) 1979-11-12

Family

ID=5765475

Family Applications (1)

Application Number Title Priority Date Filing Date
FI33371A FI56018C (fi) 1970-03-14 1971-02-08 Foerfarande foer framstaellning av 5-azapyrimidinnukleosider

Country Status (20)

Country Link
US (1) US3817980A (fi)
JP (1) JPS5527077B1 (fi)
AT (1) AT313481B (fi)
BE (1) BE764179A (fi)
CA (1) CA946379A (fi)
CH (1) CH552606A (fi)
CS (1) CS162741B2 (fi)
DE (1) DE2012888C3 (fi)
DK (1) DK152134C (fi)
ES (1) ES388193A1 (fi)
FI (1) FI56018C (fi)
FR (1) FR2085707B1 (fi)
GB (1) GB1351003A (fi)
HU (1) HU164144B (fi)
IL (1) IL36363A (fi)
NL (1) NL180835C (fi)
PL (1) PL81543B1 (fi)
SE (1) SE405253B (fi)
SU (1) SU374828A3 (fi)
ZA (1) ZA7101084B (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1531469A (en) * 1975-12-18 1978-11-08 Farmaceutici Italia Daunosamine nucleosides
US4171431A (en) * 1976-08-19 1979-10-16 The Upjohn Company Nucleosides and process
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
US4423212A (en) * 1980-12-18 1983-12-27 The Upjohn Company Nucleosides and process
US5099010A (en) * 1983-01-17 1992-03-24 Research Corporation Intermediates in the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
US4730512A (en) * 1984-10-23 1988-03-15 Toyota Jidosha Kabushiki Kaisha Engine crankshaft structure
JPS60193997A (en) * 1984-03-14 1985-10-02 Sumitomo Chem Co Ltd New cyanoimidazole ribonucleoside derivative and its preparation
CA1301166C (en) * 1987-07-21 1992-05-19 John Nicholas Freskos Process for preparing 2-deoxynucleosides
US6982253B2 (en) * 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
CA2499036A1 (en) * 2002-09-24 2004-04-08 Koronis Pharmaceuticals, Incorporated 1,3,5-triazines for treatment of viral diseases
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
AU2013200662B2 (en) * 2003-03-17 2015-04-02 Celgene International Sarl Methods for isolating crystalline Form I of 5-azacytidine
AU2012209018B2 (en) * 2003-03-17 2015-04-02 Celgene International Sarl Methods for isolating crystalline Form I of 5-azacytidine
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
US20060128653A1 (en) * 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of decitabine
US20060128654A1 (en) * 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
NZ583923A (en) * 2007-09-26 2012-05-25 Sinai School Medicine Azacytidine analogues and uses thereof
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
RU2476207C2 (ru) 2008-05-15 2013-02-27 Селджин Корпорейшн Пероральные составы, содержащие аналоги цитидина, и способы их использования
WO2010014883A2 (en) * 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
KR20110026019A (ko) * 2008-08-06 2011-03-14 시코르, 인크. 아자시티딘 중간체의 제조 방법
ES2487525T3 (es) 2008-08-08 2014-08-21 Scinopharm Taiwan Ltd. Procedimiento para preparar nucleósidos de 5-azacitosina y sus derivados
KR101755725B1 (ko) * 2009-03-23 2017-07-07 암비트 바이오사이언시즈 코포레이션 병용 요법을 이용한 치료 방법
US20100249394A1 (en) * 2009-03-26 2010-09-30 Albemarle Corporation Processes for producing decitabine
IT1399195B1 (it) 2010-03-30 2013-04-11 Chemi Spa Processo per la sintesi di azacitidina e decitabina
JP6289361B2 (ja) 2011-03-31 2018-03-07 セルジーン インターナショナル サルル 5−アザシチジンの合成
AU2013243873B2 (en) 2012-04-04 2016-08-25 Halozyme, Inc. Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
CN103884809B (zh) * 2013-08-28 2016-01-27 鲁南制药集团股份有限公司 一种地西他滨中间体的分析检测方法
JP6162349B1 (ja) * 2016-04-21 2017-07-12 大原薬品工業株式会社 5−アザシチジン類の糖部シリルエーテル誘導体
CN108239128B (zh) * 2016-12-23 2019-03-29 江苏奥赛康药业股份有限公司 β-核苷类化合物的制备方法
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1244790B (de) * 1963-10-29 1967-07-20 Ceskoslovenska Akademie Ved Verfahren zur Herstellung des cancerostatisch wirksamen 5-Azacytidins
GB1050899A (fi) * 1963-12-22
US3328388A (en) * 1964-09-02 1967-06-27 Merck & Co Inc Arabinofuranosyl pyrimidines and methods of preparing same
US3346561A (en) * 1965-10-24 1967-10-10 Merck & Co Inc Pyrimidine 3-deoxynucleosides
US3531464A (en) * 1966-10-21 1970-09-29 Us Health Education & Welfare Alternative synthesis of 2'-deoxy-5-(trifluoromethyl)-uridine and the alphaanomer thereof
CH527207A (de) * 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
CH507969A (de) * 1968-11-12 1971-05-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
CH532062A (de) * 1968-11-13 1972-12-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glykosyl-5-azacytosinen

Also Published As

Publication number Publication date
DE2012888C3 (fi) 1981-04-02
NL7103459A (fi) 1971-09-16
DE2012888B2 (fi) 1980-07-10
US3817980A (en) 1974-06-18
DK152134B (da) 1988-02-01
NL180835B (nl) 1986-12-01
FR2085707A1 (fi) 1971-12-31
BE764179A1 (fi)
GB1351003A (en) 1974-04-24
NL180835C (en) 1987-05-04
CS162741B2 (fi) 1975-07-15
ES388193A1 (es) 1973-05-01
SE405253B (sv) 1978-11-27
AT313481B (de) 1974-02-25
BE764179A (fr) 1971-09-13
FR2085707B1 (fi) 1975-04-18
PL81543B1 (fi) 1975-08-30
HU164144B (fi) 1973-12-28
CA946379A1 (fi)
SU374828A3 (fi) 1973-03-20
IL36363D0 (en) 1971-05-26
FI56018B (fi) 1979-07-31
CH552606A (de) 1974-08-15
DK152134C (da) 1988-08-01
JPS5527077B1 (fi) 1980-07-17
ZA7101084B (en) 1971-10-27
IL36363A (en) 1974-05-16
CA946379A (en) 1974-04-30
DE2012888A1 (fi) 1971-09-30

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