AT296504B - Verfahren zur Herstellung des neuen 7-(D-α-Aminophenylacetamido)-3-methyl-3-cephem-4-carbonsäure-Monohydrats (Cephalexinmonohydrats) - Google Patents

Verfahren zur Herstellung des neuen 7-(D-α-Aminophenylacetamido)-3-methyl-3-cephem-4-carbonsäure-Monohydrats (Cephalexinmonohydrats)

Info

Publication number
AT296504B
AT296504B AT343670A AT343670A AT296504B AT 296504 B AT296504 B AT 296504B AT 343670 A AT343670 A AT 343670A AT 343670 A AT343670 A AT 343670A AT 296504 B AT296504 B AT 296504B
Authority
AT
Austria
Prior art keywords
monohydrate
aminophenylacetamido
cephem
methyl
preparation
Prior art date
Application number
AT343670A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of AT296504B publication Critical patent/AT296504B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Food-Manufacturing Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT343670A 1969-04-21 1970-04-15 Verfahren zur Herstellung des neuen 7-(D-α-Aminophenylacetamido)-3-methyl-3-cephem-4-carbonsäure-Monohydrats (Cephalexinmonohydrats) AT296504B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81812569A 1969-04-21 1969-04-21

Publications (1)

Publication Number Publication Date
AT296504B true AT296504B (de) 1972-02-25

Family

ID=25224730

Family Applications (1)

Application Number Title Priority Date Filing Date
AT343670A AT296504B (de) 1969-04-21 1970-04-15 Verfahren zur Herstellung des neuen 7-(D-α-Aminophenylacetamido)-3-methyl-3-cephem-4-carbonsäure-Monohydrats (Cephalexinmonohydrats)

Country Status (13)

Country Link
US (1) US3531481A (de)
JP (1) JPS505255B1 (de)
AT (1) AT296504B (de)
BR (1) BR6914945D0 (de)
CH (1) CH529790A (de)
CS (1) CS162720B2 (de)
DK (1) DK129458B (de)
ES (1) ES378832A1 (de)
GT (1) GT197016708A (de)
NO (1) NO135068C (de)
PL (1) PL80590B1 (de)
SE (1) SE361318B (de)
YU (1) YU39291B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317159A (en) * 1969-09-26 1973-05-16 Glaxo Lab Ltd Manufacture of cephalosporin compounds
US3687948A (en) * 1970-11-23 1972-08-29 Bristol Myers Co 7-{8 D-(a-AMINO-a-PHENYLACETAMIDO){9 -3-(4-METHYL-1,3-OXAZOL-2-YLTHIOMETHYL-3-CEPHEM-4-CARBOXYLIC ACID AND SALTS THEREOF
US3692781A (en) * 1971-02-26 1972-09-19 Glaxo Lab Ltd Recovery of pure cephalexin from acidic reaction mixtures
DE2317179C2 (de) * 1973-04-05 1982-11-25 Bristol-Myers Co., 10154 New York, N.Y. Verfahren zur Herstellung der relativ wasserunlöslichen kristallinen Form von Cefalexinmonohydrat
JPS5621395B2 (de) * 1973-07-18 1981-05-19
US4020060A (en) * 1975-07-22 1977-04-26 Richardson-Merrell Inc. 7-[α-Amino-ω-(3,4-methylenedioxyphenyl)acylamido]cephalosporanic acid derivatives
US4033956A (en) * 1975-07-22 1977-07-05 Richardson-Merrell Inc. 7[α-Amino-ω-(2,3-methylenedioxy-phenyl)acylamido]cephalosporanic acid derivatives
JPS5474966U (de) * 1977-11-07 1979-05-28
IT1126544B (it) * 1979-12-07 1986-05-21 Dobfar Spa Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
JPS6293589U (de) * 1985-11-29 1987-06-15
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate
US5412094A (en) * 1993-06-28 1995-05-02 Eli Lilly And Company Bicyclic beta-lactam/paraben complexes
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
AT406774B (de) * 1997-02-19 2000-08-25 Takeda Chemical Industries Ltd Cephalosporinkristalle und deren herstellung
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
CN113845529B (zh) * 2021-10-15 2024-02-27 东南大学 一种头孢氨苄共晶化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382241A (en) * 1967-02-27 1968-05-07 Lilly Co Eli Certain orally active cephalosporin antibiotics

Also Published As

Publication number Publication date
BR6914945D0 (pt) 1973-04-19
US3531481A (en) 1970-09-29
YU39291B (en) 1984-10-31
CS162720B2 (de) 1975-07-15
YU99470A (en) 1982-02-28
DK129458C (de) 1975-04-21
NO135068B (de) 1976-10-25
ES378832A1 (es) 1972-07-16
DK129458B (da) 1974-10-14
CH529790A (de) 1972-10-31
JPS505255B1 (de) 1975-03-01
NO135068C (de) 1977-02-02
SE361318B (de) 1973-10-29
PL80590B1 (en) 1975-08-30
GT197016708A (es) 1971-10-12

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee