AT249277B - Verfahren zur Herstellung neuer Benzomorphane - Google Patents

Verfahren zur Herstellung neuer Benzomorphane

Info

Publication number
AT249277B
AT249277B AT392965A AT392965A AT249277B AT 249277 B AT249277 B AT 249277B AT 392965 A AT392965 A AT 392965A AT 392965 A AT392965 A AT 392965A AT 249277 B AT249277 B AT 249277B
Authority
AT
Austria
Prior art keywords
benzomorphans
new
production
new benzomorphans
Prior art date
Application number
AT392965A
Other languages
German (de)
English (en)
Original Assignee
Geigy Ag J R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geigy Ag J R filed Critical Geigy Ag J R
Application granted granted Critical
Publication of AT249277B publication Critical patent/AT249277B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/26Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Discharge Lamp (AREA)
AT392965A 1963-12-20 1964-12-18 Verfahren zur Herstellung neuer Benzomorphane AT249277B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33229663A 1963-12-20 1963-12-20

Publications (1)

Publication Number Publication Date
AT249277B true AT249277B (de) 1966-09-12

Family

ID=23297612

Family Applications (4)

Application Number Title Priority Date Filing Date
AT392965A AT249277B (de) 1963-12-20 1964-12-18 Verfahren zur Herstellung neuer Benzomorphane
AT392865A AT249276B (de) 1963-12-20 1964-12-18 Verfahren zur Herstellung neuer Benzomorphane
AT1074264A AT261126B (de) 1963-12-20 1964-12-18 Verfahren zur Herstellung von neuen Benzomorphanen
AT1074364A AT253687B (de) 1963-12-20 1964-12-18 Verfahren zur Herstellung von neuen Benzomorphanen

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT392865A AT249276B (de) 1963-12-20 1964-12-18 Verfahren zur Herstellung neuer Benzomorphane
AT1074264A AT261126B (de) 1963-12-20 1964-12-18 Verfahren zur Herstellung von neuen Benzomorphanen
AT1074364A AT253687B (de) 1963-12-20 1964-12-18 Verfahren zur Herstellung von neuen Benzomorphanen

Country Status (12)

Country Link
AT (4) AT249277B (instruction)
BE (2) BE657406A (instruction)
CH (7) CH449641A (instruction)
DE (2) DE1445853A1 (instruction)
DK (4) DK108497C (instruction)
ES (4) ES307300A1 (instruction)
FR (2) FR4346M (instruction)
GB (2) GB1077711A (instruction)
IL (2) IL22642A (instruction)
NL (3) NL6414821A (instruction)
NO (2) NO119274B (instruction)
SE (2) SE322779B (instruction)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1506174B1 (en) 2002-05-17 2015-09-30 Taiwanj Pharmaceuticals Co., Ltd. Use of naltrexone for treating kidney and liver damage
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP5486928B2 (ja) 2007-02-26 2014-05-07 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1のサイクリックウレアおよびカルバメートインヒビター
CA2697168A1 (en) 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
TW200927115A (en) 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
EP2229368A1 (en) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5734666B2 (ja) 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1の1,3−オキサアゼパン−2−オン及び1,3−ジアゼパン−2−オン阻害剤
ATE531696T1 (de) * 2008-02-12 2011-11-15 Boehringer Ingelheim Int Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
EP2254872A2 (en) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター
CN102089300B (zh) 2008-05-01 2014-06-18 生命医药公司 11β-羟基类固醇脱氢酶1的环状抑制剂
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5451752B2 (ja) 2008-05-01 2014-03-26 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
EP2324017B1 (en) 2008-07-25 2014-12-31 Boehringer Ingelheim International GmbH INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
DK2324018T3 (da) 2008-07-25 2013-10-14 Boehringer Ingelheim Int Cykliske inhibitorer af 11 beta-hydroxysteroid dehydrogenase 1
AR073920A1 (es) 2008-10-23 2010-12-09 Boehringer Ingelheim Int Derivados urea de nortropanos sustituidos, medicamentos que contienen dichos compuestos , su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa y proceso para su preparacion.
US8637505B2 (en) 2009-02-04 2014-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010139673A1 (en) 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 1,3−オキサジナン−2−オン構造に基づく11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
UY33001A (es) 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
EP2635268A1 (en) 2010-11-02 2013-09-11 Boehringer Ingelheim International GmbH Pharmaceutical combinations for the treatment of metabolic disorders
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Also Published As

Publication number Publication date
ES307301A1 (es) 1965-05-16
DK108495C (da) 1967-12-27
NL6414820A (instruction) 1965-06-21
CH448118A (de) 1967-12-15
DK108496C (da) 1967-12-27
DE1445854A1 (de) 1968-12-05
IL22642A (en) 1968-07-25
SE305657B (instruction) 1968-11-04
NO119274B (instruction) 1970-04-27
GB1077711A (en) 1967-08-02
GB1092394A (en) 1967-11-22
AT261126B (de) 1968-04-10
CH449643A (de) 1968-01-15
IL22643A (en) 1968-07-25
BE657406A (instruction) 1965-06-21
AT253687B (de) 1967-04-25
AT249276B (de) 1966-09-12
CH449639A (de) 1968-01-15
CH449641A (de) 1968-01-15
NO119273B (instruction) 1970-04-27
CH449640A (de) 1968-01-15
DK108497C (da) 1967-12-27
CH446371A (de) 1967-11-15
ES307302A1 (es) 1965-05-16
ES307300A1 (es) 1965-05-01
SE322779B (instruction) 1970-04-20
NL127995C (instruction)
FR4346M (instruction) 1966-08-16
FR4345M (instruction) 1966-08-16
ES307299A1 (es) 1965-05-16
DK106552C (da) 1967-02-20
BE657405A (instruction) 1965-06-21
DE1445853A1 (de) 1968-12-05
NL6414821A (instruction) 1965-06-21
CH449642A (de) 1968-01-15

Similar Documents

Publication Publication Date Title
AT249277B (de) Verfahren zur Herstellung neuer Benzomorphane
CH443329A (de) Verfahren zur Herstellung von neuen Benzomorphane
CH474486A (de) Verfahren zur Herstellung neuer Diphenylharnstoffe
CH470345A (de) Verfahren zur Herstellung neuer Styryläthanolamine
CH519488A (de) Verfahren zur Herstellung neuer 19-Nor-androstatriene
AT248454B (de) Verfahren zur Herstellung neuer Organomolybdänverbindungen
CH441332A (de) Verfahren zur Herstellung neuer Benzolsulfonylsemicarbazide
AT252210B (de) Verfahren zur Herstellung von Phenolen
CH490350A (de) Verfahren zur Herstellung neuer antidiabetisch wirksamer Benzolsulfonyl-semicarbazide
CH443310A (de) Verfahren zur Herstellung neuer 2-Methyl-3-phenyl-3H-4-chinazolone
AT257934B (de) Verfahren zur Herstellung neuer Alkydharze
CH432538A (de) Verfahren zur Herstellung neuer Yohimban-Derivate
CH435261A (de) Verfahren zur Herstellung neuer 19-Nor-androstene
CH454138A (de) Verfahren zur Herstellung neuer Zinnkomplexsalze
CH468973A (de) Verfahren zur Herstellung neuer Acylamino-phenylarylketone
CH434520A (de) Verfahren zur Herstellung neuer Disazopigmente
CH473807A (de) Verfahren zur Herstellung neuer 4-Hydroxy-chinoline
CH442294A (de) Verfahren zur Herstellung neuer 7a-Methyl-androstene
AT252260B (de) Verfahren zur Herstellung neuer Kondensationsprodukte
AT248694B (de) Verfahren zur Herstellung neuer Telomerisate
CH475943A (de) Verfahren zur Herstellung neuer B-Alkoxy-trifluormethyl-phenäthyl-tert.-amine
CH439307A (de) Verfahren zur Herstellung neuer Phthalazinium-Verbindungen
CH455757A (de) Verfahren zur Herstellung neuer Phenyl-cyclohexylalkylamine
CH481083A (de) Verfahren zur Herstellung neuer 4-Halogen-androstene
CH443286A (de) Verfahren zur Herstellung neuer 7-a-Methyl-androstene